Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats
Advances in Biochemistry
Volume 7, Issue 2, June 2019, Pages: 51-58
Received: Jul. 27, 2019;
Accepted: Aug. 18, 2019;
Published: Aug. 26, 2019
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Afolabi Olusegun Kayode, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Arinola Abimbola, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Aderibigbe Felix Adesola, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Folarin Dasola Teslim, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Wusu Adedoja Dorcas, Department of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos
This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg-1), catechin only (CT) at 40mg kg-1, As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg-1 (1/20th LD50), As+DM-CT40 treated as As+DM in addition to oral administration of CT at 40mg kg-1 while the last group, As+DM-CT80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg-1. The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.
Afolabi Olusegun Kayode,
Aderibigbe Felix Adesola,
Folarin Dasola Teslim,
Wusu Adedoja Dorcas,
Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats, Advances in Biochemistry.
Vol. 7, No. 2,
2019, pp. 51-58.
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