Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar
Advances in Biochemistry
Volume 7, Issue 3, September 2019, Pages: 59-64
Received: Sep. 3, 2019;
Accepted: Sep. 27, 2019;
Published: Oct. 14, 2019
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Nènè Oumou Kesso Barry, Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal; Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Michel Assane Ndour, Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Moustapha Djite, Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal; Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Demba Diedhiou, Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Pape Matar Kandji, Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal; Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
El Hadji Malick Ndour, Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Gueye-tall Fatou, Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Aissatou Diallo, Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Ahmed Limane Barage, Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Maimouna Ndour Mbaye, Department of Internal Medicine, Abass Ndao Hospital Center, Dakar, Senegal
Philomène Lopez Sall, Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Papa Madieye Gueye, Laboratory of Pharmaceutical Biochemistry, University Cheikh Anta Diop, Dakar, Senegal; Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Low serum magnesium level has been shown to be associated with diabetes mellitus and its complications. The objective of this study was to determine the magnesium status in our study population and its association with glycemic control and microangiopathic complications particularly neuropathy and nephropathy. This was a cross sectional and prospective study conducted among patients received as part of their follow-up at the Marc Sankalé center of the Abass Ndao hospital in Dakar. For each patient, blood samples and 24h urine collection were performed. Hypomagnesemia was defined for Mg concentrations <17 mg/L and statistical analysis was performed using the XLSTAT 2018 software. A total of 106 diabetic patients were enrolled consisting of 93 type 2 diabetics and 13 type 1 diabetics. Eighty percent of patients had hypomagnesemia compared to 20% who had normal magnesium levels. We found a significantly higher mean HbA1c level in the group of hypomagnesemic patients compared to patients with normal magnesium levels (p = 0.02) and significant negative correlation between magnesium and HbA1c (r = - 0.20, p = 0.03). The frequencies of neuropathy and nephropathy were comparable between the two groups with respectively p = 0.12 and p = 0.28. Our study shows a high frequency of hypomagnesemia in both type 1 and type 2 diabetes and a significant correlation of this hypomagnesemia with poor glycemic control. No association has been found between magnesium and the microangiopathic complications, but it nevertheless alerts clinicians to the possible need for magnesium supplementation in the management of diabetic patients.
Nènè Oumou Kesso Barry,
Michel Assane Ndour,
Pape Matar Kandji,
El Hadji Malick Ndour,
Ahmed Limane Barage,
Maimouna Ndour Mbaye,
Philomène Lopez Sall,
Papa Madieye Gueye,
Association of Magnesium Status with Poor Glycemic Control and Microangiopathic Complications (Neuropathy and Nephropathy) in Diabetic Patients in Dakar, Advances in Biochemistry.
Vol. 7, No. 3,
2019, pp. 59-64.
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