The study investigated the effect of selenium-yeast on Blood glucose level in streptozotocin induced diabetic wistar rats. Diabetes mellitus was induced by single intraperitoneal (i.p) injection of streptozotocin dissolved in 0.1ml fresh cold citrate buffer pH 4.5 at a dose of 60 mg/kg body weight, after which the rats were randomly divided into seven groups. Group 1 Diabetic treated with 0.1 mg/kg of selenium-yeast. Group 2 Diabetic treated with 0.2 mg/kg of selenium-yeast respectively. Group 3 Diabetic treated with 1 mg/kg of Glibenclamide (GB). Group 4 served as normoglycemic control group and was administered normal saline (5ml/kg), Group 5 Diabetic untreated group received normal saline (5ml/kg), Group 6 Diabetic treated with 300mg/kg moderate dose of Aspirin. Group 7 Diabetic treated with 120 mg/kg of Ibuprofen. All treatments were given orally for two weeks. The results of the present study showed that blood plasma glucose level in the diabetic control group was significantly higher when compared with the normal control group in the entire 4-weeks of the study. Blood plasma glucose levels were significantly lower (p < 0.05) in the Group treated with 0.2 mg/kg selenium-yeast and the standard drug Glibenclamide at WK1 and WK3 when compared with the diabetic control Group. In conclusion. The above results suggest that Selenium-yeast has shown to possess hypoglycaemic property that is comparable to the oral-hypoglycaemic drug, glibenclamide.
| Published in | Cell Biology (Volume 3, Issue 1) |
| DOI | 10.11648/j.cb.20150301.12 |
| Page(s) | 14-18 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Selenium-Yeast, Streptozotocin, Glibenclamide, Aspirin, Ibuprofen
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APA Style
Mohammed Kabir Ahmed, Mohammed Aliyu, Tanko Yusuf, Musa Kabir Yusuf. (2015). Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats. Cell Biology, 3(1), 14-18. https://doi.org/10.11648/j.cb.20150301.12
ACS Style
Mohammed Kabir Ahmed; Mohammed Aliyu; Tanko Yusuf; Musa Kabir Yusuf. Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats. Cell Biol. 2015, 3(1), 14-18. doi: 10.11648/j.cb.20150301.12
AMA Style
Mohammed Kabir Ahmed, Mohammed Aliyu, Tanko Yusuf, Musa Kabir Yusuf. Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats. Cell Biol. 2015;3(1):14-18. doi: 10.11648/j.cb.20150301.12
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Download@article{10.11648/j.cb.20150301.12,
author = {Mohammed Kabir Ahmed and Mohammed Aliyu and Tanko Yusuf and Musa Kabir Yusuf},
title = {Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats},
journal = {Cell Biology},
volume = {3},
number = {1},
pages = {14-18},
doi = {10.11648/j.cb.20150301.12},
url = {https://doi.org/10.11648/j.cb.20150301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20150301.12},
abstract = {The study investigated the effect of selenium-yeast on Blood glucose level in streptozotocin induced diabetic wistar rats. Diabetes mellitus was induced by single intraperitoneal (i.p) injection of streptozotocin dissolved in 0.1ml fresh cold citrate buffer pH 4.5 at a dose of 60 mg/kg body weight, after which the rats were randomly divided into seven groups. Group 1 Diabetic treated with 0.1 mg/kg of selenium-yeast. Group 2 Diabetic treated with 0.2 mg/kg of selenium-yeast respectively. Group 3 Diabetic treated with 1 mg/kg of Glibenclamide (GB). Group 4 served as normoglycemic control group and was administered normal saline (5ml/kg), Group 5 Diabetic untreated group received normal saline (5ml/kg), Group 6 Diabetic treated with 300mg/kg moderate dose of Aspirin. Group 7 Diabetic treated with 120 mg/kg of Ibuprofen. All treatments were given orally for two weeks. The results of the present study showed that blood plasma glucose level in the diabetic control group was significantly higher when compared with the normal control group in the entire 4-weeks of the study. Blood plasma glucose levels were significantly lower (p < 0.05) in the Group treated with 0.2 mg/kg selenium-yeast and the standard drug Glibenclamide at WK1 and WK3 when compared with the diabetic control Group. In conclusion. The above results suggest that Selenium-yeast has shown to possess hypoglycaemic property that is comparable to the oral-hypoglycaemic drug, glibenclamide.},
year = {2015}
}
TY - JOUR T1 - Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats AU - Mohammed Kabir Ahmed AU - Mohammed Aliyu AU - Tanko Yusuf AU - Musa Kabir Yusuf Y1 - 2015/01/27 PY - 2015 N1 - https://doi.org/10.11648/j.cb.20150301.12 DO - 10.11648/j.cb.20150301.12 T2 - Cell Biology JF - Cell Biology JO - Cell Biology SP - 14 EP - 18 PB - Science Publishing Group SN - 2330-0183 UR - https://doi.org/10.11648/j.cb.20150301.12 AB - The study investigated the effect of selenium-yeast on Blood glucose level in streptozotocin induced diabetic wistar rats. Diabetes mellitus was induced by single intraperitoneal (i.p) injection of streptozotocin dissolved in 0.1ml fresh cold citrate buffer pH 4.5 at a dose of 60 mg/kg body weight, after which the rats were randomly divided into seven groups. Group 1 Diabetic treated with 0.1 mg/kg of selenium-yeast. Group 2 Diabetic treated with 0.2 mg/kg of selenium-yeast respectively. Group 3 Diabetic treated with 1 mg/kg of Glibenclamide (GB). Group 4 served as normoglycemic control group and was administered normal saline (5ml/kg), Group 5 Diabetic untreated group received normal saline (5ml/kg), Group 6 Diabetic treated with 300mg/kg moderate dose of Aspirin. Group 7 Diabetic treated with 120 mg/kg of Ibuprofen. All treatments were given orally for two weeks. The results of the present study showed that blood plasma glucose level in the diabetic control group was significantly higher when compared with the normal control group in the entire 4-weeks of the study. Blood plasma glucose levels were significantly lower (p < 0.05) in the Group treated with 0.2 mg/kg selenium-yeast and the standard drug Glibenclamide at WK1 and WK3 when compared with the diabetic control Group. In conclusion. The above results suggest that Selenium-yeast has shown to possess hypoglycaemic property that is comparable to the oral-hypoglycaemic drug, glibenclamide. VL - 3 IS - 1 ER -
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