Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats
Volume 3, Issue 1, January 2015, Pages: 14-18
Received: Jan. 9, 2015;
Accepted: Jan. 15, 2015;
Published: Jan. 27, 2015
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Mohammed Kabir Ahmed, Department of Human Physiology, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Mohammed Aliyu, Department of Human Physiology, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Tanko Yusuf, Department of Human Physiology, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Musa Kabir Yusuf, Department of Phamacognosy and Drug Design, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
The study investigated the effect of selenium-yeast on Blood glucose level in streptozotocin induced diabetic wistar rats. Diabetes mellitus was induced by single intraperitoneal (i.p) injection of streptozotocin dissolved in 0.1ml fresh cold citrate buffer pH 4.5 at a dose of 60 mg/kg body weight, after which the rats were randomly divided into seven groups. Group 1 Diabetic treated with 0.1 mg/kg of selenium-yeast. Group 2 Diabetic treated with 0.2 mg/kg of selenium-yeast respectively. Group 3 Diabetic treated with 1 mg/kg of Glibenclamide (GB). Group 4 served as normoglycemic control group and was administered normal saline (5ml/kg), Group 5 Diabetic untreated group received normal saline (5ml/kg), Group 6 Diabetic treated with 300mg/kg moderate dose of Aspirin. Group 7 Diabetic treated with 120 mg/kg of Ibuprofen. All treatments were given orally for two weeks. The results of the present study showed that blood plasma glucose level in the diabetic control group was significantly higher when compared with the normal control group in the entire 4-weeks of the study. Blood plasma glucose levels were significantly lower (p < 0.05) in the Group treated with 0.2 mg/kg selenium-yeast and the standard drug Glibenclamide at WK1 and WK3 when compared with the diabetic control Group. In conclusion. The above results suggest that Selenium-yeast has shown to possess hypoglycaemic property that is comparable to the oral-hypoglycaemic drug, glibenclamide.
Mohammed Kabir Ahmed,
Musa Kabir Yusuf,
Ameliorative Effect of Selenium Yeast on Blood Glucose Level in Streptozotocin Induced Diabetes in Wistar Rats, Cell Biology.
Vol. 3, No. 1,
2015, pp. 14-18.
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