Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits
Cell Biology
Volume 3, Issue 1, January 2015, Pages: 19-24
Received: Jan. 15, 2015; Accepted: Jan. 22, 2015; Published: Feb. 2, 2015
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Authors
Jimoh A., Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Tanko Y., Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Ahmed A., Department of Pharmacognosy, Ahmadu Bello University, Zaria, Nigeria
Mohammed A., Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria
Ayo J. O., Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria, Nigeria
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Abstract
Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P < 0.05) decrease in blood glucose level in HFD group treated with resveratrol compared with HFD group only after 5 weeks of the experimental protocol. Significant (P < 0.05) decrease in T3 and T4 levels were also observed in HFD group compared to the control group. Slight increase in T3 level was observed in HFD group treated with resveratrol but not significant (P > 0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.
Keywords
High Fat Diet, Blood Glucose Level, Rabbit, Thyroid Hormone
To cite this article
Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O., Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits, Cell Biology. Vol. 3, No. 1, 2015, pp. 19-24. doi: 10.11648/j.cb.20150301.13
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