Mitochondria are highly dynamic organelles that undergo cycles of fusion and fission important for their function, maintenance, and quality control as well as direct or indirect role in different types of stem cells fate decisions. Stem cells have potential for numerous biomedical applications; however the major bottle neck in stem cell field is the stem cell differentiation and maintenance of stemness of stem cells. The regulatory factor involved in stem cell fate decision and stem cell development is not clear. Recent report suggests that mitochondria also play a role in maintenance of pluripotency and cell fate decision. This review mainly cover the role of mitochondria, reactive oxygen species and change in mitochondria structure and functions during cell fate decision in different types of major group of stem cells. This article is a part of special issue on Mitochondria.
Mitochondria: A Key Player in Stem Cell Fate, Cell Biology. Special Issue:Mitochondria: Implications in Human Health and Diseases.
Vol. 3, No. 2-1,
2015, pp. 31-37.
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