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Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits

Received: 15 January 2015    Accepted: 22 January 2015    Published: 02 February 2015
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Abstract

Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P < 0.05) decrease in blood glucose level in HFD group treated with resveratrol compared with HFD group only after 5 weeks of the experimental protocol. Significant (P < 0.05) decrease in T3 and T4 levels were also observed in HFD group compared to the control group. Slight increase in T3 level was observed in HFD group treated with resveratrol but not significant (P > 0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.

DOI 10.11648/j.cb.20150301.13
Published in Cell Biology (Volume 3, Issue 1, January 2015)
Page(s) 19-24
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

High Fat Diet, Blood Glucose Level, Rabbit, Thyroid Hormone

References
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Author Information
  • Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria

  • Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria

  • Department of Pharmacognosy, Ahmadu Bello University, Zaria, Nigeria

  • Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria

  • Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria, Nigeria

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    Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. (2015). Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biology, 3(1), 19-24. https://doi.org/10.11648/j.cb.20150301.13

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    ACS Style

    Jimoh A.; Tanko Y.; Ahmed A.; Mohammed A.; Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015, 3(1), 19-24. doi: 10.11648/j.cb.20150301.13

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    AMA Style

    Jimoh A., Tanko Y., Ahmed A., Mohammed A., Ayo J. O. Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits. Cell Biol. 2015;3(1):19-24. doi: 10.11648/j.cb.20150301.13

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  • @article{10.11648/j.cb.20150301.13,
      author = {Jimoh A. and Tanko Y. and Ahmed A. and Mohammed A. and Ayo J. O.},
      title = {Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits},
      journal = {Cell Biology},
      volume = {3},
      number = {1},
      pages = {19-24},
      doi = {10.11648/j.cb.20150301.13},
      url = {https://doi.org/10.11648/j.cb.20150301.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.cb.20150301.13},
      abstract = {Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.},
     year = {2015}
    }
    

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    T1  - Protective Effect of Resveratrol Co-Administered with High Fat Diet on Blood Glucose Homeostasis and Thyroid Function in Rabbits
    AU  - Jimoh A.
    AU  - Tanko Y.
    AU  - Ahmed A.
    AU  - Mohammed A.
    AU  - Ayo J. O.
    Y1  - 2015/02/02
    PY  - 2015
    N1  - https://doi.org/10.11648/j.cb.20150301.13
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    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.cb.20150301.13
    AB  - Consumption of high fat diet rich in calorie has been associated with an increased incidence of diabetes mellitus. Deep underlying relation between diabetes mellitus and thyroid dysfunction has already been established. The aim of these experiments was to investigate the protective effect of resveratrol co-administration with high fat diet on blood glucose level and serum triiodothyronine (T3) and thyroxine (T4) levels in rabbits. Thirty rabbits divided into six group of five animal (n = 5) each were used for the experiment: Group 1 = normal control (C), group 2 = high fat diet (HFD) only, group 3 = resveratrol 200 mg/kg (R200), group 4 = resveratrol 400 mg/kg (R400), group 5 = HFD + R200 and group 6 = HFD + R400. Our finding demonstrate significant (P  0.05) compared to HFD group only. T4 level in the HFD group showed significant (P < 0.05) decrease compared to HFD group treated with resveratrol. In conclusion, the result demonstrated that co-administration of resveratrol with HFD decrease blood glucose level and improved T3 and T4 level in HFD fed rabbits.
    VL  - 3
    IS  - 1
    ER  - 

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