Mitochondria are highly dynamic organelles that undergo cycles of fusion and fission important for their function, maintenance, and quality control as well as direct or indirect role in different types of stem cells fate decisions. Stem cells have potential for numerous biomedical applications; however the major bottle neck in stem cell field is the stem cell differentiation and maintenance of stemness of stem cells. The regulatory factor involved in stem cell fate decision and stem cell development is not clear. Recent report suggests that mitochondria also play a role in maintenance of pluripotency and cell fate decision. This review mainly cover the role of mitochondria, reactive oxygen species and change in mitochondria structure and functions during cell fate decision in different types of major group of stem cells. This article is a part of special issue on Mitochondria.
Mitochondria: A Key Player in Stem Cell Fate, Cell Biology. Special Issue: Mitochondria: Implications in Human Health and Diseases.
Vol. 3, No. 2-1,
2015, pp. 31-37.
J. Jacobson and M.R. Duchen, “Interplay between mitochondria and cellular calcium signaling” Mol. Cell. Biochem. Vol. 256-257(1-2), pp. 209–218, 2004.
N.N. Danial and S.J. Korsmeyer “Cell death: critical control points”. Cell vol. 116, pp. 205–219, 2004.
S.D. Dyall, M.T. Brown and P.J. Johnson, “Ancient invasions: from endosymbionts to organelles”. Science vol. 304, pp. 253–257, 2004.
G. Attardi, “Animal mitochondrial DNA: An extreme example of genetic economy”. International Review of Cytology, vol. 93, pp. 93–145, 1985.
S. Anderson, A. T. Bankier, and B. G. Barrell, “Sequence and organization of the human mitochondrial genome”. Nature, vol. 290, pp. 457–465, 1981.
L.A. Sena, and N.S. Chandel, “Physiological roles of mitochondrial reactive oxygen species”. Mol. Cell, vol. 48, pp.158–167, 2012.
L. Thomas and B. Bavistar, “Mitochondria in stem cells”. Mitochondrion, vol. 7(5), pp. 289–296, 2007.
C.D. Folmes, P.P. Dzeja, T.J. Nelson, and A. Terzic, “Metabolic plasticity in stem cell homeostasis and differentiation”. Cell Stem Cell vol. 11, pp. 596–606, 2012.
V.A. Rafalski, E. Mancini, and A. Brunet, “Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate”. J. Cell Sci., vol. 125, pp. 5597–5608, 2012.
F. Hattori, H. Chen, H. Yamashita, S. Tohyama and Y.S. Satoh, “Nongenetic method for purifying stem cell-derived cardiomyocytes”. Nat Methods, vol. 7, pp. 61–66, 2010.
C.D. Folmes, T.J. Nelson, A. Martinez-Fernandez, D.K. Arrell, J.Z. Lindor, P.P. Dzeja, Y. Ikeda, C. Perez-Terzic, and A. Terzic, “Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming”. Cell Metab., vol. 14, pp. 264–271, 2011.
L. Lapasset, O. Milhavet, A. Prieur, E. Besnard, A. Babled, N. Aı¨t-Hamou, J. Leschik, F. Pellestor, , J.M. Ramirez, , J. De Vos, “Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state”. Genes Dev., vol. 25, pp. 2248–2253, 2011.
A. Prigione, B. Fauler, R. Lurz, H. Lehrach, J. Adjaye, “The senescencerelated mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells”. Stem Cells, vol. 28, pp. 721–733, 2010.
J. Zhang, I. Khvorostov, J.S. Hong, Y. Oktay, L. Vergnes, E. Nuebel, P.N. Wahjudi, K. Setoguchi, G. Wang and A. Do, “UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells”. EMBO J., vol. 30, pp. 4860–4873, 2011.
K. Wang, T. Zhang, Q. Dong, E. C. Nice and C.Huang, Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis., vol. 4(3), article e537, 2013.
G. C. Brown and V. Borutaite, “There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells,” Mitochondrion, vol. 12(1), pp. 1–4, 2012.
S. Pervaiz, R. Taneja, and S. Ghaffari, “Oxidative stress regulation of stem and progenitor cells,” Antioxidants and Redox Signaling, vol. 11(11), pp. 2777–2789, 2009.
L.B. Carolina, “Stem cells and the impact of ROS signaling”. Development, vol. 141, pp. 4206-4218, 2014.
A. Ludin, “Reactive Oxygen Species Regulate Hematopoietic Stem Cell Self-Renewal, Migration and Development, As Well As Their Bone Marrow Microenvironment”. ANTIOXIDANTS & REDOX SIGNALING Vol. 21(11), pp. 1605-1619, 2014.
J.R. Hom, R.A. Quintanilla, D.L. Hoffman, K.L. de Mesy Bentley, J.D. Molkentin, , S.S. Sheu, and G.A. Porter, “The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation”. Dev.Cell, 21, pp. 469–478, 2011.
T. Ishii and G. E. Mann, “Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity in the maintenance of redox balance,” Redox Biology, vol. 2, pp. 786–794, 2014.
A. Valle-Prieto and P. A. Conget, “Human mesenchymal stem cells efficiently manage oxidative stress,” Stem Cells and Development, vol.19, no. 12, pp. 1885–1893, 2010.
A.M. Singh, and S. Dalton, “The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming”. Cell Stem Cell, vol. 5, pp. 141–149, 2009.
Y. Wang, S. Baskerville, A. Shenoy, J.E. Babiarz, L. Baehner, and R. Blelloch, “Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation”. Nat. Genet., vol. 40, pp. 1478–1483, 2008.
M.J. Birket, A.L. Orr, A.A. Gerencser, D.T. Madden, C. Vitelli, A. Swistowski, M.D. Brand and X. Zeng, “A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells”. J. Cell Sci., vol. 124, pp. 348–358, 2011.
J.Shen, X.Liu , W.M.Yu , J.Liu, M.G. Nibbelink, C.Guo, T. Finkel and C.K. Qu, “A Critical Role of Mitochondrial Phosphatase Ptpmt1 in Embryogenesis Reveals a Mitochondrial Metabolic Stress-Induced Differentiation Checkpoint in Embryonic Stem Cells”. Mol. Cell. Biol., vol. 31(24), pp. 4902-4916, 2011.
A.D. Panopoulos, O. Yanes, S. Ruiz, Y.S. Kida, D. Diep, R. Tautenhahn, A. Herrerias, E.M. Batchelder, N. Plongthongkum, M. Lutz, W.T. Berggren, K. Zhang, R.M. Evans, G. Siuzdak and J.C. Belmonte, “The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming”. Cell Res., vol. 22, pp. 168-177, 2011.
J. Wang, P. Alexander, L.Wu, R. Hammer, O. Cleaver and S.L. McKnight, “Dependence of mouse embryonic stem cells on threonine catabolism”. Science vol. 325, pp. 435–439, 2009.
S. Mandal, A.G. Lindgren, A.S. Srivastava, A.T. Clark, and U. Banerjee, “Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells”. Stem Cells, vol. 29, pp. 486–495, 2011.
S. Yamanaka, “A fresh look at iPS cells”. Cell, vol. 137, pp. 13–17, 2009.
S. Nishikawa, R.A. Goldstein, C.R. Nierras, “The promise of human induced pluripotent stem cells for research and therapy”. Nat Rev Mol Cell Biol., vol. 9, pp. 725–729, 2008.
K. Takahashi, S. Yamanaka, “Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors.” Cell vol. 126(4), pp. 663-676, 2006.
D.C. Chan, “Mitochondria: dynamic organelles in disease, aging, and development”. Cell, vol. 125, pp. 1241–1252, 2006.
H. Chen, “Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations”. Cell, vol. 14,1pp. 280–289, 2010.
S. Varum, A.S. Rodrigues, M.B. Moura, O. Momcilovic, C.A. Easley, “Energy metabolism in human pluripotent stem cells and their differentiated counterparts”., vol. 6(6), pp. 1-16, 2011.
A. Vazquez-Martin, B. Corominas-Faja, S. Cufi, L. Vellon, C. Oliveras-Ferraros, O.J. Menendez, J. Joven, R. Lupu and J.A. Menendez, “The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells”. Cell Cycle, vol. 12, pp. 207–218, 2013.
C. Osman , D.R. Voelker and T. Langer, “Making heads or tails of phospholipids in mitochondria”. J. Cell Biol., vol. 192, pp. 7–16, 2011.
K.W. Orford and D.T. Scadden, “Deconstructing stem cell selfrenewal: genetic insights into cellcycle regulation”. Nat Rev Genet., vol. 9, pp. 115–128, 2008.
S.J. Morrison, D.T.Scadden, “The bone marrow niche for haematopoietic stem cells”. Nature, vol. 505, pp. 327–34, 2014.
J. Seita and L.W.Irving, “Hematopoietic Stem Cell: Self-renewal versus Differentiation.” Wiley Interdiscip Rev SystBiol Med., vol. 2(6), pp. 640–653, 2010.
X. Shi, Y. Zhang, J. Zheng and J. Pan, “Reactive oxygen species in cancer stem cells”. Antioxid Redox Signal, vol. 16(11), pp. 1215–1228, 2012.
J.E. Visvader and G.J. Lindeman, “Cancer stem cells in solid tumours: accumulating evidence and unresolved questions”. Nat Rev Cancer vol. 8(10), pp. 755–768, 2008.
C.E. Eyler and J.N. Rich, “Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol., vol. 26(17), pp. 2839–2845, 2008.
A.A. Dayem, H.Y. Choi, J.H. Kim and S.G. Cho, “Role of oxidative stress in stem, cancer, and cancer stem cells”. Cancers vol. 2(2), pp. 859–884, 2010.
M. Diehn, R.W. Cho and N.A. Lobo, “Association of reactive oxygen species levels and radio resistance in cancer stem cells”. Nature, vol. 458(7239), pp. 780–783, 2009.
T. Lonergan, B. Bavister and C. Brenner, “Mitochondria in stem cells”. Mitochondrion, vol. 7(5), pp. 289–296, 2007.
G. Kroemer and J. Pouyssegur, “Tumor cell metabolism: cancer’s Achilles’ heel”. Cancer Cell, vol. 13(6), pp. 472–482, 2008.
S.M. Schieke, M. Ma and L. Cao, “Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells”. J BiolChem., vol. 283, pp. 28506–12, 2008.
Z. Derdak, P. Fulop and E. Sabo, “Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress”. Carcinogenesis, vol. 27(5), pp. 956–961, 2006.
D. Trachootham, J. Alexandre and P. Huang, “Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach”. Nat Rev Drug Discov., vol. 8(7), pp. 579–591, 2009.
P. D. Ray, B.-W. Huang, and Y. Tsuji, “Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling,” Cellular Signalling, vol. 24(50), pp. 981–990, 2012.