International Journal of Immunology

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The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise

Received: 03 July 2017    Accepted: 18 July 2017    Published: 11 August 2017
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Abstract

This study was designed to determine the expression patterns of some pro-inflammatory and anti-inflammatory cytokine genes in some young male undergraduates that passed through exhaustive exercise using the Bruce protocol for sub-maximal acute exercise as studies have shown that exhaustive exercise activates the release of multiple cytokine genes which modulate the immune responses of stressed individuals. Twenty five (25) healthy young male undergraduates with an average age of 24.3±3 years and body mass index of 22.7±1.8 (Kg/m2) participated fully in the study. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Tumor necrosis factor α, interferon gamma and interleukin-10 genes expression patterns were detected using reverse transcriptase polymerase chain reaction methods. Serum cortisol (nmol/L) using enzyme-linked immunosorbent assay method. The study revealed that eleven (11) out of the twenty-five (25) participants had their tumor necrosis factor α genes up-regulated at 1 hour post exercise and sustained till 24 hours post exercise. Moreover, interferon gamma and interleukin-10 genes were up-regulated at 4 hours post exercise and sustained till 24 hours post exercise in most of the subjects. This study also observed that the cortisol level of the exercised subjects was significantly higher at 1 hour post acute exercise when compared with pre-exercise stage. Acute exercise was associated with an enhanced lymphocytic cell functions which are evidence in the up-regulation patterns of both lymphocytic pro-inflammatory cytokine and anti-inflammatory cytokine genes post exercise.

DOI 10.11648/j.iji.20170504.13
Published in International Journal of Immunology (Volume 5, Issue 4, August 2017)
Page(s) 74-79
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Tumor Necrosis Factor Alpha Genes, Exercise, Lymphocytic Cell Functions, Cytokines, Cortisol

References
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Author Information
  • Department of Hematology, College of Health Sciences, Igbinedion University, Okada, Nigeria; Lahor Research and Medical Centre, Benin City, Nigeria; Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Rehabilitation, Nnamdi Azikiwe University, Awka, Nigeria

  • Lahor Research and Medical Centre, Benin City, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

  • Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

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  • APA Style

    Ehiaghe Friday Alfred, Onyenekwe Charles Chinedum, Ifeanyichukwu Martins, Akosile Christopher Olusanjo, Ehiaghe Imuetiyan Joy, et al. (2017). The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise. International Journal of Immunology, 5(4), 74-79. https://doi.org/10.11648/j.iji.20170504.13

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    ACS Style

    Ehiaghe Friday Alfred; Onyenekwe Charles Chinedum; Ifeanyichukwu Martins; Akosile Christopher Olusanjo; Ehiaghe Imuetiyan Joy, et al. The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise. Int. J. Immunol. 2017, 5(4), 74-79. doi: 10.11648/j.iji.20170504.13

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    AMA Style

    Ehiaghe Friday Alfred, Onyenekwe Charles Chinedum, Ifeanyichukwu Martins, Akosile Christopher Olusanjo, Ehiaghe Imuetiyan Joy, et al. The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise. Int J Immunol. 2017;5(4):74-79. doi: 10.11648/j.iji.20170504.13

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  • @article{10.11648/j.iji.20170504.13,
      author = {Ehiaghe Friday Alfred and Onyenekwe Charles Chinedum and Ifeanyichukwu Martins and Akosile Christopher Olusanjo and Ehiaghe Imuetiyan Joy and Nancy Ibeh Chitogu and Ukibe Nkiruka Rose and Osakue Nosa and Ekpe Elijah Chukwuemeka},
      title = {The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise},
      journal = {International Journal of Immunology},
      volume = {5},
      number = {4},
      pages = {74-79},
      doi = {10.11648/j.iji.20170504.13},
      url = {https://doi.org/10.11648/j.iji.20170504.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.iji.20170504.13},
      abstract = {This study was designed to determine the expression patterns of some pro-inflammatory and anti-inflammatory cytokine genes in some young male undergraduates that passed through exhaustive exercise using the Bruce protocol for sub-maximal acute exercise as studies have shown that exhaustive exercise activates the release of multiple cytokine genes which modulate the immune responses of stressed individuals. Twenty five (25) healthy young male undergraduates with an average age of 24.3±3 years and body mass index of 22.7±1.8 (Kg/m2) participated fully in the study. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Tumor necrosis factor α, interferon gamma and interleukin-10 genes expression patterns were detected using reverse transcriptase polymerase chain reaction methods. Serum cortisol (nmol/L) using enzyme-linked immunosorbent assay method. The study revealed that eleven (11) out of the twenty-five (25) participants had their tumor necrosis factor α genes up-regulated at 1 hour post exercise and sustained till 24 hours post exercise. Moreover, interferon gamma and interleukin-10 genes were up-regulated at 4 hours post exercise and sustained till 24 hours post exercise in most of the subjects. This study also observed that the cortisol level of the exercised subjects was significantly higher at 1 hour post acute exercise when compared with pre-exercise stage. Acute exercise was associated with an enhanced lymphocytic cell functions which are evidence in the up-regulation patterns of both lymphocytic pro-inflammatory cytokine and anti-inflammatory cytokine genes post exercise.},
     year = {2017}
    }
    

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    T1  - The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise
    AU  - Ehiaghe Friday Alfred
    AU  - Onyenekwe Charles Chinedum
    AU  - Ifeanyichukwu Martins
    AU  - Akosile Christopher Olusanjo
    AU  - Ehiaghe Imuetiyan Joy
    AU  - Nancy Ibeh Chitogu
    AU  - Ukibe Nkiruka Rose
    AU  - Osakue Nosa
    AU  - Ekpe Elijah Chukwuemeka
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    DO  - 10.11648/j.iji.20170504.13
    T2  - International Journal of Immunology
    JF  - International Journal of Immunology
    JO  - International Journal of Immunology
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    EP  - 79
    PB  - Science Publishing Group
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    AB  - This study was designed to determine the expression patterns of some pro-inflammatory and anti-inflammatory cytokine genes in some young male undergraduates that passed through exhaustive exercise using the Bruce protocol for sub-maximal acute exercise as studies have shown that exhaustive exercise activates the release of multiple cytokine genes which modulate the immune responses of stressed individuals. Twenty five (25) healthy young male undergraduates with an average age of 24.3±3 years and body mass index of 22.7±1.8 (Kg/m2) participated fully in the study. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Tumor necrosis factor α, interferon gamma and interleukin-10 genes expression patterns were detected using reverse transcriptase polymerase chain reaction methods. Serum cortisol (nmol/L) using enzyme-linked immunosorbent assay method. The study revealed that eleven (11) out of the twenty-five (25) participants had their tumor necrosis factor α genes up-regulated at 1 hour post exercise and sustained till 24 hours post exercise. Moreover, interferon gamma and interleukin-10 genes were up-regulated at 4 hours post exercise and sustained till 24 hours post exercise in most of the subjects. This study also observed that the cortisol level of the exercised subjects was significantly higher at 1 hour post acute exercise when compared with pre-exercise stage. Acute exercise was associated with an enhanced lymphocytic cell functions which are evidence in the up-regulation patterns of both lymphocytic pro-inflammatory cytokine and anti-inflammatory cytokine genes post exercise.
    VL  - 5
    IS  - 4
    ER  - 

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