Linkage Disequilibrium and the Mapping of Human Disease Genes
International Journal of Genetics and Genomics
Volume 2, Issue 4, August 2014, Pages: 68-76
Received: Jun. 30, 2014; Accepted: Jul. 15, 2014; Published: Aug. 20, 2014
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Authors
Nahid Askari, Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman-Iran
Amin Baghizadeh, Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman-Iran
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Abstract
Identification of human disease genes can be accomplished by two strategies: functional cloning and positional cloning. Genetic mapping is the localization of genes underlying phenotypes on the basis of correlation with DNA variation, without the need for prior hypotheses about biological function and the simplest form, called linkage analysis. The ability to clone and sequence DNA made it possible to tie genetic linkage maps in model organisms to the underlying DNA sequence. In conclusion particular alleles at neighboring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles known as linkage disequilibrium (LD). Considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases.
Keywords
Human Disease Genes, Functional Cloning, Positional Cloning, Genetic Mapping, Mendelian Trait, Linkage Disequilibrium (LD)
To cite this article
Nahid Askari, Amin Baghizadeh, Linkage Disequilibrium and the Mapping of Human Disease Genes, International Journal of Genetics and Genomics. Vol. 2, No. 4, 2014, pp. 68-76. doi: 10.11648/j.ijgg.20140204.14
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