Trisomy 19 as the Sole Chromosomal Abnormality in CML
International Journal of Genetics and Genomics
Volume 2, Issue 4, August 2014, Pages: 77-79
Received: Aug. 4, 2014; Accepted: Aug. 19, 2014; Published: Aug. 30, 2014
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Salil N. Vaniawala, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza – A, Near RTO Circle, Surat, India
Pankaj K. Gadhia, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza – A, Near RTO Circle, Surat, India
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Presence of trisomy 19 in chronic myeloid leukemia (CML) normally considered as secondary abnormality but trisomy 19 rarely occur as sole abnormality. In the present study a total of 2312 Ph positive CML were screened from year2004 to 2014 and we found 2 cases of trisomy 19 as sole karyotype abnormalities. Both karyotype showed 47,XY,t(9;22)(q34;q11.2),+19,complements. It is not known that which gene(s) present on chromosome 19 plays important role in development of this condition.
Trisomy 19, Sole Chromosome Abnormality, CML
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Salil N. Vaniawala, Pankaj K. Gadhia, Trisomy 19 as the Sole Chromosomal Abnormality in CML, International Journal of Genetics and Genomics. Vol. 2, No. 4, 2014, pp. 77-79. doi: 10.11648/j.ijgg.20140204.15
R. La Sturza, N. Testoni, M. Lafage-Pochitaloff, D.Ruggeri, E. Ottaviani, G. Perla et al., “Complex variant Philadelphia translocation involving the Short arm of chromosome 6 in CML.” Hematologica, Vol. 87, pp. 143-47 2002.
T.G.Lugo, A.M. Pendergast, A. J. Muller, O.N. Witte, “Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, Vol. 247, pp. 1079-82, 1990.
I.L.Soon, H.S.Cho, C.H.Lee, K. D. Kim, J. K.Ha, M.K. Kim, K.H. Lee, M.S.Hyun, “Two cases of Trisomy19 as a sole chromosomal abnormality in myeloid disorders”. Kor. J. Lab. Med, Vol. 28, pp. 174 – 178, 2008.
B. Johansson, T. Fioretos, F. Mitelman, “cytogenetic and molecular genetic evolution of chronic myeloid leukemia” Acta Hematol, Vol. 107(2), pp.76-94, 2002.
J. L. Diez-Martin, G.W. Dewald, R. V. Pierre, “Possible cytogenetic distinction between lymphoid and myeloid blast crisis in chronic granulocytic leukemia” Am. J. Hematol, Vol. 27, pp. 194-203, 1988.
International System for Human Cytogenetics Nomenclature (ISCN), S. Karger Pub. Inc. 2009, 2013.
S. Luatti, F.castagnetti, G.Marzocchi, C. Bladdazi, G. Gugliotta, I. Lacobucci et al., “Additional chromosomal abnormalities in Philadelphia-positive clone: adverse prognostic influence on frontline imatinib therapy: a GIMEMA working party on CML analysis”, Blood, Vol. 120(4), pp. 716-67, 2012.
M. Daskalkis, N. Mauritzson, B. Johansson, K. Bouabdallah, F. Onida, R. Kunzamann, H. Muller-Berndroff, A. Schmidt-Graff, M. Lubbert, “Trisomy 19 as the sole chromosomal abnormality in proliferative chronic myelomonocytic leukemia”. Leukemia Res. Vol. 30, pp. 1043-47, 2006.
R.W. Yen, P.M. Vertino, B.D. Nelkin, J.J. Yu, W. El-Deiry, A. Cumarswamy, “Isolation and characterization of c-DNA encoding human DNA methyl-transferase”, Nucleic acid Res. Vol. 20(9), pp. 2289-91, 1992.
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