International Journal of Genetics and Genomics
Volume 2, Issue 4, August 2014, Pages: 77-79
Received: Aug. 4, 2014;
Accepted: Aug. 19, 2014;
Published: Aug. 30, 2014
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Salil N. Vaniawala, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza – A, Near RTO Circle, Surat, India
Pankaj K. Gadhia, Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, President Plaza – A, Near RTO Circle, Surat, India
Presence of trisomy 19 in chronic myeloid leukemia (CML) normally considered as secondary abnormality but trisomy 19 rarely occur as sole abnormality. In the present study a total of 2312 Ph positive CML were screened from year2004 to 2014 and we found 2 cases of trisomy 19 as sole karyotype abnormalities. Both karyotype showed 47,XY,t(9;22)(q34;q11.2),+19,complements. It is not known that which gene(s) present on chromosome 19 plays important role in development of this condition.
Salil N. Vaniawala,
Pankaj K. Gadhia,
Trisomy 19 as the Sole Chromosomal Abnormality in CML, International Journal of Genetics and Genomics.
Vol. 2, No. 4,
2014, pp. 77-79.
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