Esophageal cancer, including Squamous Cell Carcinoma and Adenocarcinoma, is one of the most common causes of cancer and cancer death globally, with China alone accounting for about half of the new cases worldwide in 2012. In this study we analyzed the presence of human papilloma virus (HPV) DNA and Tp53 mutations in 52 cancer patients, including 26 Squamous Cell Carcinoma cases, 21 Adenocarcinomas and 5 of non-described histology from Tangshan China. Overall 44 patients were positive for HPV L1 consensus, 28 were positive for HPV16 and 34 for HPV18 (84.62%, 53.82% and 65.38% respectively); 23 samples (44.23%) were positive for both HPV16 and HPV 18. We detected however a very low rate of Tp53 mutations in exons 5 through 8, which may possible be related to the elevated percentage of high risk HPV. Our findings corroborate our previous study on Esophageal Squamous Cell carcinoma in the same area but a further analysis on other Tp53 exons polymorphisms are necessary to understand the reason behind the low level of Tp53 mutations we reported.
| Published in | International Journal of Genetics and Genomics (Volume 4, Issue 2) |
| DOI | 10.11648/j.ijgg.20160402.12 |
| Page(s) | 11-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Esophageal Cancer, HPV, Tp53 Mutations
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APA Style
Vania H. M. Teofilo, Jintao Li, Mohammadreza Mohammadzad Mephryar, Si Ye, Shaomei Zhou, et al. (2016). High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China. International Journal of Genetics and Genomics, 4(2), 11-15. https://doi.org/10.11648/j.ijgg.20160402.12
ACS Style
Vania H. M. Teofilo; Jintao Li; Mohammadreza Mohammadzad Mephryar; Si Ye; Shaomei Zhou, et al. High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China. Int. J. Genet. Genomics 2016, 4(2), 11-15. doi: 10.11648/j.ijgg.20160402.12
AMA Style
Vania H. M. Teofilo, Jintao Li, Mohammadreza Mohammadzad Mephryar, Si Ye, Shaomei Zhou, et al. High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China. Int J Genet Genomics. 2016;4(2):11-15. doi: 10.11648/j.ijgg.20160402.12
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Download@article{10.11648/j.ijgg.20160402.12,
author = {Vania H. M. Teofilo and Jintao Li and Mohammadreza Mohammadzad Mephryar and Si Ye and Shaomei Zhou and Rugang Zhong and Yi Zeng},
title = {High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China},
journal = {International Journal of Genetics and Genomics},
volume = {4},
number = {2},
pages = {11-15},
doi = {10.11648/j.ijgg.20160402.12},
url = {https://doi.org/10.11648/j.ijgg.20160402.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20160402.12},
abstract = {Esophageal cancer, including Squamous Cell Carcinoma and Adenocarcinoma, is one of the most common causes of cancer and cancer death globally, with China alone accounting for about half of the new cases worldwide in 2012. In this study we analyzed the presence of human papilloma virus (HPV) DNA and Tp53 mutations in 52 cancer patients, including 26 Squamous Cell Carcinoma cases, 21 Adenocarcinomas and 5 of non-described histology from Tangshan China. Overall 44 patients were positive for HPV L1 consensus, 28 were positive for HPV16 and 34 for HPV18 (84.62%, 53.82% and 65.38% respectively); 23 samples (44.23%) were positive for both HPV16 and HPV 18. We detected however a very low rate of Tp53 mutations in exons 5 through 8, which may possible be related to the elevated percentage of high risk HPV. Our findings corroborate our previous study on Esophageal Squamous Cell carcinoma in the same area but a further analysis on other Tp53 exons polymorphisms are necessary to understand the reason behind the low level of Tp53 mutations we reported.},
year = {2016}
}
TY - JOUR T1 - High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China AU - Vania H. M. Teofilo AU - Jintao Li AU - Mohammadreza Mohammadzad Mephryar AU - Si Ye AU - Shaomei Zhou AU - Rugang Zhong AU - Yi Zeng Y1 - 2016/05/05 PY - 2016 N1 - https://doi.org/10.11648/j.ijgg.20160402.12 DO - 10.11648/j.ijgg.20160402.12 T2 - International Journal of Genetics and Genomics JF - International Journal of Genetics and Genomics JO - International Journal of Genetics and Genomics SP - 11 EP - 15 PB - Science Publishing Group SN - 2376-7359 UR - https://doi.org/10.11648/j.ijgg.20160402.12 AB - Esophageal cancer, including Squamous Cell Carcinoma and Adenocarcinoma, is one of the most common causes of cancer and cancer death globally, with China alone accounting for about half of the new cases worldwide in 2012. In this study we analyzed the presence of human papilloma virus (HPV) DNA and Tp53 mutations in 52 cancer patients, including 26 Squamous Cell Carcinoma cases, 21 Adenocarcinomas and 5 of non-described histology from Tangshan China. Overall 44 patients were positive for HPV L1 consensus, 28 were positive for HPV16 and 34 for HPV18 (84.62%, 53.82% and 65.38% respectively); 23 samples (44.23%) were positive for both HPV16 and HPV 18. We detected however a very low rate of Tp53 mutations in exons 5 through 8, which may possible be related to the elevated percentage of high risk HPV. Our findings corroborate our previous study on Esophageal Squamous Cell carcinoma in the same area but a further analysis on other Tp53 exons polymorphisms are necessary to understand the reason behind the low level of Tp53 mutations we reported. VL - 4 IS - 2 ER -
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