High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China
International Journal of Genetics and Genomics
Volume 4, Issue 2, April 2016, Pages: 11-15
Received: May 4, 2016;
Published: May 5, 2016
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Vania H. M. Teofilo, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China
Jintao Li, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China; State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Mohammadreza Mohammadzad Mephryar, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China
Si Ye, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China
Shaomei Zhou, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China
Rugang Zhong, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China
Yi Zeng, Beijing Key Lab. of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing Univ. of Technology, Beijing, China; State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Esophageal cancer, including Squamous Cell Carcinoma and Adenocarcinoma, is one of the most common causes of cancer and cancer death globally, with China alone accounting for about half of the new cases worldwide in 2012. In this study we analyzed the presence of human papilloma virus (HPV) DNA and Tp53 mutations in 52 cancer patients, including 26 Squamous Cell Carcinoma cases, 21 Adenocarcinomas and 5 of non-described histology from Tangshan China. Overall 44 patients were positive for HPV L1 consensus, 28 were positive for HPV16 and 34 for HPV18 (84.62%, 53.82% and 65.38% respectively); 23 samples (44.23%) were positive for both HPV16 and HPV 18. We detected however a very low rate of Tp53 mutations in exons 5 through 8, which may possible be related to the elevated percentage of high risk HPV. Our findings corroborate our previous study on Esophageal Squamous Cell carcinoma in the same area but a further analysis on other Tp53 exons polymorphisms are necessary to understand the reason behind the low level of Tp53 mutations we reported.
Vania H. M. Teofilo,
Mohammadreza Mohammadzad Mephryar,
High Prevalence of High Risk HPV with Low Frequency of Tp53 Mutations in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Patients in Tangshan China, International Journal of Genetics and Genomics.
Vol. 4, No. 2,
2016, pp. 11-15.
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