Fetal Stem Cells Use in Complex Treatment of Patients with Acquired Aplastic Anemia and Therapy Effect on Recovery of Hematopoietic Functions
International Journal of Genetics and Genomics
Volume 4, Issue 6, December 2016, Pages: 55-60
Received: Jan. 25, 2017; Accepted: Feb. 20, 2017; Published: Mar. 21, 2017
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Mikhail M. Shulak, Cell Therapy Center EmCell, Kyiv, Ukraine
Mariya O. Klunnyk, Cell Therapy Center EmCell, Kyiv, Ukraine
Iryna G. Matiyashchuk, Cell Therapy Center EmCell, Kyiv, Ukraine
Olena V. Ivankova, Cell Therapy Center EmCell, Kyiv, Ukraine
Marina V. Skalozub, Laboratory Department, Cell Therapy Center EmCell, Kyiv, Ukraine
Nataliia S. Sych, Cell Therapy Center EmCell, Kyiv, Ukraine
Mariya P. Demchuk, Cell Therapy Center EmCell, Kyiv, Ukraine
Andriy A. Sinelnyk, Cell Therapy Center EmCell, Kyiv, Ukraine
Timur V. Karayev, Cell Therapy Center EmCell, Kyiv, Ukraine
Khrystyna I. Sorochynska, Stem Cell Bank, Cell Therapy Center EmCell, Kyiv, Ukraine
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The principal objective was studying effects of complex treatment using fetal stem cells (FSCs) on recovery of hematopoietic function. 50 patients suffering from aplastic anemia of different disease severity were under study and underwent complex treatment by use of cryopreserved suspensions containing fetal liver cells extracted from 7-12 week gestation fetuses. During the above study we proved effectiveness of FSCs use for the patients with acquired aplastic anemia (AAA). Positive effects on patient’s subjective assessment of his/her condition along with an objective increase of tolerance to physical exercises were reported as early as during the first week after FSCs transplantation. We also recorded a stabilization of erythrocytes count, hemoglobin levels, platelets and leukocytes values in all patients under study. Reverse of infectious, hemorrhagic and anemic syndromes was achieved after treatment by use of FSCs. Significantly high erythrocytes and leucocytes counts controlled by laboratory tests together with reverse of anemia, hemorrhagic signs and infectious syndromes in the patients were also remarkable over 14 days after treatment. Within 7 days the patients felt improvement of their general state and increased tolerance to physical exercises. It has been proved that complex treatment by use of FSCs along with conventional therapy leads to stabilization of laboratory blood parameters and improved life quality among the patients with aplastic anemia.
Acquired Aplastic Anemia, Fetal Stem Cells, Recovery of Blood Hematopoietic Function, Myelodysplasia
To cite this article
Mikhail M. Shulak, Mariya O. Klunnyk, Iryna G. Matiyashchuk, Olena V. Ivankova, Marina V. Skalozub, Nataliia S. Sych, Mariya P. Demchuk, Andriy A. Sinelnyk, Timur V. Karayev, Khrystyna I. Sorochynska, Fetal Stem Cells Use in Complex Treatment of Patients with Acquired Aplastic Anemia and Therapy Effect on Recovery of Hematopoietic Functions, International Journal of Genetics and Genomics. Vol. 4, No. 6, 2016, pp. 55-60. doi: 10.11648/j.ijgg.20160406.13
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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