Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy
International Journal of Genetics and Genomics
Volume 4, Issue 6, December 2016, Pages: 61-67
Received: Mar. 1, 2016; Accepted: Mar. 22, 2016; Published: Mar. 22, 2017
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Abdolreza Esmaeilzadeh, Immunology Department and Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Elahe Reyhani, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
Nazila Bahmaie, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
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Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.
Dental Derived Stem Cells, Immunomodulation, Immune Markers, Cell Therapy, Tissue Reconstruction, Therapeutic Applications
To cite this article
Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie, Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy, International Journal of Genetics and Genomics. Vol. 4, No. 6, 2016, pp. 61-67. doi: 10.11648/j.ijgg.20160406.14
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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