Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy
International Journal of Genetics and Genomics
Volume 4, Issue 6, December 2016, Pages: 61-67
Received: Mar. 1, 2016; Accepted: Mar. 22, 2016; Published: Mar. 22, 2017
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Authors
Abdolreza Esmaeilzadeh, Immunology Department and Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Elahe Reyhani, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
Nazila Bahmaie, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
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Abstract
Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.
Keywords
Dental Derived Stem Cells, Immunomodulation, Immune Markers, Cell Therapy, Tissue Reconstruction, Therapeutic Applications
To cite this article
Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie, Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy, International Journal of Genetics and Genomics. Vol. 4, No. 6, 2016, pp. 61-67. doi: 10.11648/j.ijgg.20160406.14
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Karaöz E, Demircan PC, Sağlam Ö, Aksoy A, Kaymaz F, Duruksu G. Human dental pulp stem cells demonstrate better neural and epithelial stem cell properties than bone marrow-derived mesenchymal stem cells. Histochemistry and cell biology. 2011; 136(4): 455-73.
[2]
Mazaheri T, Esmaeilzadeh A, Mirzaei MHK. Introducing the immunomodulatory effects of mesenchymal stem cells in an experimental model of Behçet’s disease. Journal of Medical Hypotheses and Ideas. 2012; 6(1): 23-7.
[3]
Silva L. Stem Cells in the Oral Cavity.Glob J Stem Cell Biol Transplant .2015; 1(1): 012-016.
[4]
Estrela C, Alencar AHGd, Kitten GT, Vencio EF, Gava E. Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration. Brazilian dental journal. 2011; 22(2): 91-8.
[5]
Kawashima N. Characterisation of dental pulp stem cells: a new horizon for tissue regeneration? Archives of oral biology. 2012; 57(11): 1439-58.
[6]
KV KP, AI AK. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968; 6: 230.
[7]
Lindroos B, Mäenpää K, Ylikomi T, Oja H, Suuronen R, Miettinen S. Characterisation of human dental stem cells and buccal mucosa fibroblasts. Biochemical and biophysical research communications. 2008; 368(2): 329-35.
[8]
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue engineering. 2001; 7(2): 211-28.
[9]
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Advances in Tissue Engineering: Stem Cells New York: Mary Ann Liebert. 2010: 119-33.
[10]
Liu J, Yu F, Sun Y, Jiang B, Zhang W, Yang J, et al. Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue‐Derived Mesenchymal Stem Cells. Stem cells. 2015; 33(3): 627-38.
[11]
Feng R, Lengner C. Application of stem cell technology in dental regenerative medicine. Advances in wound care. 2013; 2(6): 296-305.
[12]
Manesh ME, Esmaeilzadeh A, Mirzaei MH. IL-24: A novel gene therapy candidate for immune system upregulation in Hodgkin’s lymphoma. Journal of Medical Hypotheses and Ideas. 2015; 9(1): 61-6.
[13]
Piri Z, Esmaeilzadeh A, Hajikhanmirzaei M. Interleukin-25 as a candidate gene in immunogene therapy of pancreatic cancer. Journal of Medical Hypotheses and Ideas. 2012; 6(2): 75-9.
[14]
Esmaeilzadeh A, Farshbaf A. Novel Approaches Based on Autologous Stem Cell Engineering and Gene-Modification; Evidence for the Cure of HIV/AIDS. J Genet Syndr Gene Ther. 2015; 6: 2.
[15]
Esmaeilzadeh A, Farshbaf A, Erfanmanesh M. Autologous Hematopoietic Stem Cells transplantation and genetic modification of CCR5 m303/m303 mutant patient for HIV/AIDS. Medical hypotheses. 2015; 84(3): 216-8.
[16]
Mirzaei MH, Esmaeilzadeh A. Overexpression of MDA-7/IL-24 as an anticancer cytokine in gene therapy of thyroid carcinoma. Journal of Medical Hypotheses and Ideas. 2014; 8(1): 7-13.
[17]
Esmaeilzadeh A, Farshbaf A. Mesenchymal Stem Cell as a Vector for Gene and Cell therapy Strategies. Glob J Stem Cell Biol Transplant. 2015; 1(1): 017-018.
[18]
Alleman M, Low E, Truong K, Huang E, Hill C, Chen T, et al. Dental pulp-derived stem cells (DPSC) differentiation in vitro into odontoblast and neuronal progenitors during cell passaging is associated with alterations in cell survival and viability. International Journal of Medicine and Biomedical Research. 2013; 2(2): 133-41.
[19]
Rosa V. What and where are the stem cells for Dentistry? Singapore dental journal. 2013; 34(1): 13-8.
[20]
Young A. Induction of Differentiation of Dental Pulp-Derived Mesenchymal Stem cells (DPSC). 2014 (Theses).
[21]
Pisciotta A, Carnevale G, Meloni S, Riccio M, De Biasi S, Gibellini L, et al. Human dental pulp stem cells (hDPSCs): isolation, enrichment and comparative differentiation of two sub-populations. BMC developmental biology. 2015; 15(1): 1.
[22]
Ibarretxe G, Crende O, Aurrekoetxea M, García-Murga V, Etxaniz J, Unda F. Neural crest stem cells from dental tissues: a new hope for dental and neural regeneration. Stem cells international. 2012; 2012.
[23]
Eslaminejad MB, Nazarian H, Shariati M, Vahabi S, Falahi F. Isolation and in vitro characterization of mesenchymal stem cells derived from the pulp tissue of human third molar tooth. Iranian Journal of Medical Sciences. 2015; 35(3): 216-25.
[24]
Perry BC, Zhou D, Wu X, Yang F-C, Byers MA, Chu T-MG, et al. Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Tissue Engineering Part C: Methods. 2008; 14(2): 149-56.
[25]
Pierdomenico L, Bonsi L, Calvitti M, Rondelli D, Arpinati M, Chirumbolo G, et al. Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp. Transplantation. 2005; 80(6): 836-42.
[26]
Zhao Q, Ren H, Han Z. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. Journal of Cellular Immunotherapy. 2015 (In Press).
[27]
Li Z, Jiang CM, An S, Cheng Q, Huang YF, Wang YT, et al. Immunomodulatory properties of dental tissue‐derived mesenchymal stem cells. Oral diseases. 2014; 20(1): 25-34.
[28]
Yamagata M, Yamamoto A, Kako E, Kaneko N, Matsubara K, Sakai K, et al. Human dental pulp-derived stem cells protect against hypoxic-ischemic brain injury in neonatal mice. Stroke. 2013; 44(2): 551-4.
[29]
Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M, et al. Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. The Journal of clinical investigation. 2012; 122(1): 80-90.
[30]
Woods EJ, Perry BC, Hockema JJ, Larson L, Zhou D, Goebel WS. Optimized cryopreservation method for human dental pulp-derived stem cells and their tissues of origin for banking and clinical use. Cryobiology. 2009; 59(2): 150-7.
[31]
Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P, et al. Comparative analysis of in vitro osteo/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP). Archives of oral biology. 2011; 56(7): 709-21.
[32]
Jesus AAd, Soares MBP, Soares AP, Nogueira RC, Guimarães ET, Araújo TMd, et al. Collection and culture of stem cells derived from dental pulp of deciduous teeth: technique and clinical case report. Dental Press Journal of Orthodontics. 2011; 16(6): 111-8.
[33]
de Mendonça Costa A, Bueno DF, Martins MT, Kerkis I, Kerkis A, Fanganiello RD, et al. Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. Journal of Craniofacial Surgery. 2008; 19(1): 204-10.
[34]
Seo B, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, et al. SHED repair critical‐size calvarial defects in mice. Oral diseases. 2008; 14(5): 428-34.
[35]
Seo B-M, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. The Lancet. 2004; 364(9429): 149-55.
[36]
Wang X, Sha X-J, Li G-H, Yang F-S, Ji K, Wen L-Y, et al. Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells. Archives of oral biology. 2012; 57(9): 1231-40.
[37]
Zhang Y, Chen Y. Bioengineering of a human whole tooth: progress and challenge. Cell Regeneration. 2014; 3(1): 1.
[38]
Shi S, Bartold P, Miura M, Seo B, Robey P, Gronthos S. The efficacy of mesenchymal stem cells to regenerate and repair dental structures. Orthodontics & craniofacial research. 2005; 8(3): 191-9.
[39]
Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences. 2003; 100(10): 5807-12.
[40]
Ponnaiyan D. Do dental stem cells depict distinct characteristics?—Establishing their “phenotypic fingerprint”. Dental research journal. 2014; 11(2): 163.
[41]
Yamaza T, Kentaro A, Chen C, Liu Y, Shi Y, Gronthos S, et al. Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. Stem cell research & therapy. 2010; 1(1): 5.
[42]
Nawi NSBM, Ariffín Z, Alam MK, Noor SNFM, Hassan A. The Assessment of Proliferation Rate of Dental Pulp Stem Cells and Stem Cell from Human Exfoliated Deciduous Teeth by Using Two Different Scaffold. International Medical Journal. 2013; 20(5): 593-6.
[43]
Behnia A, Haghighat A, Talebi A, Nourbakhsh N, Heidari F. Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect. World J Stem Cells. 2014; 6(4): 505-10.
[44]
Alipour R, Adib M, Karimi MM, Hashemi-Beni B, Sereshki N. Comparing the immunoregulatory effects of stem cells from human exfoliated deciduous teeth and bone marrow-derived mesenchymal stem cells. Iranian Journal of Allergy, Asthma and Immunology. 2013; 12(4): 331.
[45]
Kerkis I, Kerkis A, Dozortsev D, Stukart-Parsons GC, Gomes Massironi S, Pereira LV, et al. Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers. Cells Tissues Organs. 2007; 184(3-4): 105-16.
[46]
Koyama N, Okubo Y, Nakao K, Bessho K. Evaluation of pluripotency in human dental pulp cells. Journal of Oral and Maxillofacial Surgery. 2009; 67(3): 501-6.
[47]
Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one. 2006; 1(1): e79.
[48]
Tziafas D, Kodonas K. Differentiation potential of dental papilla, dental pulp, and apical papilla progenitor cells. Journal of endodontics. 2010; 36(5): 781-9.
[49]
Huang G-J, Gronthos S, Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. Journal of dental research. 2009; 88(9): 792-806.
[50]
Sowmya S, Chennazhi KP, Arzate H, Jayachandran P, Nair SV, Jayakumar R. Periodontal Specific Differentiation of Dental Follicle Stem Cells into Osteoblast, Fibroblast, and Cementoblast. Tissue Engineering Part C: Methods. 2015; 21(10): 1044-58.
[51]
Young M, Robey P, Wang C, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004; 364(9429): 149155.
[52]
Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis & Rheumatism. 2005; 52(8): 2521-9.
[53]
Wang F, Yu M, Yan X, Wen Y, Zeng Q, Yue W, et al. Gingiva-derived mesenchymal stem cell-mediated therapeutic approach for bone tissue regeneration. Stem cells and development. 2011; 20(12): 2093-102.
[54]
Tomar GB, Srivastava RK, Gupta N, Barhanpurkar AP, Pote ST, Jhaveri HM, et al. Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine. Biochemical and biophysical research communications. 2010; 393(3): 377-83.
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