Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy

Abdolreza Esmaeilzadeh; Elahe Reyhani; Nazila Bahmaie

doi:doi:10.11648/j.ijgg.20160406.14

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Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy

Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie

Published in International Journal of Genetics and Genomics (Volume 4, Issue 6)

Received: 1 March 2016 Accepted: 22 March 2016 Published: 22 March 2017

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Abstract

Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.

Published in	International Journal of Genetics and Genomics (Volume 4, Issue 6)
DOI	10.11648/j.ijgg.20160406.14
Page(s)	61-67
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dental Derived Stem Cells, Immunomodulation, Immune Markers, Cell Therapy, Tissue Reconstruction, Therapeutic Applications

References

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APA Style

Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie. (2017). Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. International Journal of Genetics and Genomics, 4(6), 61-67. https://doi.org/10.11648/j.ijgg.20160406.14

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ACS Style

Abdolreza Esmaeilzadeh; Elahe Reyhani; Nazila Bahmaie. Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. Int. J. Genet. Genomics 2017, 4(6), 61-67. doi: 10.11648/j.ijgg.20160406.14

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AMA Style

Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie. Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. Int J Genet Genomics. 2017;4(6):61-67. doi: 10.11648/j.ijgg.20160406.14

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@article{10.11648/j.ijgg.20160406.14,
  author = {Abdolreza Esmaeilzadeh and Elahe Reyhani and Nazila Bahmaie},
  title = {Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy},
  journal = {International Journal of Genetics and Genomics},
  volume = {4},
  number = {6},
  pages = {61-67},
  doi = {10.11648/j.ijgg.20160406.14},
  url = {https://doi.org/10.11648/j.ijgg.20160406.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20160406.14},
  abstract = {Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.},
 year = {2017}
}

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TY  - JOUR
T1  - Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy
AU  - Abdolreza Esmaeilzadeh
AU  - Elahe Reyhani
AU  - Nazila Bahmaie
Y1  - 2017/03/22
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20160406.14
DO  - 10.11648/j.ijgg.20160406.14
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 61
EP  - 67
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20160406.14
AB  - Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.
VL  - 4
IS  - 6
ER  -

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Author Information

Abdolreza Esmaeilzadeh

Immunology Department and Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Elahe Reyhani

Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran
Nazila Bahmaie

Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

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APA Style

Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie. (2017). Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. International Journal of Genetics and Genomics, 4(6), 61-67. https://doi.org/10.11648/j.ijgg.20160406.14

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ACS Style

Abdolreza Esmaeilzadeh; Elahe Reyhani; Nazila Bahmaie. Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. Int. J. Genet. Genomics 2017, 4(6), 61-67. doi: 10.11648/j.ijgg.20160406.14

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AMA Style

Abdolreza Esmaeilzadeh, Elahe Reyhani, Nazila Bahmaie. Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy. Int J Genet Genomics. 2017;4(6):61-67. doi: 10.11648/j.ijgg.20160406.14

Copy | Download

@article{10.11648/j.ijgg.20160406.14,
  author = {Abdolreza Esmaeilzadeh and Elahe Reyhani and Nazila Bahmaie},
  title = {Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy},
  journal = {International Journal of Genetics and Genomics},
  volume = {4},
  number = {6},
  pages = {61-67},
  doi = {10.11648/j.ijgg.20160406.14},
  url = {https://doi.org/10.11648/j.ijgg.20160406.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20160406.14},
  abstract = {Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.},
 year = {2017}
}

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TY  - JOUR
T1  - Immunobiology of Dental Tissue-Derived Stem Cells; As a Potentiated Candidate for Cell Therapy
AU  - Abdolreza Esmaeilzadeh
AU  - Elahe Reyhani
AU  - Nazila Bahmaie
Y1  - 2017/03/22
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20160406.14
DO  - 10.11648/j.ijgg.20160406.14
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 61
EP  - 67
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20160406.14
AB  - Background and aims: Mesenchymal stem cells (MSCs) are non-hematopoietic, undifferentiated, heterogeneous and multipotential stem cells population with immunosuppressive capacities in innate and acquired immune systems. During last decade, they have glisten in regenerative medicine. They can differentiate into various cell types and secrete soluble growth factors that impact on host immune system. One of these newly introduced stem cells, are Dental tissue derived Stem Cells (D-SCs). They are able to hold immunomodulatory and anti-inflammatory effects through cell-cell contact. Some of them are seen to be full of promising therapeutic applications. The aim of this study is to emphasize immune markers and biological effectiveness of these cells. Search method: Data of this study is collected from PubMed, Scopus, Science Direct databases and Google Scholar search engine by using 6 keywords (as: Dental derived Stem Cells, Immunomodulation, Immune markers, Cell therapy, Tissue reconstruction, Therapeutic applications) ultimately from 60 articles of 2000 up to 2016. Results: Some recent studies demonstrate that D-SCs render their immunomodulatory functions through soluble factors such as Prostaglandin E2 (PGE2), Indoleamine 2, 3-Dioxygenase (IDO), Transforming Growth Factor-β (TGF- β) and Human Leukocyte Antigen G5 (HLA-G5). Also, others do it by interactions between DSCs and immune cells such as T cells, B cells, macrophages, and dendritic cells. Conclusion: It appears that the immunomodulatory properties of dental MSCs is a promising window to cell-based therapy of immune and inflammation-related diseases.
VL  - 4
IS  - 6
ER  -

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