International Journal of Genetics and Genomics

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A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population

Received: 06 March 2017    Accepted:     Published: 10 March 2017
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Abstract

The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.

DOI 10.11648/j.ijgg.20170501.12
Published in International Journal of Genetics and Genomics (Volume 5, Issue 1, February 2017)
Page(s) 14-18
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

9p21 Locus, Ischemic Stroke, Chinese, Genetic Association Study

References
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Author Information
  • Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada; Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, P. R. China

  • Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, P. R. China

  • Department of Genetics, Faculty of Medicine, Zhengzhou University, Zhengzhou, P. R. China

  • Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

  • Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, P. R. China

  • Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

  • Disciplines of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

  • Disciplines of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

  • Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada; Disciplines of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

  • Disciplines of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada; Disciplines of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada; Disciplines of Pediatrics, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada; Disciplines of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada

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    Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. (2017). A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. International Journal of Genetics and Genomics, 5(1), 14-18. https://doi.org/10.11648/j.ijgg.20170501.12

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    ACS Style

    Shuo Li; Yu-Ming Xu; Hong Zheng; Edward Randell; Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int. J. Genet. Genomics 2017, 5(1), 14-18. doi: 10.11648/j.ijgg.20170501.12

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    AMA Style

    Shuo Li, Yu-Ming Xu, Hong Zheng, Edward Randell, Hai-Zheng Wang, et al. A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population. Int J Genet Genomics. 2017;5(1):14-18. doi: 10.11648/j.ijgg.20170501.12

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  • @article{10.11648/j.ijgg.20170501.12,
      author = {Shuo Li and Yu-Ming Xu and Hong Zheng and Edward Randell and Hai-Zheng Wang and Jianxun Cui and Guang Sun and Guangju Zhai and Fei-Yu Han and Ya-Gang Xie},
      title = {A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population},
      journal = {International Journal of Genetics and Genomics},
      volume = {5},
      number = {1},
      pages = {14-18},
      doi = {10.11648/j.ijgg.20170501.12},
      url = {https://doi.org/10.11648/j.ijgg.20170501.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijgg.20170501.12},
      abstract = {The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - A Reduced Interval of Chromosome 9p21 Locus is Associated with Ischemic Stroke in Chinese Northern Han Population
    AU  - Shuo Li
    AU  - Yu-Ming Xu
    AU  - Hong Zheng
    AU  - Edward Randell
    AU  - Hai-Zheng Wang
    AU  - Jianxun Cui
    AU  - Guang Sun
    AU  - Guangju Zhai
    AU  - Fei-Yu Han
    AU  - Ya-Gang Xie
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    DO  - 10.11648/j.ijgg.20170501.12
    T2  - International Journal of Genetics and Genomics
    JF  - International Journal of Genetics and Genomics
    JO  - International Journal of Genetics and Genomics
    SP  - 14
    EP  - 18
    PB  - Science Publishing Group
    SN  - 2376-7359
    UR  - https://doi.org/10.11648/j.ijgg.20170501.12
    AB  - The 9p21 locus, a strong risk locus for coronary arterial disease, has been also associated with other cardiovascular disease including ischemic stroke (IS) in Caucasians. However, the association between 9p21 locus and IS in Chinese Han population is still debatable because of ambiguous results reported previously. Genetic heterogeneity between Southern and Northern Chinese Han populations could be one of the reasons for this uncertainty. Four genetic variants selected from the three conjunctional LD blocks within the 44 kb candidate region on chromosome 9p21 were genotyped in 1,429 IS patients and 1,191 healthy controls from the Northern Chinese Han population. Among the four studied variants, the G allele of the SNP rs2383207 was significantly associated with IS with allele frequency 66.8% in patients and 63.4% in controls. This association appears to be dominant with an OR of 1.417 (p=0.003) for people with either GG or AG genotypes. We did not find any association for the other three SNPs (rs1333049, rs10757274, and rs10116277). Based our results, we conclude that the 9p21 locus is a susceptibility locus for IS in the Northern Chinese Han population; and the core risk region for IS is within an interval of less than 28kb.
    VL  - 5
    IS  - 1
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