Identification of human disease genes can be accomplished by two strategies: functional cloning and positional cloning. Genetic mapping is the localization of genes underlying phenotypes on the basis of correlation with DNA variation, without the need for prior hypotheses about biological function and the simplest form, called linkage analysis. The ability to clone and sequence DNA made it possible to tie genetic linkage maps in model organisms to the underlying DNA sequence. In conclusion particular alleles at neighboring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles known as linkage disequilibrium (LD). Considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases.
| Published in | International Journal of Genetics and Genomics (Volume 2, Issue 4) |
| DOI | 10.11648/j.ijgg.20140204.14 |
| Page(s) | 68-76 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Human Disease Genes, Functional Cloning, Positional Cloning, Genetic Mapping, Mendelian Trait, Linkage Disequilibrium (LD)
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APA Style
Nahid Askari, Amin Baghizadeh. (2014). Linkage Disequilibrium and the Mapping of Human Disease Genes. International Journal of Genetics and Genomics, 2(4), 68-76. https://doi.org/10.11648/j.ijgg.20140204.14
ACS Style
Nahid Askari; Amin Baghizadeh. Linkage Disequilibrium and the Mapping of Human Disease Genes. Int. J. Genet. Genomics 2014, 2(4), 68-76. doi: 10.11648/j.ijgg.20140204.14
AMA Style
Nahid Askari, Amin Baghizadeh. Linkage Disequilibrium and the Mapping of Human Disease Genes. Int J Genet Genomics. 2014;2(4):68-76. doi: 10.11648/j.ijgg.20140204.14
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Download@article{10.11648/j.ijgg.20140204.14,
author = {Nahid Askari and Amin Baghizadeh},
title = {Linkage Disequilibrium and the Mapping of Human Disease Genes},
journal = {International Journal of Genetics and Genomics},
volume = {2},
number = {4},
pages = {68-76},
doi = {10.11648/j.ijgg.20140204.14},
url = {https://doi.org/10.11648/j.ijgg.20140204.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20140204.14},
abstract = {Identification of human disease genes can be accomplished by two strategies: functional cloning and positional cloning. Genetic mapping is the localization of genes underlying phenotypes on the basis of correlation with DNA variation, without the need for prior hypotheses about biological function and the simplest form, called linkage analysis. The ability to clone and sequence DNA made it possible to tie genetic linkage maps in model organisms to the underlying DNA sequence. In conclusion particular alleles at neighboring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles known as linkage disequilibrium (LD). Considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases.},
year = {2014}
}
TY - JOUR T1 - Linkage Disequilibrium and the Mapping of Human Disease Genes AU - Nahid Askari AU - Amin Baghizadeh Y1 - 2014/08/20 PY - 2014 N1 - https://doi.org/10.11648/j.ijgg.20140204.14 DO - 10.11648/j.ijgg.20140204.14 T2 - International Journal of Genetics and Genomics JF - International Journal of Genetics and Genomics JO - International Journal of Genetics and Genomics SP - 68 EP - 76 PB - Science Publishing Group SN - 2376-7359 UR - https://doi.org/10.11648/j.ijgg.20140204.14 AB - Identification of human disease genes can be accomplished by two strategies: functional cloning and positional cloning. Genetic mapping is the localization of genes underlying phenotypes on the basis of correlation with DNA variation, without the need for prior hypotheses about biological function and the simplest form, called linkage analysis. The ability to clone and sequence DNA made it possible to tie genetic linkage maps in model organisms to the underlying DNA sequence. In conclusion particular alleles at neighboring loci tend to be co-inherited. For tightly linked loci, this might lead to associations between alleles known as linkage disequilibrium (LD). Considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases. VL - 2 IS - 4 ER -
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