Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus

Dalia Abdul-Halim Shaheen; Hisham M. Habib; Mohamed A. Marie

doi:doi:10.11648/j.ijgg.20150305.13

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Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus

Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie

Published in International Journal of Genetics and Genomics (Volume 3, Issue 5)

Received: 12 August 2015 Accepted: 28 August 2015 Published: 17 September 2015

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Abstract

Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. Objective. To detect the serum level as well as expression in PBMCs in the blood of IL-6 in SLE patients. Furthermore we compare serum level, as well as expression in PBMCs in the blood of IL-6 of lupus nephritis group versus non-nephritis lupus group and to study its correlation with other variables in SLE patients. Methods. The study was carried on 100 SLE patients, and 50 healthy control subjects. Fifty patients had lupus nephritis and 50 without evidence of lupus nephritis. Serum interleukin 6 (IL6) was measured using the ELISA technique as well as the expression of IL6 mRNA in PBMCs. Serum creatinine, C3, C4 and 24 hours urinary proteins were measured. Lupus activity was assessed using BILAG scoring system. Renal activity was measured using renal activity scoring system. Results. Serum IL6 level and its mRNA expression was significantly high in SLE patients and was higher in lupus nephritis patients than lupus patients without nephritis. IL6 was significantly correlated with renal activity score, 24 hours urinary proteins lowered C3 and C4 level and BILAG score. Conclusion. Serum IL-6 level and its mRNA expression is elevated in SLE patients as well as lupus nephritis patients. This was found to be linked with SLE disease activity in general and renal involvement in particular.

Published in	International Journal of Genetics and Genomics (Volume 3, Issue 5)
DOI	10.11648/j.ijgg.20150305.13
Page(s)	53-58
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Autoimmune, Cytokines, IL 6, SLE

References

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Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie. (2015). Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. International Journal of Genetics and Genomics, 3(5), 53-58. https://doi.org/10.11648/j.ijgg.20150305.13

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ACS Style

Dalia Abdul-Halim Shaheen; Hisham M. Habib; Mohamed A. Marie. Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. Int. J. Genet. Genomics 2015, 3(5), 53-58. doi: 10.11648/j.ijgg.20150305.13

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AMA Style

Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie. Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. Int J Genet Genomics. 2015;3(5):53-58. doi: 10.11648/j.ijgg.20150305.13

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@article{10.11648/j.ijgg.20150305.13,
  author = {Dalia Abdul-Halim Shaheen and Hisham M. Habib and Mohamed A. Marie},
  title = {Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus},
  journal = {International Journal of Genetics and Genomics},
  volume = {3},
  number = {5},
  pages = {53-58},
  doi = {10.11648/j.ijgg.20150305.13},
  url = {https://doi.org/10.11648/j.ijgg.20150305.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20150305.13},
  abstract = {Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. Objective. To detect the serum level as well as expression in PBMCs in the blood of IL-6 in SLE patients. Furthermore we compare serum level, as well as expression in PBMCs in the blood of IL-6 of lupus nephritis group versus non-nephritis lupus group and to study its correlation with other variables in SLE patients. Methods. The study was carried on 100 SLE patients, and 50 healthy control subjects. Fifty patients had lupus nephritis and 50 without evidence of lupus nephritis. Serum interleukin 6 (IL6) was measured using the ELISA technique as well as the expression of IL6 mRNA in PBMCs. Serum creatinine, C3, C4 and 24 hours urinary proteins were measured. Lupus activity was assessed using BILAG scoring system. Renal activity was measured using renal activity scoring system. Results. Serum IL6 level and its mRNA expression was significantly high in SLE patients and was higher in lupus nephritis patients than lupus patients without nephritis. IL6 was significantly correlated with renal activity score, 24 hours urinary proteins lowered C3 and C4 level and BILAG score. Conclusion. Serum IL-6 level and its mRNA expression is elevated in SLE patients as well as lupus nephritis patients. This was found to be linked with SLE disease activity in general and renal involvement in particular.},
 year = {2015}
}

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TY - JOUR
T1 - Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus
AU - Dalia Abdul-Halim Shaheen
AU - Hisham M. Habib
AU - Mohamed A. Marie
Y1 - 2015/09/17
PY - 2015
N1 - https://doi.org/10.11648/j.ijgg.20150305.13
DO - 10.11648/j.ijgg.20150305.13
T2 - International Journal of Genetics and Genomics
JF - International Journal of Genetics and Genomics
JO - International Journal of Genetics and Genomics
SP - 53
EP - 58
PB - Science Publishing Group
SN - 2376-7359
UR - https://doi.org/10.11648/j.ijgg.20150305.13
AB - Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. Objective. To detect the serum level as well as expression in PBMCs in the blood of IL-6 in SLE patients. Furthermore we compare serum level, as well as expression in PBMCs in the blood of IL-6 of lupus nephritis group versus non-nephritis lupus group and to study its correlation with other variables in SLE patients. Methods. The study was carried on 100 SLE patients, and 50 healthy control subjects. Fifty patients had lupus nephritis and 50 without evidence of lupus nephritis. Serum interleukin 6 (IL6) was measured using the ELISA technique as well as the expression of IL6 mRNA in PBMCs. Serum creatinine, C3, C4 and 24 hours urinary proteins were measured. Lupus activity was assessed using BILAG scoring system. Renal activity was measured using renal activity scoring system. Results. Serum IL6 level and its mRNA expression was significantly high in SLE patients and was higher in lupus nephritis patients than lupus patients without nephritis. IL6 was significantly correlated with renal activity score, 24 hours urinary proteins lowered C3 and C4 level and BILAG score. Conclusion. Serum IL-6 level and its mRNA expression is elevated in SLE patients as well as lupus nephritis patients. This was found to be linked with SLE disease activity in general and renal involvement in particular.
VL - 3
IS - 5
ER -

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Author Information

Dalia Abdul-Halim Shaheen

Department of Medical Biochemistry, Faculty of Medicine, Mansoura University, Cairo, Egypt
Hisham M. Habib

Department of Rheumatology and Rehabilitation, Faculty of Medicine, Mansoura University, Cairo, Egypt
Mohamed A. Marie

Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

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Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie. (2015). Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. International Journal of Genetics and Genomics, 3(5), 53-58. https://doi.org/10.11648/j.ijgg.20150305.13

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ACS Style

Dalia Abdul-Halim Shaheen; Hisham M. Habib; Mohamed A. Marie. Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. Int. J. Genet. Genomics 2015, 3(5), 53-58. doi: 10.11648/j.ijgg.20150305.13

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AMA Style

Dalia Abdul-Halim Shaheen, Hisham M. Habib, Mohamed A. Marie. Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus. Int J Genet Genomics. 2015;3(5):53-58. doi: 10.11648/j.ijgg.20150305.13

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@article{10.11648/j.ijgg.20150305.13,
  author = {Dalia Abdul-Halim Shaheen and Hisham M. Habib and Mohamed A. Marie},
  title = {Interleukin-6: A Proinflammatory Role in Nephritis in Patients with Systemic Lupus Erythematosus},
  journal = {International Journal of Genetics and Genomics},
  volume = {3},
  number = {5},
  pages = {53-58},
  doi = {10.11648/j.ijgg.20150305.13},
  url = {https://doi.org/10.11648/j.ijgg.20150305.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20150305.13},
  abstract = {Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. Objective. To detect the serum level as well as expression in PBMCs in the blood of IL-6 in SLE patients. Furthermore we compare serum level, as well as expression in PBMCs in the blood of IL-6 of lupus nephritis group versus non-nephritis lupus group and to study its correlation with other variables in SLE patients. Methods. The study was carried on 100 SLE patients, and 50 healthy control subjects. Fifty patients had lupus nephritis and 50 without evidence of lupus nephritis. Serum interleukin 6 (IL6) was measured using the ELISA technique as well as the expression of IL6 mRNA in PBMCs. Serum creatinine, C3, C4 and 24 hours urinary proteins were measured. Lupus activity was assessed using BILAG scoring system. Renal activity was measured using renal activity scoring system. Results. Serum IL6 level and its mRNA expression was significantly high in SLE patients and was higher in lupus nephritis patients than lupus patients without nephritis. IL6 was significantly correlated with renal activity score, 24 hours urinary proteins lowered C3 and C4 level and BILAG score. Conclusion. Serum IL-6 level and its mRNA expression is elevated in SLE patients as well as lupus nephritis patients. This was found to be linked with SLE disease activity in general and renal involvement in particular.},
 year = {2015}
}

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