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Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control

Ziyad Tariq Muhseen
Received: 11 August 2014    Accepted: 26 August 2014    Published: 10 November 2014
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Abstract

Mitochondria are responsible for the essential role in the cell survival by regulating the cellular energy, homeostasis, oxidative phosphorylation process, fatty acid oxidation and in the cell death process by regulating apoptosis. However, reactive oxygen species (ROS) is produced by mitochondria that pose oxidative damage to lipids, protein and mitochondrial DNA and additional production of ROS is triggered by this damage. On the other hand, the host cell control the life and death of mitochondria that include degradation, fission and growth. Recent research has been focused on the autophagic degradation of mitochondria, which is also mitophagy that results in significant discovery of the mechanism, function and regulation of mitophagy in eukaryotic cell especially in budding yeast. Mitophagy has been found to be important quality control mechanism for mitochondria. It has a key role in the eliminating of damaged mitochondria. Many studies have been done to unravel the mechanism and regulatory features of proteins involved in mitophagy but the results are inconsistent and conflicting. Mitochondrial surface receptor involved in mitochondrial autophagy has been recently identified using yeast genetics. Recent studies have been discovered specific regulators of Mitophagy that ensure selective sequestration of mitochondria as cargo. According to our understanding, in this paper we will review recent advances of different pathways of Mitophagy in the yeast. We will review the main proteins which play an essential role in controlling this process and the main pathways which lead to a highly controlled Mitophagy process.

DOI 10.11648/j.ejb.20140205.11
Published in European Journal of Biophysics (Volume 2, Issue 5, October 2014)
Page(s) 49-60
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

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Keywords

Mitochondria, Mitophagy, Yeast, Autophagy

References
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    Ziyad Tariq Muhseen. (2014). Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control. European Journal of Biophysics, 2(5), 49-60. https://doi.org/10.11648/j.ejb.20140205.11

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    Ziyad Tariq Muhseen. Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control. Eur. J. Biophys. 2014, 2(5), 49-60. doi: 10.11648/j.ejb.20140205.11

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    Ziyad Tariq Muhseen. Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control. Eur J Biophys. 2014;2(5):49-60. doi: 10.11648/j.ejb.20140205.11

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  • @article{10.11648/j.ejb.20140205.11,
  author = {Ziyad Tariq Muhseen},
  title = {Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control},
  journal = {European Journal of Biophysics},
  volume = {2},
  number = {5},
  pages = {49-60},
  doi = {10.11648/j.ejb.20140205.11},
  url = {https://doi.org/10.11648/j.ejb.20140205.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejb.20140205.11},
  abstract = {Mitochondria are responsible for the essential role in the cell survival by regulating the cellular energy, homeostasis, oxidative phosphorylation process, fatty acid oxidation and in the cell death process by regulating apoptosis. However, reactive oxygen species (ROS) is produced by mitochondria that pose oxidative damage to lipids, protein and mitochondrial DNA and additional production of ROS is triggered by this damage. On the other hand, the host cell control the life and death of mitochondria that include degradation, fission and growth. Recent research has been focused on the autophagic degradation of mitochondria, which is also mitophagy that results in significant discovery of the mechanism, function and regulation of mitophagy in eukaryotic cell especially in budding yeast. Mitophagy has been found to be important quality control mechanism for mitochondria. It has a key role in the eliminating of damaged mitochondria. Many studies have been done to unravel the mechanism and regulatory features of proteins involved in mitophagy but the results are inconsistent and conflicting. Mitochondrial surface receptor involved in mitochondrial autophagy has been recently identified using yeast genetics. Recent studies have been discovered specific regulators of Mitophagy that ensure selective sequestration of mitochondria as cargo. According to our understanding, in this paper we will review recent advances of different pathways of Mitophagy in the yeast. We will review the main proteins which play an essential role in controlling this process and the main pathways which lead to a highly controlled Mitophagy process.},
 year = {2014}
}

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  • TY  - JOUR
T1  - Selective Mitophagy in Budding Yeast, a Mitochondrial Self-Eating Quality Control
AU  - Ziyad Tariq Muhseen
Y1  - 2014/11/10
PY  - 2014
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DO  - 10.11648/j.ejb.20140205.11
T2  - European Journal of Biophysics
JF  - European Journal of Biophysics
JO  - European Journal of Biophysics
SP  - 49
EP  - 60
PB  - Science Publishing Group
SN  - 2329-1737
UR  - https://doi.org/10.11648/j.ejb.20140205.11
AB  - Mitochondria are responsible for the essential role in the cell survival by regulating the cellular energy, homeostasis, oxidative phosphorylation process, fatty acid oxidation and in the cell death process by regulating apoptosis. However, reactive oxygen species (ROS) is produced by mitochondria that pose oxidative damage to lipids, protein and mitochondrial DNA and additional production of ROS is triggered by this damage. On the other hand, the host cell control the life and death of mitochondria that include degradation, fission and growth. Recent research has been focused on the autophagic degradation of mitochondria, which is also mitophagy that results in significant discovery of the mechanism, function and regulation of mitophagy in eukaryotic cell especially in budding yeast. Mitophagy has been found to be important quality control mechanism for mitochondria. It has a key role in the eliminating of damaged mitochondria. Many studies have been done to unravel the mechanism and regulatory features of proteins involved in mitophagy but the results are inconsistent and conflicting. Mitochondrial surface receptor involved in mitochondrial autophagy has been recently identified using yeast genetics. Recent studies have been discovered specific regulators of Mitophagy that ensure selective sequestration of mitochondria as cargo. According to our understanding, in this paper we will review recent advances of different pathways of Mitophagy in the yeast. We will review the main proteins which play an essential role in controlling this process and the main pathways which lead to a highly controlled Mitophagy process.
VL  - 2
IS  - 5
ER  -

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  • Ziyad Tariq Muhseen

    Key Laboratory of Molecular Biophysics, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Rd., Wuhan 430074, Hubei, China

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