European Journal of Biophysics

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A Hybrid Continuous-Discrete Model of Tumour-Induced Angiogenesis is Solved Numerically in Parallel and Performance Improvements Analysed

Received: 30 August 2015    Accepted: 22 September 2015    Published: 13 October 2015
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Abstract

The main aim of this paper is to investigate the potential performance improvements gained from a serial versus parallel implementation of the numerical solution to a system of coupled nonlinear PDEs describing tumour-induced angiogenesis. After applying a suitable finite difference scheme, the resulting hybrid continuous discreet model is solved based on a set of cellular rules defining endothelial cell movement towards a tumour. In addition, the model explicitly incorporates the processes of branching, anastomosis and cell proliferation. Parallel implementations are based on the CUDA programming model with a detailed look at efficient thread deployment and memory management. Results show substantial speedups for the CUDA C language against that of conventional high performance languages, such as C++. Such increased performance highlights the potential for simulating more complex mathematical models of tumour dynamics, such as vascularisation networks, tumour invasion and metastasis, leading to the potential for more rapid experimental results for a range of complex cancer models.

DOI 10.11648/j.ejb.20150305.11
Published in European Journal of Biophysics (Volume 3, Issue 5, October 2015)
Page(s) 27-37
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cancer Modelling, Tumour Angiogenic Factors (TAF), Tumour-Induced Angiogenesis, Anastomoses, Parallel Programming, Compute Unified Device Architecture (CUDA), Graphical Processing Unit (GPU), High Performance Computing (HPC)

References
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Author Information
  • Department of Computational Biophysics, Algenet Cancer Research, Nottingham, UK

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    Paul M. Darbyshire. (2015). A Hybrid Continuous-Discrete Model of Tumour-Induced Angiogenesis is Solved Numerically in Parallel and Performance Improvements Analysed. European Journal of Biophysics, 3(5), 27-37. https://doi.org/10.11648/j.ejb.20150305.11

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    Paul M. Darbyshire. A Hybrid Continuous-Discrete Model of Tumour-Induced Angiogenesis is Solved Numerically in Parallel and Performance Improvements Analysed. Eur. J. Biophys. 2015, 3(5), 27-37. doi: 10.11648/j.ejb.20150305.11

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    AMA Style

    Paul M. Darbyshire. A Hybrid Continuous-Discrete Model of Tumour-Induced Angiogenesis is Solved Numerically in Parallel and Performance Improvements Analysed. Eur J Biophys. 2015;3(5):27-37. doi: 10.11648/j.ejb.20150305.11

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  • @article{10.11648/j.ejb.20150305.11,
      author = {Paul M. Darbyshire},
      title = {A Hybrid Continuous-Discrete Model of Tumour-Induced Angiogenesis is Solved Numerically in Parallel and Performance Improvements Analysed},
      journal = {European Journal of Biophysics},
      volume = {3},
      number = {5},
      pages = {27-37},
      doi = {10.11648/j.ejb.20150305.11},
      url = {https://doi.org/10.11648/j.ejb.20150305.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ejb.20150305.11},
      abstract = {The main aim of this paper is to investigate the potential performance improvements gained from a serial versus parallel implementation of the numerical solution to a system of coupled nonlinear PDEs describing tumour-induced angiogenesis. After applying a suitable finite difference scheme, the resulting hybrid continuous discreet model is solved based on a set of cellular rules defining endothelial cell movement towards a tumour. In addition, the model explicitly incorporates the processes of branching, anastomosis and cell proliferation. Parallel implementations are based on the CUDA programming model with a detailed look at efficient thread deployment and memory management. Results show substantial speedups for the CUDA C language against that of conventional high performance languages, such as C++. Such increased performance highlights the potential for simulating more complex mathematical models of tumour dynamics, such as vascularisation networks, tumour invasion and metastasis, leading to the potential for more rapid experimental results for a range of complex cancer models.},
     year = {2015}
    }
    

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    AB  - The main aim of this paper is to investigate the potential performance improvements gained from a serial versus parallel implementation of the numerical solution to a system of coupled nonlinear PDEs describing tumour-induced angiogenesis. After applying a suitable finite difference scheme, the resulting hybrid continuous discreet model is solved based on a set of cellular rules defining endothelial cell movement towards a tumour. In addition, the model explicitly incorporates the processes of branching, anastomosis and cell proliferation. Parallel implementations are based on the CUDA programming model with a detailed look at efficient thread deployment and memory management. Results show substantial speedups for the CUDA C language against that of conventional high performance languages, such as C++. Such increased performance highlights the potential for simulating more complex mathematical models of tumour dynamics, such as vascularisation networks, tumour invasion and metastasis, leading to the potential for more rapid experimental results for a range of complex cancer models.
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