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Prevalence and Antimicrobial Susceptibility Pattern of Urinary Tract Infection(UTI) among Pregnant Women in Afikpo, Ebonyi State, Nigeria
American Journal of Life Sciences
Volume 2, Issue 2, April 2014, Pages: 46-52
Received: Jan. 2, 2014; Published: Mar. 20, 2014
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Stanley Chukwudozie Onuoha, Department of Biotechnology, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria
Kayode Fatokun, Department of Agriculture, University of Zululand, KwaDlangezwa, South Africa
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Urinary Tract Infections (UTIs) describe the microbial invasion and subsequent multiplication on a part or the entire urinary tract. Urinary Tract Infection (UTI) has become the most common bacterial infections in humans, both at the community and hospital settings. The present study was a hospital-based surveillance conducted in four selected hospitals in Afikpo to assess the prevalence and antimicrobial susceptibility of bacteria from suspected urinary tract infections. A cross-sectional study was conducted on the urine of pregnant women with UTI attending the outpatient clinics between April-August 2013. A total of 200 clean midstream urine samples were collected and a general urine microscopic examination and culture were carried out, information on their age, gestational age, gravidity, parity, level of education and residence were also collected. Susceptibility testing panels of the following antibiotics: Gentamycin, tetracycline amikacin, ampicillin, erythromycin, nalidixic acid, ciprofloxacin, cotrimaxasole and cefaloxine were tested against the isolated organisms using disc diffusion method. The bacteriologic agents of UTI isolated from the patients showed that Escherichia coli was the most frequently isolated organism (50.0%) and it is followed by Staphylococcus aureus (17.3%), Proteus mirabilis (5.5%), Pseudomonas aeruginosa (2.7%) and Enterococcus faecalis (1.8%). The distribution of UTI among the ages of the antenatal patients showed that age group within the range of 27-32 years recorded the highest incidence of UTI, whereas those of them above 39 years showed the least incidence. Ciprofloxacin, Gentamycin and Erythromycin were the most active antibiotics, while the isolates were highly resistant to cotrimoxasole, cefaloxine and nalidixic acid. Urinary tract infection is a major health problem among pregnant women. Urinalysis with culture and sensitivity test is the major diagnostic measure, while health education with regular antenatal and personal hygiene is recommended as precautionary measures to UTI.
Pregnancy, Urinary Tract Infection, Culture, Sensitivity Test, Afikpo
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Stanley Chukwudozie Onuoha, Kayode Fatokun, Prevalence and Antimicrobial Susceptibility Pattern of Urinary Tract Infection(UTI) among Pregnant Women in Afikpo, Ebonyi State, Nigeria, American Journal of Life Sciences. Vol. 2, No. 2, 2014, pp. 46-52. doi: 10.11648/j.ajls.20140202.12
Adeleke, M.A., W.O. Adebimpe, S.O. Sam-Wobo, A. Wahab and L.S. Akinyosoye et al., 2013. Sero-prevalence of malaria, hepatitis b and syphilis among pregnant women. Am. J. Microbiol., 4: 20-23
Adedeji, B.A.M and O.A. Abdulkadir.2009. Etiology and antimicrobial resistance pattern of bacterial agents of urinary tract infections in students of tertiary Institutions in Yola Metropolis. Adv Biol. Reseach., 3(3-4):67-70.
Akerele, J., P. Abhlimen and F. Okonofua. 2002. Prevalence of asymptomatic bacteriuria among pregnant women in Benin city., British J. Obstetric Gynecol..,221(2): 141-144.
Aiyegoro, O.A., O.O.Igbinosa, I.N. Ogunmwoniyi, E.E. Odjadjare, O.E. Igbinosa and A.I. Okoh. 2007. Incidence of urinary tract infections (UTI) among children and adolescents in Ile-Ife, Nigeria.Afri. J. Microbiol. Res.,13-19
Arpi, M. and J. Rennerg. 1984. The clinical significance of Staphylococcus aureus bacteriuria. J. Urology., 132(4):697-700.
Akinloye,O., D.O.Ogbolu, O.M.Akinloye and O.A.Terry Alli.2006.Asymptomatic bacteriauria of pregnancy I Ibadan,nigeria: a re-assessment. Br. J Biom. Sci., 63(3):109-12.
Al sweih, N., W. Jamal and V.O. Rotimi. 2005. Spectrum and antibiotic resistance of uropathogens isolated from hospital and community patients with urinary tract infection in 2 large hospitals in Kuwait., Med. Princ. Practice, 14(6):401-407.
Bauer, A.W., W.M.M. Kirby, J. C. Sherris and M. Turck, 1966. Antibiotic susceptibility testing by standard single disc method. Am J. Clinical Pathol., 45: 493-496
Bacak, S.J., W.M. Callaghan, P.M. Dietz, C. Crouse, 2005. Pregnancy-associated hospitalizations in the United States, 1999-2000. American Journal Obstetrics and Gynecology.,192(2):592-597.
Bahadin, J., S.S.S. Teo and S. Mathew.2011. Aetiology of community –acquired urinary tract infection and antimicrobial susceptibility patterns of uropathogens isolated. Singapore Med. J.,52:415-420.
Basu, J.K., C.M. Jeketera and D. Basu.2010. Obesty and its outcome among pregnant South African women. In J. Obstet Gynaecol., 110(2):101-4.
Cheesbrough, M.C., 2006. District Laboratory Practice in Tropical Countries. 1st Edn., Cambridge University Press, Cambridge, UK. pp: 115.
Dalela, G., S. Gupta, D.K.jain and P. Mehta.2012. antibiotic resistance pattern in uropathogen at a tertiay care hospital at Jhalawar with special refernce to ESBL, Ampc β- lactamase and MRSA production. J Clin. Diag Res., 6:645-651.
Delzell, J.E. and M.L. Lefevre, 2000. Urinary tract infection during pregnancy. Am. Family Phy., 61(3): 713-721.
De Francesco, M.A., R. Guiseppe, P.Laura, N.Ricardo and M. Nino. 2007.urinary tract infection in Brescia, Italy: Etiology of Uropathogens and antimicrobial resistance of common uropathogens Med. Sci Monit., 13:136-144.
Demile, T., G. Beyene, S. Melaku and W. Tsegaye. 2012. Urinary bacterial profile and antibiotic susceptibilty pattern among pregnant women in North West Ethiopia. Ethiopian J. Health Sci., 22: 121-128
Desai, P., P.M.ukey, A.R.Chauhan, S.Malik and M.Mathur. 2012. Etiology and antimicrobial resistance patterns of uropathogen in a hospital in a suburb of Mumbai. Int. J.Biol Med Res., 3:2007-2012.
Dimetry, S.R., H.M. El-Tokhy, N.M. Abdo, M.A. Ebrahim, and M.Eissa.2007. Urinary tract infection and adverse outcome of pregnancy. J. Egypt Public Health Assoc., 82(3-4):203-18
Haider, H., N. Zehia, A.A. Munir and A. Haider.2010. a risk factor for urinary tract infection in pregnancy. J.Pakistan Med. Assoc., 60:213-216.
Hamdan, H.Z., A.B.M. Ziad,S.K. Ali and I. Adams.2011. Epidemiology of urinary tract infections and antibiotic sensitivty among pregnant women at Khartoun North Hospital. Annal Clin. Microbiol. Antimicrob., 10:2
Johnson, K.E. and E.D. Kim, 2012. Urinary tract infections in pregnancy. e/452604-overview
Kolawole, A.S., O.M. Kolawole, Y.T. Kandaki-olukemi and S.K. Babatunde, K. A Durowade and C.F. Kolawole, 2009. Prevalence of urinary tract infections among patients attending Dalhatu Araf Specialist Hospital, Lafia, Nassarawa State, Nigeria. Int. J. Medicinal Med. Sci., 1(5): 163-167.
Kashef, N., G.E Djavid and S. Shahhbazi. 2010.Antimicrobial susceptibility patterns of community acqired uropathogen in Tehran .Iran J. Infect Dev Ctries.,4:202-206.
Leegard, T.M., D.A.Caugant, L.O. Froholm and E.A. Hoiby.2000.Apparent difference in antimicrobial susceptibility as a consequence of national guidelines.Clin Microbiol Infect., 6:290
Loh, K.Y and L. Silvalingan, 2007. Urinary tract infections in pregnancy. Malaysian family physician., 2(2): 54-57.
Moghadas, A.J. and G. Irajian, 2009. Asymptomatic urinary tract infection in pregnant women. J. Pathol., 4: 42-46.
Mobasheri, E.T., A. Abbaraei, E.M. Ghaemi Mojerloo, M. Vakili and M. Dastfooshan, 2012. Distribution of asymptomatic bacteriuria in pregnant women referring to Dezyari Hospital in Jordan. J. Jordan University Med. Sci., 4: 42-46.
Mulugeta,K and A. Bayeh. 2014. Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health research Laboratory , Ethiopia. Asian Pac. J Trop Biomed., 4(2):164-168
Nerurkar, A., P. Solanky and S.S. Naik. 2012. Bacterial pathogen in urinary tract infection and antimicrobial susceptibility pattern. J.Pharm Biomed Sci., 21:1-3.
Okonko, I.O., L.A. Ijanipe, O.A.Ilusanya, O.B. Donbraye-Emmanuel et al., 2009. Incidence of urinary tract infection(UTI) among pregnant women in Ibadan, south-Western, Nigeria. Afr J. Biotech., 8(23):6649-6657.
Onifade, A.K.., F.O. Omoya and D.V. Adegunloye, 2005. Incidence and control of urinary tract infection in women attending antenatal clinics in government hospitals in Ondo State, Nigeria. J. Food, Agric Environ., 3(1): 37-38.
Onuh, S.O., O.U.J. Umeora, G.O. Igberase, M.E. Azikem and E.E. Okpere. 2006. Microbiological Isolates and sensitivity pattern of Urinary tract infection in pregnancy in Benin city. Ebonyi Medical Journal., 5(2): 48-52.
Patterson, T.F. and V.T. Andriole, 1987. Bacteruiria in pregnancy., Infect Dis Clin North Am., 1: 807-822.
Sood, S.and R. Gupta. 2012. Antbiotic resistance pattern of community acquired uropathogens at a tertiary care hospital in Jaipur Rajasitan. Indian J. Comm Medi., 37: 39-44.
Theodros,G. 2010. Bacterial pathogens implicated in causing urinary tract infection(UTI) and their antimicrobial susceptibility pattern in Ethiopia. Revista CENIC.Ciencias Biologicas., 41:1-6.
Mbata, T. 2007. Prevalence and antibiogram of urinary tract infections among prison inmates in Nigeria.The Internet . J. Microbiol., 3(2):12-23.
Valiquette, L., 2001. Urinary tract infection in women. J. Urol., 8: 6-12.
Weichhart, T., M. Haidinger, W.H. Horl and M.D. Saemann. 2008. Current concepts of molecular defence mechanisms operative during urinary tract infection. Eur J. Clin Invest.,38:29-38.
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