American Journal of Life Sciences

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Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms

Received: 11 November 2014    Accepted: 25 November 2014    Published: 06 January 2015
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Abstract

This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.

DOI 10.11648/j.ajls.20140206.22
Published in American Journal of Life Sciences (Volume 2, Issue 6, December 2014)
Page(s) 406-412
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Zinc Acetate, Gastrointestinal Propulsion, Serotonergic Receptors and Transit Time

References
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Author Information
  • Department of Physiological Sciences/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria

  • Department of Physiological Sciences/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria

  • Department of Medical Pharmacology and Therapeutics/Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun-State Nigeria

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    Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. (2015). Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. American Journal of Life Sciences, 2(6), 406-412. https://doi.org/10.11648/j.ajls.20140206.22

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    Rufus Ojo Akomolafe; Olusoji Adeola Adalumo; Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am. J. Life Sci. 2015, 2(6), 406-412. doi: 10.11648/j.ajls.20140206.22

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    AMA Style

    Rufus Ojo Akomolafe, Olusoji Adeola Adalumo, Kayode Dominion Samuel Bamitale. Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms. Am J Life Sci. 2015;2(6):406-412. doi: 10.11648/j.ajls.20140206.22

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  • @article{10.11648/j.ajls.20140206.22,
      author = {Rufus Ojo Akomolafe and Olusoji Adeola Adalumo and Kayode Dominion Samuel Bamitale},
      title = {Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms},
      journal = {American Journal of Life Sciences},
      volume = {2},
      number = {6},
      pages = {406-412},
      doi = {10.11648/j.ajls.20140206.22},
      url = {https://doi.org/10.11648/j.ajls.20140206.22},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.20140206.22},
      abstract = {This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Attenuation of Gastrointestinal Tract Propulsion in Rats by Zinc Acetate: Investigation into Serotonergic and Dopaminergic Mechanisms
    AU  - Rufus Ojo Akomolafe
    AU  - Olusoji Adeola Adalumo
    AU  - Kayode Dominion Samuel Bamitale
    Y1  - 2015/01/06
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20140206.22
    DO  - 10.11648/j.ajls.20140206.22
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 406
    EP  - 412
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20140206.22
    AB  - This study evaluated the influence of orally administered zinc acetate on gastrointestinal tract propulsion of rats. It also evaluated the effects of the salt on faecal output and gastrointestinal transit time in the rats. The effects of zinc acetate on feeding as well as water intake were determined. The dose of zinc acetate which produced the maximal effect was used to investigate the receptors involved in the alteration of gastrointestinal motility by the salts. All the three doses of zinc acetate (50 mg/kg, 80 mg/kg and 110 mg/kg) produced a significant reduction in the number of total faecal pellets produced in eight hours of study (2.67 ± 0.67, 10.75 ± 0.60, 5 ± 0.52) respectively when compared with the control group (15.67 ± 0.52). Also, the three doses of zinc acetate produced a dose-dependent significant reduction in the faecal mass (1.23 ± 0.08g, 0.96 ± 0.07g, 0.59 ± 0.07g) respectively when compared with control group (3.39 ± 0.25g).The total transit time in rats treated with 50 mg/kg of zinc acetate (746.2 ± 5.95 minutes) increased significantly compared to the control group (251.2 ± 5.48 minutes). The three doses of zinc acetate produced a dose-dependent reduction (p < 0.05) in food intake (9.67 ± 0.61, 9.17 ± 0.62 and 5.00 ± 0.39) respectively compared to the control group (18.33 ± 0.67). Pre-treatment with metoclopramide (5HT3 & D2 blocker/5HT4 serotonergic agonist) significantly increased faecal pellet output in zinc acetate treated rats (4.80 ± 0.20) when compared with rats treated with zinc acetate alone (2.67 ± 0.67).The study concluded that zinc acetate reduced gastrointestinal tract propulsion in rats evidenced as increased intestinal transit time of rats and reduced faecal pellet output via stimulation of 5HT3 and 5HT4 serotonergic and dopaminergic receptors.
    VL  - 2
    IS  - 6
    ER  - 

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