Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism
American Journal of Life Sciences
Volume 3, Issue 1, February 2015, Pages: 1-5
Received: Nov. 24, 2014;
Accepted: Dec. 9, 2014;
Published: Jan. 14, 2015
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Udobi Chinweizu Ejikeme, Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
Daniel Mbuotidem David, Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.
Udobi Chinweizu Ejikeme,
Daniel Mbuotidem David,
Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism, American Journal of Life Sciences.
Vol. 3, No. 1,
2015, pp. 1-5.
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