Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism
American Journal of Life Sciences
Volume 3, Issue 1, February 2015, Pages: 1-5
Received: Nov. 24, 2014;
Accepted: Dec. 9, 2014;
Published: Jan. 14, 2015
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Udobi Chinweizu Ejikeme, Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
Daniel Mbuotidem David, Pharmaceutical Microbiology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
The continuous development of resistance by microorganisms to antibiotics has necessitated the use of combinations of agents for their containment. This has led to the combination of plant products or parts known to have potentials to control microorganisms with antibiotics without any scientific basis by traditional medicine practitioners. Erythromycin and Streptomycin were differently combined with concentrations of Blighia sapida previously known to control Staphylococcus aureus in anticipation of a synergistic or at least additive effect using both the Agar well diffusion method and strip - agar methods. Results obtained showed an undesirable antagonistic effect leading to a complete loss of activity in the case of Erythromycin against Escherichia coli and reduction in activity of streptomycin against both Escherichia coli and Pseudomonas aeruginosa. Plant product-antibiotic combinations in anticipation of synergism should not be done without scientific proof.
Udobi Chinweizu Ejikeme,
Daniel Mbuotidem David,
Plant Product- Drug Interaction: The Case of Blighia sapida Stem Bark Extract and Streptomycin or Erythromycin is Antagonism, American Journal of Life Sciences.
Vol. 3, No. 1,
2015, pp. 1-5.
Marquez, B. (2005): Bacterial efflux systems and efflux pump inhibitors. Biochimie. 87(12): 1137-1147.
Smith, E. C. J., Williamson, E. M., Wareham, N., Kaatz, G. N, Gibbons, S. (2007) Antibacterials and modulators of bacterial resistance from the immature cones of chamacyparis lawsoniana. Phytochem. 68(2) 210-217.
Gibbons, S. (2004). Anti-Staphylococcal plant natural products. Nat. Prod. Rep. 21: 263-277
Steve B. (2004). Herbal Property Dictionary. Lifelong Press
Udobi, Chinweizu Ejikeme. (2008). Antibacterial activities and phytochemical analysis of the Leaf, Stem bark and root of the African Locust Bean (Parkia biglobosa) (Jacq) Benth (Mimosaceae). PhD. Dissertation. Ahmadu Bello University, Zaria.
Lewis, K. Ausubel, F. M. (2006). Prospects for plant derived antibacterials. Nat. Biotechnol. 24(12): 1504-1507.
Nwozo S. O, Iwuoha E. I., Waryo T and Kgarebe B (2014). Isolation, Partial purification and characterization of antifungal trypsin inhibitor protease from the seed of Blighia sapida K. D Koenig (Ackee). Afri. Journ. Biotech. 13 (29) 2996-3007.
Esuoso KO, Odetoun SM. Proximate chemical composition and possibleindustrial utilization of B. sapida seed and oils. Journal of Phytotherapy Research 2005; 72(7):311–313.
John-Dewole, O. O. and Popoola, O. O. (2013). Chemical, Phytochemical and Antimicrobial Screening of Extracts of B. sapida for Agricultural and Medicinal Relevance. Nature and science, vol. 11(I10) 12-17
Veronica M. Dossou, Jacob K. Agbenorhevi, Sussana combey, Sarah Afi-Koryoe (2014). Ackee (Bilghia sapida) fruit arils: Nutritional, phytochemicals and antioxidant properties. Int. Journ. Nut. Food Sci. 3 (6) 534-537
Trease, E. G and Evans, W.C. (2006). Pharmacognosy 15th Ed. Elsevier Limited. 3-5
Sofowora, A. (1982). Medicinal plants and Traditional Medicine in Africa. John Wiley and sons Ltd. N. Y. 97 – 105, 142 – 146.
Baron, J. E., & Fingold, S. M. (1990). Methods for testing antimicrobial effectiveness. In: Bailey Scotts Diagnostic Microbiology. Mosby, C. V. (ed.) Missouri. 171- 194.
Zhao,W.H., Hu, Z.O. Okubo, S, Hara, Y., shimanura, T. (2001). Mechanism of synergy between Epigallocatechin gallate and lactams against methicillin resistant staphylococcus aureus. Antimicrobial. Agents chemother. 45(6): 1737 – 1742
Ubulom, P. M; Udobi, C. E; Akpabio, E. I; Eshiet, U. (2013). Antimicrobial activities of Leaf and Stem bark extracts of Blighia sapida Journal of Plant Studies; 2 ( 2) 47-52