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Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM
American Journal of Life Sciences
Volume 3, Issue 1, February 2015, Pages: 22-26
Received: Dec. 13, 2014; Accepted: Dec. 27, 2014; Published: Jan. 30, 2015
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Mohammed E. Al-Ghurabi, Department of biology, College of Science, University of Kufa, AL- najaf, Iraq
Ali A. Muhi, Department of biology, College of Science, University of Kufa, AL- najaf, Iraq
Dhefaf H. Al-Mudhafar, Department of biology, College of Science, University of Kufa, AL- najaf, Iraq
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Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.
To cite this article
Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar, Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM, American Journal of Life Sciences. Vol. 3, No. 1, 2015, pp. 22-26. doi: 10.11648/j.ajls.20150301.15
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