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Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM

Received: 13 December 2014    Accepted: 27 December 2014    Published: 30 January 2015
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Abstract

Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.

Published in American Journal of Life Sciences (Volume 3, Issue 1)
DOI 10.11648/j.ajls.20150301.15
Page(s) 22-26
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

ELAM-1, VCAM-1, NIDDM

References
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Cite This Article
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    Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. (2015). Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. American Journal of Life Sciences, 3(1), 22-26. https://doi.org/10.11648/j.ajls.20150301.15

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    ACS Style

    Mohammed E. Al-Ghurabi; Ali A. Muhi; Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am. J. Life Sci. 2015, 3(1), 22-26. doi: 10.11648/j.ajls.20150301.15

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    AMA Style

    Mohammed E. Al-Ghurabi, Ali A. Muhi, Dhefaf H. Al-Mudhafar. Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM. Am J Life Sci. 2015;3(1):22-26. doi: 10.11648/j.ajls.20150301.15

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  • @article{10.11648/j.ajls.20150301.15,
      author = {Mohammed E. Al-Ghurabi and Ali A. Muhi and Dhefaf H. Al-Mudhafar},
      title = {Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1},
      pages = {22-26},
      doi = {10.11648/j.ajls.20150301.15},
      url = {https://doi.org/10.11648/j.ajls.20150301.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150301.15},
      abstract = {Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result  revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Vascular Cell Adhesion Molecule-1 and Endothelial Leukocyte Adhesion Molecule-1 as Markers of Atherosclerosis of NIDDM
    AU  - Mohammed E. Al-Ghurabi
    AU  - Ali A. Muhi
    AU  - Dhefaf H. Al-Mudhafar
    Y1  - 2015/01/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150301.15
    DO  - 10.11648/j.ajls.20150301.15
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 22
    EP  - 26
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150301.15
    AB  - Background: Leukocyte adhesion to arterial endothelial cells is thought to be an important step in the development of atherosclerosis, Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) and the endothelial-leukocyte adhesion molecule-1 (ELAM-1) play an essential role in the early stages of atherogenesis of diabetic patients. Materials and Methods: The study was conducted on 80 male divided into two groups 60 of them had diabetes mellitus and 20 subjects were normal healthy individuals served as a control group. Enzyme linked immune sorbent assay (ELISA) was used for the measurement of serum VCAM-1and ELAM-1and WBC assay executed by automatic hematology analyzer the information of patients were obtained through a questionnaire consisted Patients with other diseases were excluded from the current investigation. Results: This result  revealed elevated level of serum VCAM-1and ELAM-1 of Diabetes patients compared with healthy group also differentiation count reveal elevated count of WBC, Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil in Diabetes patient as compare with HT group.
    VL  - 3
    IS  - 1
    ER  - 

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Author Information
  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

  • Department of biology, College of Science, University of Kufa, AL- najaf, Iraq

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