American Journal of Life Sciences

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Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice

Received: 25 January 2015    Accepted: 11 February 2015    Published: 16 February 2015
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Abstract

Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.

DOI 10.11648/j.ajls.20150302.12
Published in American Journal of Life Sciences (Volume 3, Issue 2, April 2015)
Page(s) 62-70
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Schistosoma Mansoni- Chloroform Extract of Citharexylum Quadrangular Leaves- Micronutrients

References
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Author Information
  • Therapeutic Chemistry Department, National Research Center, Dokki, Egypt

  • Therapeutic Chemistry Department, National Research Center, Dokki, Egypt; Biochemistry Department, Faculty of Science for Girl's, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

  • Zoology Department, Women's College for Arts, Science and Education, Ain Shams University, Cairo, Egypt

  • Therapeutic Chemistry Department, National Research Center, Dokki, Egypt; Biology Department, Faculty of Science for Girl's, Jazan University, Jazan, Kingdom of Saudi Arabia

  • Pathology Department, National Research Center, Dokki, Egypt

  • Therapeutic Chemistry Department, National Research Center, Dokki, Egypt

Cite This Article
  • APA Style

    Ebtehal M. Farrag, Azza M. Mohamed, Shadia M. Kadry, Ahlam H. Mahmoud, Abdel-Razik H. Farrag, et al. (2015). Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. American Journal of Life Sciences, 3(2), 62-70. https://doi.org/10.11648/j.ajls.20150302.12

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    ACS Style

    Ebtehal M. Farrag; Azza M. Mohamed; Shadia M. Kadry; Ahlam H. Mahmoud; Abdel-Razik H. Farrag, et al. Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. Am. J. Life Sci. 2015, 3(2), 62-70. doi: 10.11648/j.ajls.20150302.12

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    AMA Style

    Ebtehal M. Farrag, Azza M. Mohamed, Shadia M. Kadry, Ahlam H. Mahmoud, Abdel-Razik H. Farrag, et al. Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice. Am J Life Sci. 2015;3(2):62-70. doi: 10.11648/j.ajls.20150302.12

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  • @article{10.11648/j.ajls.20150302.12,
      author = {Ebtehal M. Farrag and Azza M. Mohamed and Shadia M. Kadry and Ahlam H. Mahmoud and Abdel-Razik H. Farrag and Dalia B. Fayed},
      title = {Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {2},
      pages = {62-70},
      doi = {10.11648/j.ajls.20150302.12},
      url = {https://doi.org/10.11648/j.ajls.20150302.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.20150302.12},
      abstract = {Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Impact of Citharexylum Quadrangular Chloroform Extract and Micronutrient on Praziquantel in Schistosoma Mansoni Infected Mice
    AU  - Ebtehal M. Farrag
    AU  - Azza M. Mohamed
    AU  - Shadia M. Kadry
    AU  - Ahlam H. Mahmoud
    AU  - Abdel-Razik H. Farrag
    AU  - Dalia B. Fayed
    Y1  - 2015/02/16
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150302.12
    DO  - 10.11648/j.ajls.20150302.12
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 62
    EP  - 70
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150302.12
    AB  - Praziquantel (PZQ), the drug of choice according to the World Health Organization (WHO), causes some side effects. The appearance of drug resistance against PZQ in Schistosoma mansoni infected species leads to must introduce new effective compounds and/or suppress its side effects. The aim of present work is a trial to solve this problem. Chloroform extract of Citharexylum quadrangular jacq leaves was used as a medicinal plant, which affect the Schistosoma mansoni adults. Prophylactic and therapeutic treatment of Schistosoma mansoni infected mice with the plant extract and/or the antioxidants vitamin E and selenium in combination with PZQ was studied. The study revealed that the combination of the chloroform extract together with vitamin E and selenium improved the efficiency of PZQ. These supplementations are very effective in ameliorating the oxidative insult as well as other parameters: glutathione reductase (GR), thioredoxin reductase (TrxR), catalase (CAT) and reduced glutathione (GSH), nitric oxide (NO) and lipid peroxidation (MDA), hepatic hydroxyproline content, Alanine aminotransferase (ALT), Gamma-glutamyltransferase (γ-GT), tumor necrosis factor-alpha (TNFα), interleukin- 10 (IL-10) and total immunoglobulin E (total IgE) associated with Schistosoma mansoni infection.
    VL  - 3
    IS  - 2
    ER  - 

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