American Journal of Life Sciences

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Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor

Received: 15 June 2015    Accepted: 11 July 2015    Published: 18 July 2015
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Abstract

Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.

DOI 10.11648/j.ajls.20150304.19
Published in American Journal of Life Sciences (Volume 3, Issue 4, August 2015)
Page(s) 311-315
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Intestinal Secretion, Barrier Function, mAChR, Inflammation

References
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Author Information
  • Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan; Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan

  • Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan

  • Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh; Department of Hematology & Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA

  • Department of Biochemistry, Asahikawa Medical University, Hokkaido, Japan

Cite This Article
  • APA Style

    Md. Rafiqul Islam Khan, Takashi Yazawa, Junsuke Uwada, Abu Syed Md. Anisuzzaman, Takanobu Taniguchi. (2015). Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. American Journal of Life Sciences, 3(4), 311-315. https://doi.org/10.11648/j.ajls.20150304.19

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    ACS Style

    Md. Rafiqul Islam Khan; Takashi Yazawa; Junsuke Uwada; Abu Syed Md. Anisuzzaman; Takanobu Taniguchi. Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. Am. J. Life Sci. 2015, 3(4), 311-315. doi: 10.11648/j.ajls.20150304.19

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    AMA Style

    Md. Rafiqul Islam Khan, Takashi Yazawa, Junsuke Uwada, Abu Syed Md. Anisuzzaman, Takanobu Taniguchi. Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor. Am J Life Sci. 2015;3(4):311-315. doi: 10.11648/j.ajls.20150304.19

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  • @article{10.11648/j.ajls.20150304.19,
      author = {Md. Rafiqul Islam Khan and Takashi Yazawa and Junsuke Uwada and Abu Syed Md. Anisuzzaman and Takanobu Taniguchi},
      title = {Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {4},
      pages = {311-315},
      doi = {10.11648/j.ajls.20150304.19},
      url = {https://doi.org/10.11648/j.ajls.20150304.19},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.20150304.19},
      abstract = {Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Intestinal Secretion and Barrier Function; Implication with Muscarinic Cholinoceptor
    AU  - Md. Rafiqul Islam Khan
    AU  - Takashi Yazawa
    AU  - Junsuke Uwada
    AU  - Abu Syed Md. Anisuzzaman
    AU  - Takanobu Taniguchi
    Y1  - 2015/07/18
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150304.19
    DO  - 10.11648/j.ajls.20150304.19
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 311
    EP  - 315
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150304.19
    AB  - Two most important physiological functions of intestinal epithelial cells (IECs) are intestinal secretion and barrier function in order to protect the host from invasive microorganisms. Acetylcholine (ACh) is regarded as a central molecule for the regulation of these gut functions. Although, ACh is considered as a classical neurotransmitter, numerous studies report the synthesis and release of ACh from non-neuronal epithelial cells and are believed to regulate gut functions via cholinergic activation. Recently, it is established that IECs express M1 and M3 muscarinic acetylcholine receptors (mAChRs). Although, the role of M3 mAChR-mediated intestinal secretion in Ussing Chamber has been highly established, little is known about M1 mAChR-mediated intestinal secretion and barrier function. Here, we review the current knowledge about the functions of M1 and M3 mAChRs and their downstream signaling in the regulation of intestinal secretion and barrier function. We also discuss the role of mAChRs in IECs under inflammatory conditions.
    VL  - 3
    IS  - 4
    ER  - 

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