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Antioxidant and Antidiabetic Properties of Vitex nigundo L. Leaves
American Journal of Life Sciences
Volume 5, Issue 1, February 2017, Pages: 21-26
Received: Dec. 25, 2016; Accepted: Jan. 10, 2017; Published: Mar. 6, 2017
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Most. Fatimatuz Zahura Falguni, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Amirul Islam, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Mahmudul Hasan, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
S. M. M. Mahmud Hossain Mousum, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
Md. Ashraduzzaman, Department of Chemistry, Rajshahi University of Engineering and Technology, Rajshahi, Bangladesh
Shahanaz Khatun, Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh
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Vitex Nigundo Linn. is credited with important medicinal activities such as antioxidant, anti-inflammatory, analgesic, anticonvulsant etc. The purpose of the presents study was to assess the therapy effect of V. Nigundo leaves extract on glucose level, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, SGPT and SGOT in blood serum of diabetic animals. Ethyl alcohol extract of V. Nigundo leaves in doses of 200 and 300 mgkg-1 body weights was daily administered orally by gavages to mice for 21 days to evaluate their antihyperglycemic and antihyperlipidemic effects on normal and streptozotocin-induced diabetic mice. Ethyl alcohol extract of V. Nigundo leaves in doses of 300 mgkg-1 body weights showed (P<0.01) more significant activity than the ethyl alcohol extract of V. Nigundo leaves in doses of 200 mgkg-1 body weights. The study validates scientifically the widely claimed use of V. Nigundo leaves as an ethnomedicine to treat diabetes mellitus.
Vitex nigundo, Antidiabetic, Diabetes Mellitus, Hyperglycemic, Hyperlipidemic
To cite this article
Most. Fatimatuz Zahura Falguni, Md. Amirul Islam, Md. Mahmudul Hasan, S. M. M. Mahmud Hossain Mousum, Md. Ashraduzzaman, Shahanaz Khatun, Antioxidant and Antidiabetic Properties of Vitex nigundo L. Leaves, American Journal of Life Sciences. Vol. 5, No. 1, 2017, pp. 21-26. doi: 10.11648/j.ajls.20170501.14
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
WHO, 2011. Diabetes. Downloaded from on 11 Jan 2011.
Birdee, G. S.; Yeh, G. Complementary and alternative medicine therapies for diabetes: a clinical review. Clinical Diabetes 2010, 28, 147-155.
Maiti, R.; Jana, D.; Das, U. K.; Ghosh, D. Antidiabetic effect of aqueous extract of seed of Tamarindusindicain streptozotocin-induced diabetic mices. Journal of Ethnopharmacology 2004, 92, 85-91.
Al-Shamaony, L.; Al-Khazraji, S. M.; Twaij, H. A. A. Hypoglycemic effect of Artemisia herbaalba. II. Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology 1994, 43, 167-171.
Jaiswal, D.; Rai, P. K.; Kumar, A. Mehta, S.; Watal, G. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic mices. Journal of Ethnopharmacology 2009, 123, 392-396.
"Vitex negundo L.". Germplasm Resources Information Network (GRIN). Retrieved September 7, 2011.
Dharmasiri, M. G.; Jayakody, J. R. A. C.; Galhena, G.; Liyanage, S. S. P.; Micenasooriya, W. D. Anti-inflammatory and analgesic activities of mature fresh leaves of Vitex negundo. Journal of Ethnopharmacology, 2003, 87 (2–3), 199–206
Sathiamoorthy, B.; Gupta, P.; Kumar, M.; Ashok K.; Chaturvedi, P. K. S.; Maurya, R. New antifungal flavonoid glycoside from Vitex negundo. Bioorganic & Medicinal Chemistry Letters 2007, 17 (1), 239–242.
Vitexnegundo L. in Dr. K. M. Madkarni’s Indian material medica: edited by A. K. Nadkarni, popular prakashani, Bombay: 1976: 1278-1280.
Tandon and Gupta. Effect of Vitex negundo on oxidative stresss. Indian Journal of Pharmacol., 2004, 36 (3), 176-177.
Soriful, I.; Mauluda, A.; Sarwar, P.; Jahangir, A; Firoz, M. A. Antitumor and Antibacterial Activity of a Crude Methanol Leaf Extract of Vitex negundo L. Archives of Biological Sciences 2013, 65, 229-238.
Chitra, V.; Sharma, S.; Kayande, N. Evaluation of Anticancer Activity of Vitex negundo in Experimental Animals: An in Vitro and in Vivo Study. International Journal of Pharm Tech Research 2009, 1, 1485-1489.
Roy Chowdhury, A.; Sharma, S.; Mandal, S.; Goswami, A.; Mukhopadhyay, S.; Majumder, H. K. Luteolin, an Emerging Anti-Cancer Flavonoid Poisons Eukaryotic DNA Topoisomerase-I. Biochemical Journal 2002, 366, 653-661.
Prasanna Raja P.; Sivakumar, V.; Riyazullah. M. S. Antidiabetic potential oaqueous and ethanol leaf extracts of Vitexnegundo. International journal of pharmacognosy and phytochemical research 2012, 4 (2), 38-40.
Pankaj, M.; Abhishek, S.; Vikas, S. Phytochemical Investigation and Hypoglycemic effects of Vitex negundo. Research and Reviews: Journal of Pharmacology and Toxicological Studies 2013, 1 (2), 22-26.
Shafiqul, I.; Samima, N.; Muhammad, A. K.; Sakhawat H; Farhadul, I; Proma, K; Nurul, H. M.; Mamunur, R.; Golam, S.; Aziz, A. R.; Khurshid, A. Evaluation of antioxidant and anticancer properties of the seed extracts of Syzygium fruticosum Roxb. growing in Rajshahi, Bangladesh, Islam et al. BMC Complementary and Alternative Medicine 2013, 13, 142.
Atanassova, M.; Georgieva, S.; Ivancheva, K. Total phenolic and total flavonoid contents, antioxidant capacity and biological contaminants in medicinal herbs. Journal of the University of Chemical Technology and Metallurgy 2011; 46 (1), 81-88.
Saravanan, R; Pari, L. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. BMC Complementary and Alternative Medicine 2005, 5, 14. doi: 10.1186/1472-6882-5-14.
Mallick, C; Maiti, R; Ghosh, D; Comparative study on antihyperglycemic and antihyperlipidemic effects of separate and composite extract of seed of Eugenia jambolana and root of Musa paradisiaca in streptozotocin-induced diabetic male albino rat. Iran J Pharmacol Ther 2006, 5, 27-33.
Rahman, M. S.; Asaduzzaman, M.; Munira, S.; Hasan, N.; Rahman, M. M.; Hasan, M.; Begum, M. M.; Maniruzzaman, M.; Islam, M. .; Khan, M. M. H.; Rahman, M.; Karim, M. R.; Islam, M. A. Effects of Coccinia cordifolia leaves extract on hepatic and cardiovascular disease matker in streptozotocin induced diabetic albino rats. International Journal Of Pharmacy & Technology 2015, 7 (2), 9178-9189.
Bhooshan, K.; Pandey; Syed, R. I. Plant polyphenols as dietary antioxidants in human. health and disease 2009, 2 (5), 270–278.
Tunali, S.; Yanardag, R.; Effect of vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissues of streptozotocin-induced diabetic rats. Pharmacol Res 2006; 53, 271-277.
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