The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis

Rongqin Dai; Yuzhi Liu; Jinbiao Zhang

doi:doi:10.11648/j.ajls.20200802.11

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The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis

Rongqin Dai, Yuzhi Liu, Jinbiao Zhang

Received: 27 May 2020 Accepted: Published: 22 July 2020

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Abstract

Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P<0.05). However, the difference between Hashimoto hyperthyroidism group and Hashimoto hypothyroidism group has no statistical significance (P>0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.

DOI	10.11648/j.ajls.20200802.11
Published in	American Journal of Life Sciences (Volume 8, Issue 2, April 2020)
Page(s)	19-22
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hashimoto's Thyroiditis, Thyroid Function, Antibody, Cytokine

References

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[3]	Chong Xianjin, Yu Qingyuan, Aman Guli•Suli Tang, et al. The effect of dexamethasone combined with thyroxine in the treatment of autoimmune thyroiditis and its effect on the related serum cytokines and Th1/Th2 related cytokines [J]. Chinese Journal of Difficult and Complicated Cases, 2018, 17 (11): 1233-1237.
[4]	Ma Ling, Chen Yuqiong, Du Juan, et al. Correlations between thyroid autoantibodies and thyroid function in patients with newly-diagnosed Hashimoto's thyroiditis [J]. China Journal of Modern Medicine, 2018, 28 (17): 94-97.
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[15]	Guo Y, Zynat J, Xing S, et al. Immunological changes of T helper cells in flow cytometersorted CD4 (+) T cells from patients with Hashimoto’s thyroiditis [J]. Exp Ther Med, 2018, 15 (4): 3596-3602.
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APA Style

Rongqin Dai, Yuzhi Liu, Jinbiao Zhang. (2020). The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. American Journal of Life Sciences, 8(2), 19-22. https://doi.org/10.11648/j.ajls.20200802.11

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ACS Style

Rongqin Dai; Yuzhi Liu; Jinbiao Zhang. The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. Am. J. Life Sci. 2020, 8(2), 19-22. doi: 10.11648/j.ajls.20200802.11

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AMA Style

Rongqin Dai, Yuzhi Liu, Jinbiao Zhang. The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. Am J Life Sci. 2020;8(2):19-22. doi: 10.11648/j.ajls.20200802.11

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@article{10.11648/j.ajls.20200802.11,
  author = {Rongqin Dai and Yuzhi Liu and Jinbiao Zhang},
  title = {The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis},
  journal = {American Journal of Life Sciences},
  volume = {8},
  number = {2},
  pages = {19-22},
  doi = {10.11648/j.ajls.20200802.11},
  url = {https://doi.org/10.11648/j.ajls.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20200802.11},
  abstract = {Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.},
 year = {2020}
}

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TY  - JOUR
T1  - The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis
AU  - Rongqin Dai
AU  - Yuzhi Liu
AU  - Jinbiao Zhang
Y1  - 2020/07/22
PY  - 2020
N1  - https://doi.org/10.11648/j.ajls.20200802.11
DO  - 10.11648/j.ajls.20200802.11
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 19
EP  - 22
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20200802.11
AB  - Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.
VL  - 8
IS  - 2
ER  -

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Author Information

Rongqin Dai

Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou, China
Yuzhi Liu

Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou, China
Jinbiao Zhang

Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China

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APA Style

Rongqin Dai, Yuzhi Liu, Jinbiao Zhang. (2020). The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. American Journal of Life Sciences, 8(2), 19-22. https://doi.org/10.11648/j.ajls.20200802.11

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ACS Style

Rongqin Dai; Yuzhi Liu; Jinbiao Zhang. The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. Am. J. Life Sci. 2020, 8(2), 19-22. doi: 10.11648/j.ajls.20200802.11

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AMA Style

Rongqin Dai, Yuzhi Liu, Jinbiao Zhang. The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis. Am J Life Sci. 2020;8(2):19-22. doi: 10.11648/j.ajls.20200802.11

Copy | Download

@article{10.11648/j.ajls.20200802.11,
  author = {Rongqin Dai and Yuzhi Liu and Jinbiao Zhang},
  title = {The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis},
  journal = {American Journal of Life Sciences},
  volume = {8},
  number = {2},
  pages = {19-22},
  doi = {10.11648/j.ajls.20200802.11},
  url = {https://doi.org/10.11648/j.ajls.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20200802.11},
  abstract = {Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis
AU  - Rongqin Dai
AU  - Yuzhi Liu
AU  - Jinbiao Zhang
Y1  - 2020/07/22
PY  - 2020
N1  - https://doi.org/10.11648/j.ajls.20200802.11
DO  - 10.11648/j.ajls.20200802.11
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 19
EP  - 22
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20200802.11
AB  - Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.
VL  - 8
IS  - 2
ER  -

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