American Journal of Life Sciences

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The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity

Received: 20 November 2014    Accepted: 25 November 2014    Published: 29 November 2014
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Abstract

Reactions to gamma-irradiation in an acute dose of 750 R in C57BL/6, 101/Hf and С3H/Sn mice at different physiological levels were analyzed. In C3H/Sn and 101/Hf mice, light scattering spectrum was shifted towards small particles, while in C57BL/6 mice increased contribution of large particles was observed. In 3 weeks, a shift towards larger particles was recorded in all three mouse strains, but its degree varied. By week 6, the histograms approached the control. Histological study showed that the incidence of severe injuries in the liver increased by the end of the experiment in C57BL/6 mice (but not in other mouse strains). The same shifts were observed in the pancreas and an opposite tendency was seen in the spleen. Thus, C57BL/6 mice responded to irradiation later that C3H/Sn and 101/Hf mice, but demonstrated high adaptation capacity. C3H/Sn mice best of all recovered from the radiation crisis.

DOI 10.11648/j.ajls.s.2015030102.13
Published in American Journal of Life Sciences (Volume 3, Issue 1-2, January 2015)

This article belongs to the Special Issue Space Flight Factors: From Cell to Body

Page(s) 13-17
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Irradiation, Strain-Specific Differences, Laser Correlation Spectroscopy, Radiosensitivity

References
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[2] Poletaeva I.I., Lil'p I.G., Irisova O.A., Ivanov V.I., BizikoevaF.Z., “An unusual type of locomotion in mice of line 101/Hy,” Genetika,vol.28, 12, 1992, pp.147-149 (in Russian).
[3] Karganov M., Alchinova I., Arkhipova E., Skalny A., “Laser Correlation Spectroscopy: Nutritional, Ecological and Toxic Aspects,” In: “Biophysics”. A.N. Misra ed.-InTech, 2012, ISBN 978-953-51-0376-9,pp.1-16.
[4] AlchinovaI., Arkhipova E., Medvedeva Yu., Cherepov A., Antipov A., Lysenko N., Noskin L., Karganov M., "The complex of tests for the quantitative evaluation of the effects of radiation on laboratory animals," – this issue, pp. 5-12.
[5] Karganov M., Shenkman B., Sychev V., Arkhipova E., Medvedeva U., Alchinova I., “Differentiation of changes in serum homeostasis of laboratory animals after exposure on a BION-M1 satellite,” Abs. of 40th Scientific Assembly “COSPAR Moscow 2014”,2-10 Aug. 2014, Moscow.
[6] Williams J. P., McBride W.H., “After the bomb drops: A new look at radiation-induced multiple organ dysfunction syndrome (MODS),” Int .J. Radiat. Biol., vol. 87, No 8,2011, pp. 851–868.
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[9] Karganov M., Skalny A.,AlchinovaI., Khlebnikova N., Grabeklis A., Lakarova E., Eisazadeh S., “Combined use of laser correlation spectroscopy and ICP-AES, ICP-MS determination of macro- and trace elements in human biosubstrates for intoxication risk assessment,” Trace elements and electrolytes, vol.28, No.2, 2011, pp.124-127.
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Author Information
  • Institute of General Pathology and Pathophysiology, Moscow, Russia

  • Institute of General Pathology and Pathophysiology, Moscow, Russia

  • Institute of General Pathology and Pathophysiology, Moscow, Russia

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    Yulia Medvedeva, Elena Arkhipova, Irina Alchinova. (2014). The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity. American Journal of Life Sciences, 3(1-2), 13-17. https://doi.org/10.11648/j.ajls.s.2015030102.13

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    Yulia Medvedeva; Elena Arkhipova; Irina Alchinova. The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity. Am. J. Life Sci. 2014, 3(1-2), 13-17. doi: 10.11648/j.ajls.s.2015030102.13

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    Yulia Medvedeva, Elena Arkhipova, Irina Alchinova. The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity. Am J Life Sci. 2014;3(1-2):13-17. doi: 10.11648/j.ajls.s.2015030102.13

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  • @article{10.11648/j.ajls.s.2015030102.13,
      author = {Yulia Medvedeva and Elena Arkhipova and Irina Alchinova},
      title = {The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {1-2},
      pages = {13-17},
      doi = {10.11648/j.ajls.s.2015030102.13},
      url = {https://doi.org/10.11648/j.ajls.s.2015030102.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.s.2015030102.13},
      abstract = {Reactions to gamma-irradiation in an acute dose of 750 R in C57BL/6, 101/Hf and С3H/Sn mice at different physiological levels were analyzed. In C3H/Sn and 101/Hf mice, light scattering spectrum was shifted towards small particles, while in C57BL/6 mice increased contribution of large particles was observed. In 3 weeks, a shift towards larger particles was recorded in all three mouse strains, but its degree varied. By week 6, the histograms approached the control. Histological study showed that the incidence of severe injuries in the liver increased by the end of the experiment in C57BL/6 mice (but not in other mouse strains). The same shifts were observed in the pancreas and an opposite tendency was seen in the spleen. Thus, C57BL/6 mice responded to irradiation later that C3H/Sn and 101/Hf mice, but demonstrated high adaptation capacity. C3H/Sn mice best of all recovered from the radiation crisis.},
     year = {2014}
    }
    

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    T1  - The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity
    AU  - Yulia Medvedeva
    AU  - Elena Arkhipova
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    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
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    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.s.2015030102.13
    AB  - Reactions to gamma-irradiation in an acute dose of 750 R in C57BL/6, 101/Hf and С3H/Sn mice at different physiological levels were analyzed. In C3H/Sn and 101/Hf mice, light scattering spectrum was shifted towards small particles, while in C57BL/6 mice increased contribution of large particles was observed. In 3 weeks, a shift towards larger particles was recorded in all three mouse strains, but its degree varied. By week 6, the histograms approached the control. Histological study showed that the incidence of severe injuries in the liver increased by the end of the experiment in C57BL/6 mice (but not in other mouse strains). The same shifts were observed in the pancreas and an opposite tendency was seen in the spleen. Thus, C57BL/6 mice responded to irradiation later that C3H/Sn and 101/Hf mice, but demonstrated high adaptation capacity. C3H/Sn mice best of all recovered from the radiation crisis.
    VL  - 3
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