The Association of Meat Consumption and Breast Cancer Risk: A Case Control Study in a Population of Iranian Women
American Journal of Life Sciences
Volume 3, Issue 2-1, March 2015, Pages: 6-11
Received: Nov. 12, 2014;
Accepted: Nov. 14, 2014;
Published: Nov. 22, 2014
Views 3112 Downloads 148
Zeinab Karimi, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zahra Bahadoran, Nutrition and Endocrine Research Center, and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Anahita Houshiar-rad, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hamid-Reza Mirzayi, Department of Radiation Oncology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bahram Rashidkhani, Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Objective: Epidemiologic data do not provide consistent evidence for an association between consumption of meat and breast cancer risk. We conducted a hospital-based case-control study during April and July 2010 among Iranian women to investigate associations between dietary meat intake, its types and breast cancer risk. Methods: One-hundred consecutively recruited cases with newly diagnosed breast cancer were frequency matched to 175 controls by age. Dietary intake was assessed by using a validated semi-quantitative food frequency questionnaire. Odds ratios and 95% confidence interval were obtained by using multiple logistic regression models adjusted for various potentially confounding variables. Results: The mean age of participant was 46.2±8.9 and 45.9±9.4 y in cases and controls, respectively. After adjustment of potential confounders, no association was found between total meat intake and the odds of breast cancer, but the risk of breast cancer in the forth quartile of red meat intake, compared with first quartile, significantly increased (OR=2.43, 95% CI=1.11-5.32). Consumption of poultry > 212 g/week significantly decreased the risk of breast cancer. Higher intake of fish meat decreased the odds of breast cancer (P for trend<0.05), whereas higher intake of processed meat was accompanied with increased the risk of breast cancer (P for trend<0.05). Conclusion: We found a positive association between dietary intake of red meat and processed meat products with the odds of breast cancer, as well as protective effects of fish and poultry intake with breast cancer.
The Association of Meat Consumption and Breast Cancer Risk: A Case Control Study in a Population of Iranian Women, American Journal of Life Sciences. Special Issue:Nutrition and Cancer.
Vol. 3, No. 2-1,
2015, pp. 6-11.
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60(5):277-300.
Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide IARC Cancer Base No 5  Lyon, France: IARC; 2001.
Bray F, McCarron P, Parkin DM. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res 2004; 6(6):229-39.
Mousavi SM, Montazeri A, Mohagheghi MA, Jarrahi AM, Harirchi I, Najafi M, et al. Breast cancer in Iran: an epidemiological review. Breast J 2007; 13(4):383-91.
Mettlin C. Breast cancer risk factors. Contributions to planning breast cancer control. Cancer 1992; 69(7 Suppl):1904-10.
Gross RE. Breast cancer: risk factors, screening, and prevention. Semin Oncol Nurs 2000; 16(3):176-84.
Lee SM, Park JH, Park HJ. Breast cancer risk factors in Korean women: a literature review. Int Nurs Rev 2008; 55(3):355-9.
Holmes MD, Willett WC. Does diet affect breast cancer risk? Breast Cancer Res 2006; 6(4):170-8.
Michels KB, Mohllajee AP, Roset-Bahmanyar E, Beehler GP, Moysich KB. Diet and breast cancer: a review of the prospective observational studies. Cancer 2007; 109 (12 Suppl): 2712-49.
Linos E, Willett WC, Cho E, Colditz G, Frazier LA. Red meat consumption during adolescence among premenopausal women and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 2008; 17(8):2146-51.
Alexander DD, Morimoto LM, Mink PJ, Cushing CA. A review and meta-analysis of red and processed meat consumption and breast cancer. Nutr Res Rev 2010; 23(2):349-65.
Delfino RJ, Sinha R, Smith C, West J, White E, Lin HJ, Liao SY, Gim JS, Ma HL, Butler J, Anton-Culver H. Breast cancer, heterocyclic aromatic amines from meat and N-acetyltransferase 2 genotype. Carcinogenesis 2000; 21(4):607-15.
Zhang CX, Ho SC, Chen YM, Lin FY, Fu JH, Cheng SZ. Meat and egg consumption and risk of breast cancer among Chinese women. Cancer Causes Control 2009; 20(10):1845-53.
Holmes MD, Colditz GA, Hunter DJ, Hankinson SE, Rosner B, Speizer FE, Willett WC. Meat, fish and egg intake and risk of breast cancer. Int J Cancer 2003; 104(2):221-7.
Pala V, Krogh V, Berrino F, Sieri S, Grioni S, Tjønneland A, et al. Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr 2009; 90(3):602-12.
Genkinger JM, Makambi KH, Palmer JR, Rosenberg L, Adams-Campbell LL. Consumption of dairy and meat in relation to breast cancer risk in the Black Women's Health Study. Cancer Causes Control 2013.
Larsson SC, Bergkvist L, Wolk A. Long-term meat intake and risk of breast cancer by oestrogen and progesterone receptor status in a cohort of Swedish women. Eur J Cancer 2009; 45(17):3042-6.
Kabat GC, Cross AJ, Park Y, Schatzkin A, Hollenbeck AR, Rohan TE, Sinha R. Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study. Int J Cancer 2009; 124(10):2430-5.
Cho E, Chen WY, Hunter DJ. Red meat intake and risk of breast cancer among premenopausal women. Arch Intern Med 2006; 166: 2253–9.
Taylor EF, Burley VJ, Greenwood DC, Cade JE. Meat consumption and risk of breast cancer in the UK Women's Cohort Study. Br J Cancer 2007; 96:1139–46.
Aune D, De Stefani E, Ronco A, Boffetta P, Deneo-Pellegrini H, Acosta G, et al. Meat consumption and cancer risk: a case-control study in Uruguay. Asian Pac J Cancer Prev 2009; 10(3):429-36.
Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ, Minkin S. Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer 2003; 89:1672–85.
Missmer SA, Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, et al. Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol 2002; 31(1):78-85.
Stripp C, Overvad K, Christensen J, Thomsen BL, Olsen A, Møller S, Tjønneland A. Fish intake is positively associated with breast cancer incidence rate. J Nutr 2003; 133(11):3664-9.
Fu Z, Deming SL, Fair AM, Shrubsole MJ, Wujcik DM, Shu XO, Kelley M, Zheng W. Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study. Breast Cancer Res Treat 2011; 129(3):919-28.
Lauber SN, Gooderham NJ. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells. Toxicology 2011; 279(1-3):139-45.
Wu K, Sinha R, Holmes MD, Giovannucci E, Willett W, Cho E. Meat mutagens and breast cancer in postmenopausal women--a cohort analysis. Cancer Epidemiol Biomarkers Prev 2010; 19(5):1301-10.
Linos E, Willett W. Meat, dairy, and breast cancer: do we have an answer? Am J Clin Nutr 2009; 90(3):455-6.