American Journal of Life Sciences

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Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease

Received: 29 March 2015    Accepted: 08 April 2015    Published: 06 May 2015
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Abstract

Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.

DOI 10.11648/j.ajls.s.2015030302.17
Published in American Journal of Life Sciences (Volume 3, Issue 3-2, May 2015)

This article belongs to the Special Issue Biology and Medicine of Peptide and Steroid Hormones

Page(s) 39-42
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Adrenomedullin, Inflammatory Bowel Disease, TNBS, DSS

References
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[5] Kitamura, K., Kangawa, K. Eto, T. Adrenomedullin and PAMP: discovery, structures, and cardiovascular functions. Microscopy research and technique 57, 3-13, doi:10.1002/jemt.10052 (2002).
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Author Information
  • Divivion of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

  • Divivion of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

  • Divivion of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

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  • APA Style

    Sayaka Nagata, Tomomi Hikosaka, Kazuo Kitamura. (2015). Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. American Journal of Life Sciences, 3(3-2), 39-42. https://doi.org/10.11648/j.ajls.s.2015030302.17

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    ACS Style

    Sayaka Nagata; Tomomi Hikosaka; Kazuo Kitamura. Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. Am. J. Life Sci. 2015, 3(3-2), 39-42. doi: 10.11648/j.ajls.s.2015030302.17

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    AMA Style

    Sayaka Nagata, Tomomi Hikosaka, Kazuo Kitamura. Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease. Am J Life Sci. 2015;3(3-2):39-42. doi: 10.11648/j.ajls.s.2015030302.17

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  • @article{10.11648/j.ajls.s.2015030302.17,
      author = {Sayaka Nagata and Tomomi Hikosaka and Kazuo Kitamura},
      title = {Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {3-2},
      pages = {39-42},
      doi = {10.11648/j.ajls.s.2015030302.17},
      url = {https://doi.org/10.11648/j.ajls.s.2015030302.17},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajls.s.2015030302.17},
      abstract = {Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.},
     year = {2015}
    }
    

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    T1  - Effect of Adrenomedullin Administration in Two Rat Models of Experimental Inflammatory Bowel Disease
    AU  - Sayaka Nagata
    AU  - Tomomi Hikosaka
    AU  - Kazuo Kitamura
    Y1  - 2015/05/06
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.s.2015030302.17
    DO  - 10.11648/j.ajls.s.2015030302.17
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 39
    EP  - 42
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.s.2015030302.17
    AB  - Adrenomedullin (AM) is a novel hypotensive peptide that also exerts powerful anti-inflammatory effects. We recently showed that AM significantly reduces the clinical severity of acetic acid-induced colitis, an experimental model of inflammatory bowel disease (IBD) in rats. In the present study, we examined the effect of AM in two alternative rat models of IBD. We found that 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced megacolon development in the saline-treated group, but AM treatment reduced the macroscopic damage caused by TNBS. In the dextran sulfate sodium (DSS) model, treatment with AM reduced diarrhea and bloody stool scores, but did not reduce body weight. Histological analysis revealed that in both the TNBS and DSS models, colon inflammation was much more severe in the saline-treated group than in the AM-treated group. These findings indicate that the anti-inflammatory properties of AM make it an effective therapeutic agent for the treatment of IBD in rats.
    VL  - 3
    IS  - 3-2
    ER  - 

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