The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity
American Journal of Life Sciences
Volume 3, Issue 1-2, January 2015, Pages: 13-17
Received: Nov. 20, 2014; Accepted: Nov. 25, 2014; Published: Nov. 29, 2014
Views 3194      Downloads 91
Authors
Yulia Medvedeva, Institute of General Pathology and Pathophysiology, Moscow, Russia
Elena Arkhipova, Institute of General Pathology and Pathophysiology, Moscow, Russia
Irina Alchinova, Institute of General Pathology and Pathophysiology, Moscow, Russia
Article Tools
Follow on us
Abstract
Reactions to gamma-irradiation in an acute dose of 750 R in C57BL/6, 101/Hf and С3H/Sn mice at different physiological levels were analyzed. In C3H/Sn and 101/Hf mice, light scattering spectrum was shifted towards small particles, while in C57BL/6 mice increased contribution of large particles was observed. In 3 weeks, a shift towards larger particles was recorded in all three mouse strains, but its degree varied. By week 6, the histograms approached the control. Histological study showed that the incidence of severe injuries in the liver increased by the end of the experiment in C57BL/6 mice (but not in other mouse strains). The same shifts were observed in the pancreas and an opposite tendency was seen in the spleen. Thus, C57BL/6 mice responded to irradiation later that C3H/Sn and 101/Hf mice, but demonstrated high adaptation capacity. C3H/Sn mice best of all recovered from the radiation crisis.
Keywords
Irradiation, Strain-Specific Differences, Laser Correlation Spectroscopy, Radiosensitivity
To cite this article
Yulia Medvedeva, Elena Arkhipova, Irina Alchinova, The Effects of Gamma-Irradiation in Sub-Lethal Doses in Mice with Different Radiosensitivity, American Journal of Life Sciences. Special Issue:Space Flight Factors: From Cell to Body. Vol. 3, No. 1-2, 2015, pp. 13-17. doi: 10.11648/j.ajls.s.2015030102.13
References
[1]
Takabatake T, Kakinuma S, Hirouchi T, Nakamura M, Fujikawa K, Nishimura M, Oghiso Y, Shimada Y, Tanaka K., “Analysis of changes in DNA copy number in radiation-induced thymic lymphomas of susceptible C57BL/6, resistant C3H and hybrid F1 Mice,”Radiat Res.,vol.169(4), 2008, pp .426-436. doi: 10.1667/RR1180.1.
[2]
Poletaeva I.I., Lil'p I.G., Irisova O.A., Ivanov V.I., BizikoevaF.Z., “An unusual type of locomotion in mice of line 101/Hy,” Genetika,vol.28, 12, 1992, pp.147-149 (in Russian).
[3]
Karganov M., Alchinova I., Arkhipova E., Skalny A., “Laser Correlation Spectroscopy: Nutritional, Ecological and Toxic Aspects,” In: “Biophysics”. A.N. Misra ed.-InTech, 2012, ISBN 978-953-51-0376-9,pp.1-16.
[4]
AlchinovaI., Arkhipova E., Medvedeva Yu., Cherepov A., Antipov A., Lysenko N., Noskin L., Karganov M., "The complex of tests for the quantitative evaluation of the effects of radiation on laboratory animals," – this issue, pp. 5-12.
[5]
Karganov M., Shenkman B., Sychev V., Arkhipova E., Medvedeva U., Alchinova I., “Differentiation of changes in serum homeostasis of laboratory animals after exposure on a BION-M1 satellite,” Abs. of 40th Scientific Assembly “COSPAR Moscow 2014”,2-10 Aug. 2014, Moscow.
[6]
Williams J. P., McBride W.H., “After the bomb drops: A new look at radiation-induced multiple organ dysfunction syndrome (MODS),” Int .J. Radiat. Biol., vol. 87, No 8,2011, pp. 851–868.
[7]
Mazurik V.K., Mikhaĭlov V.F.,“Radiation-induced genomic instability: phenomenon, molecular mechanisms, pathogenetic significance,”RadiatsBiolRadioecol., vol. 41, No.3, 2001, pp. 272-289(in Russian).
[8]
Van Waas M, Neggers SJ, Raat H, van Rij CM, Pieters R, Van den Heuvel-Eibrink MM., “Abdominal radiotherapy: a major determinant of metabolic syndrome in nephroblastoma and neuroblastoma survivors,”PLoS One, 2012, vol.7(12):e52237. doi: 10.1371/journal.pone.0052237
[9]
Karganov M., Skalny A.,AlchinovaI., Khlebnikova N., Grabeklis A., Lakarova E., Eisazadeh S., “Combined use of laser correlation spectroscopy and ICP-AES, ICP-MS determination of macro- and trace elements in human biosubstrates for intoxication risk assessment,” Trace elements and electrolytes, vol.28, No.2, 2011, pp.124-127.
[10]
Karganov M., Alchinova I., Malinovskaya E., Smirnova T.,Veiko N., “A new method for evaluation of the apoptotic process in cell by the size of particles in extracellular media,” In: “Apoptosis World 2008. From mechanisms to applications”. Luxembourg, 2008, pp.438.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186