The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis
American Journal of Life Sciences
Volume 8, Issue 2, April 2020, Pages: 19-22
Received: Jul. 20, 2020;
Published: Jul. 22, 2020
Views 120 Downloads 51
Rongqin Dai, Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou, China
Yuzhi Liu, Institute of Thyroid Disease Affiliated to Cangzhou Medical College, Cangzhou, China
Jinbiao Zhang, Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Objective: To assess the correlation of thyroid function and serum immunological indexes in patients with Hashimoto's thyroiditis. Method: To select 172 patients who have been clinically confirmed with HT. And they were divided into Hashimoto hyperthyroidism group within 39 cases, Hashimoto hypothyroidism group within 92 cases and normal Hashimoto's thyroid function group within 41 cases on the basis of Thyroid function. Besides, 50 healthy controls were control group. ECLIA was adopted to test the Thyroid function and antibody indicators of every group, and ELISA was employed to detect Th1 type cytokines (IL-2, IFN-γ) and Th2 type cytokines (IL-6, IL-10). Result: Every group with Hashimoto's thyroiditis was evidently higher than the normal one as well as the Hashimoto hypothyroidism group was higher than the Hashimoto hyperthyroidism group and the normal one in TPOAb and TGAb levels, in which the difference has statistical significance (P<0.05). However, the difference between Hashimoto hyperthyroidism group and Hashimoto hypothyroidism group has no statistical significance (P>0.05); Moreover, the IL-2, IFN-γ levels of the Hashimoto hyperthyroidism group and the normal Hashimoto's thyroid function group were distinctly higher than that of the Hashimoto hypothyroidism group; And the IL-6 and IL-10 levels were obviously higher than the Hashimoto hyperthyroidism group as well as the normal Hashimoto's thyroid function group (P<0.05). Besides, the TSH was positively correlated with the TPOAb and the IL-10. And FT4 was negatively correlated with the TPOAb, TGAb, IL-6. Not only the FT3 and TGAb but also the TT4 and IL-6 were in negative correlation. But the other indexes have no correlation. Conclusion: The patients with Hashimoto's thyroiditis have high TPOAb and TGAb levels. In addition, the TPOAb, TGAb and cytokines levels in the serum of HT patients with different thyroid function have evidently discrepancy, which may be closely related to the occurrence and development of the disease.
The Research on the Correlation of Thyroid Function and Serum Immunological Indexes in Patients with Hashimoto's Thyroiditis, American Journal of Life Sciences.
Vol. 8, No. 2,
2020, pp. 19-22.
Chen Yumin, Hu Fengqiu, Huang Hui, et al. The effect of Treg and Th17 cells in Hashimoto's thyroiditis patients with normal thyroid function [J]. Medical Journal of West China, 2018, 30 (10): 1438-1442.
GABALEC F, SRBOVA L, NOVA M, et al. Impact of Hashimoto's thyroiditis, TSH levels, and anti-thyroid antibody positivity on differentiated thyroid carcinoma incidence [J]. Endokrynol Pol, 2016, 67 (1): 48-53.
Chong Xianjin, Yu Qingyuan, Aman Guli•Suli Tang, et al. The effect of dexamethasone combined with thyroxine in the treatment of autoimmune thyroiditis and its effect on the related serum cytokines and Th1/Th2 related cytokines [J]. Chinese Journal of Difficult and Complicated Cases, 2018, 17 (11): 1233-1237.
Ma Ling, Chen Yuqiong, Du Juan, et al. Correlations between thyroid autoantibodies and thyroid function in patients with newly-diagnosed Hashimoto's thyroiditis [J]. China Journal of Modern Medicine, 2018, 28 (17): 94-97.
Ma Shifen, Wang Juanhong, Wei Wei, et al. Expression and its clinical significance of IL-4 and IL-6 in Hashimoto's thyroiditis [J]. Journal of Shanxi Medical University, 2018, 49 (12): 1483-1487.
Ge Junbo, Xu Yongjian. Internal Medicine [M]. 8th Edition. Beijing: People's Medical Publishing House, 2013: 698.
Liu Guanchang, Ma Shaoning. Biochemical examination [M]. 4th Edition. Beijing: People's Medical Publishing House, 2015: 316.
Jin Baosheng, Fan Wei, Qi Jinyou. Effect of Elevated Serum TPOAb and TgAb on thyroid disease progression [J]. International Journal of Laboratory Medicine, 2014, 35 (24): 3433-3436.
Song YH, Li Y, Maclaren NK. The nature of autoantigens targeted in autoimmune endocrine diseases [J]. Immunology Today. 1996, 17 (5): 232-238.
Liang Xiuzhen, Wang Jing, Yang Xiaoqiong, et al. Diagnostic value of thyroid autoantibodies in Hashimoto′s thyroiditis: a Meta analysis [J]. International Journal of Laboratory Medicine, 2018, 39 (10): 1206-1210.
Du Juan. The Relationship between Hashimoto’S thyroiditis and TCM syndrome type And association between thyroid autoantibodies and thyroid function in patients [D]. [Master's thesis]. Nanjing: Nanjing University of Chinese Medicine, 2017: 3.
Xiao Fang. Study on potential roles of NETs in the pathogenesis of Hashimoto’s thyroiditis and underlying mechanisms [D]. [Doctoral dissertation]. Jinan: Shandong University, 2018: 34.
Zhao Tingting. Correlation between Hashimoto’S thyroiditis with normal thyroid function and insulin resistance in patients with thyroid nodules [D]. [Master's thesis]. Dalian: Dalian Medical University, 2018: 9.
Jiang Yanping, Zhang Huili. Preliminary study of Th1 / Th2 Imbalance in Different Types of Autojmmune Thyroid Disease [J]. Journal of Medical Research, 2014, 43 (6): 111-114.
Guo Y, Zynat J, Xing S, et al. Immunological changes of T helper cells in flow cytometersorted CD4 (+) T cells from patients with Hashimoto’s thyroiditis [J]. Exp Ther Med, 2018, 15 (4): 3596-3602.
Mikos H, Mikos M, Obaramoszyńska M, et al. The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease (AITD) [J]. Endokrynol Pol, 2014, 65 (2): 150-155.
Inoue N, Watanabe M, Nakaguchi A, et al. Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases [J]. Endocrine Journal, 2017, 64 (7): 695-703.
Yu S, Sharp GC, Braley-Mullen H. Thyrocytes responding to IFN-gamma are essent ial for development of lymphocytic spontaneous autoimmune thyroiditi s and inhibition of thyrocyte hyperplasia [J]. J Immunol, 2006, 176 (2): 1259-1265.
Wang Lele, Chen Xiaopan. A study of MiRNA in autoimmune thyroid disease [J]. Journal of Hainan Medical University, 2018, 24 (21): 1939-1942.