Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)
American Journal of Life Sciences
Volume 1, Issue 3, June 2013, Pages: 130-135
Received: Jun. 4, 2013;
Published: Jun. 30, 2013
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Amani Nour El-Din Abd El-Latif, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt
Sahar Mohamed Elsheikh, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author); Oral Pathology, Faculty of Dentistry. Alexandria Egypt
Hashem Mohamed Hassouna, Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author); L Oral Maxillofacial surgery, Faculty of Dentistry, Pharos University in Alexandria, Egypt
Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.
Amani Nour El-Din Abd El-Latif,
Sahar Mohamed Elsheikh,
Hashem Mohamed Hassouna,
Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1), American Journal of Life Sciences.
Vol. 1, No. 3,
2013, pp. 130-135.
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