Agriculture, Forestry and Fisheries

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Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells

Received: 11 October 2017    Accepted: 26 October 2017    Published: 22 November 2017
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Abstract

Fatty liver disease is characterized by the accumulation of triglycerides and other fats in the liver cells and is believed to be a risk of later chronic liver disease. Diet is one of the key ways to treat fatty liver disease. Octopus (Enterocopus dofleini) liver is eaten in some regions in Japan, but mostly discarded. For utilization of octopus liver, the lipid-lowering effect of octopus (Enterocopus dofleini) liver extract was investigated using human hepatoma cells (HepG2 cells). The present study showed that the octopus liver extract reduced the triglyceride content, but not cholesterol content, in HepG2 cells. Treatment with the octopus liver extract increased the mRNA expression of genes for peroxisome proliferator-activated receptor (PPAR)-α, medium chain acyl-CoA dehydrogenase (MCAD), and acyl-CoA oxidase (ACO) associated with β-oxidation. On the contrary, the extract did not change the mRNA expression of genes for sterol regulatory element-binding protein (SREBP)-1, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD)-1, and peroxisome proliferator-activated receptor (PPAR)-γ involved in fatty acid synthesis. These results suggest that octopus liver extract may decrease the triglyceride level in HepG2 cells by promoting β-oxidation, suggestive of its usefulness as a food for lowering triglycerides in liver.

DOI 10.11648/j.aff.20170606.15
Published in Agriculture, Forestry and Fisheries (Volume 6, Issue 6, December 2017)
Page(s) 214-218
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Efficient Utilization, Octopus Liver Extract, HepG2 Cells, Triglyceride

References
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Author Information
  • Department of Applied Sciences, Muroran Institute of Technology, Hokkaido, Japan

  • Department of Applied Sciences, Muroran Institute of Technology, Hokkaido, Japan

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  • APA Style

    Yasushi Hasegawa, Tomohiko Hori. (2017). Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells. Agriculture, Forestry and Fisheries, 6(6), 214-218. https://doi.org/10.11648/j.aff.20170606.15

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    ACS Style

    Yasushi Hasegawa; Tomohiko Hori. Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells. Agric. For. Fish. 2017, 6(6), 214-218. doi: 10.11648/j.aff.20170606.15

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    AMA Style

    Yasushi Hasegawa, Tomohiko Hori. Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells. Agric For Fish. 2017;6(6):214-218. doi: 10.11648/j.aff.20170606.15

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  • @article{10.11648/j.aff.20170606.15,
      author = {Yasushi Hasegawa and Tomohiko Hori},
      title = {Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells},
      journal = {Agriculture, Forestry and Fisheries},
      volume = {6},
      number = {6},
      pages = {214-218},
      doi = {10.11648/j.aff.20170606.15},
      url = {https://doi.org/10.11648/j.aff.20170606.15},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.aff.20170606.15},
      abstract = {Fatty liver disease is characterized by the accumulation of triglycerides and other fats in the liver cells and is believed to be a risk of later chronic liver disease. Diet is one of the key ways to treat fatty liver disease. Octopus (Enterocopus dofleini) liver is eaten in some regions in Japan, but mostly discarded. For utilization of octopus liver, the lipid-lowering effect of octopus (Enterocopus dofleini) liver extract was investigated using human hepatoma cells (HepG2 cells). The present study showed that the octopus liver extract reduced the triglyceride content, but not cholesterol content, in HepG2 cells. Treatment with the octopus liver extract increased the mRNA expression of genes for peroxisome proliferator-activated receptor (PPAR)-α, medium chain acyl-CoA dehydrogenase (MCAD), and acyl-CoA oxidase (ACO) associated with β-oxidation. On the contrary, the extract did not change the mRNA expression of genes for sterol regulatory element-binding protein (SREBP)-1, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD)-1, and peroxisome proliferator-activated receptor (PPAR)-γ involved in fatty acid synthesis. These results suggest that octopus liver extract may decrease the triglyceride level in HepG2 cells by promoting β-oxidation, suggestive of its usefulness as a food for lowering triglycerides in liver.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Octopus (Enterocopus dofleini) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells
    AU  - Yasushi Hasegawa
    AU  - Tomohiko Hori
    Y1  - 2017/11/22
    PY  - 2017
    N1  - https://doi.org/10.11648/j.aff.20170606.15
    DO  - 10.11648/j.aff.20170606.15
    T2  - Agriculture, Forestry and Fisheries
    JF  - Agriculture, Forestry and Fisheries
    JO  - Agriculture, Forestry and Fisheries
    SP  - 214
    EP  - 218
    PB  - Science Publishing Group
    SN  - 2328-5648
    UR  - https://doi.org/10.11648/j.aff.20170606.15
    AB  - Fatty liver disease is characterized by the accumulation of triglycerides and other fats in the liver cells and is believed to be a risk of later chronic liver disease. Diet is one of the key ways to treat fatty liver disease. Octopus (Enterocopus dofleini) liver is eaten in some regions in Japan, but mostly discarded. For utilization of octopus liver, the lipid-lowering effect of octopus (Enterocopus dofleini) liver extract was investigated using human hepatoma cells (HepG2 cells). The present study showed that the octopus liver extract reduced the triglyceride content, but not cholesterol content, in HepG2 cells. Treatment with the octopus liver extract increased the mRNA expression of genes for peroxisome proliferator-activated receptor (PPAR)-α, medium chain acyl-CoA dehydrogenase (MCAD), and acyl-CoA oxidase (ACO) associated with β-oxidation. On the contrary, the extract did not change the mRNA expression of genes for sterol regulatory element-binding protein (SREBP)-1, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD)-1, and peroxisome proliferator-activated receptor (PPAR)-γ involved in fatty acid synthesis. These results suggest that octopus liver extract may decrease the triglyceride level in HepG2 cells by promoting β-oxidation, suggestive of its usefulness as a food for lowering triglycerides in liver.
    VL  - 6
    IS  - 6
    ER  - 

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