Synthesis, in vitro Anticancer Activity Evaluation and Docking Investigations of Novel Aromatic Chalcones
Modern Chemistry
Volume 1, Issue 1, February 2013, Pages: 1-7
Received: Nov. 26, 2012; Published: Feb. 20, 2013
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Authors
Vankadari Srinivasarao, Department of chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, India
Chaturvedula Radha Krishna, Department of chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, India
Macha Ramesh, Department of chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, India
Tigulla Parthasarathy, Department of chemistry, University College of Science, Osmania University, Saifabad, Hyderabad, India
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Abstract
In a wide search program toward new anticancer agents, a series of Aromatic chalcones have been synthesized by condensing benzaldehyde derivatives with arylmethylcetone in potassium hydroxide ethanol according to the Claisen-Schmidth condensation at room temperature. The synthetic chalcones have been determined by IR spectroscopy and 1H-NMR spectroscopy. The anticancer activitiesof the compounds were evaluated against in vitro using human tumour cell lines of Jurkat and HL-60 cell lines and MTT assay. From the series, two compounds(4,15) exhibited potent growth inhibi-tory effects against the proliferation of human T-lymphocyte leukemia compared to the parent unsubstitutedchalcone. The result shows that the electron donating groups moiety may increase anticancer activity. Aromatic chalcones with hydroxyl group,methoxy group on A ring at positions 2 or 3 are considered as lead compounds for generation of new potential anticancer drugs in future.Similarly,the compounds(7,12) exhibited potent growth inhibitory effects against HL-60 cells. The results are very encouraging. Future studies include testing the compounds in vivo with and without radiation. Docking studies with 1NKP have shown that the compound 17 has highest IC50 against human leukemia cells (HL-60).
Keywords
Aromatic Chalcones Synthesis, Anticancer Activity, Docking Studies, Mtt Assay
To cite this article
Vankadari Srinivasarao, Chaturvedula Radha Krishna, Macha Ramesh, Tigulla Parthasarathy, Synthesis, in vitro Anticancer Activity Evaluation and Docking Investigations of Novel Aromatic Chalcones, Modern Chemistry. Vol. 1, No. 1, 2013, pp. 1-7. doi: 10.11648/j.mc.20130101.11
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