Enamines in Heterocyclic Synthesis: Route to Aminopyrazolopyrimidines and Arylpyrazolopyrimidiens Derivatives
Modern Chemistry
Volume 2, Issue 1, February 2014, Pages: 1-5
Received: Feb. 20, 2014; Published: Mar. 30, 2014
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Hanadi Yousef. Medrasi, Department of Chemistry, Sciences faculty for Girls, King Abdulaziz University, Jeddah, Jeddah, KSA
Abdellatif Mohamed Salaheldin, Department of Chemistry, College of Applied Sciences, Umm Al-Qura University, Makkah, KSA
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An easy preparation of enaminonitrile derivatives, obtained by using a mixture of triethyl orthoformate and piperidine in DMF solution, and their transformation into new substituted azolopyrimidines is described. The one-step transformation was carried out under microwave irradiation and by classical heating methods. The use of microwave irradiation led to high conversion and shorter reaction times.
Pyrazolopyrimidines, Enamines, Aminopyrazole, Microwave Irradiation
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Hanadi Yousef. Medrasi, Abdellatif Mohamed Salaheldin, Enamines in Heterocyclic Synthesis: Route to Aminopyrazolopyrimidines and Arylpyrazolopyrimidiens Derivatives, Modern Chemistry. Vol. 2, No. 1, 2014, pp. 1-5. doi: 10.11648/j.mc.20140201.11
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