Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents
Volume 2, Issue 2, April 2014, Pages: 6-14
Received: Apr. 22, 2014;
Accepted: May 13, 2014;
Published: May 30, 2014
Views 3242 Downloads 294
Mohammad Nasir Uddin, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
Didarul Alam Chowdhury, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
Md. Moniruzzman Rony, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
Md. Ershad Halim, Department of Chemistry, University of Dhaka, Dhaka, Bangladesh
Follow on us
The Schiff bases, formed by condensation of 2-thiophenecarboxaldehyde with 2-aminothiophenol (LH) and propane-1,2-diamine (L1), and their complexes of Ni(II), Cu(II), Zn(II) and Cd(II) have been prepared and characterized by elemental analysis, and magnetic and spectroscopic measurements. Infrared and NMR spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the sulfur atom of the thiophene ring. Magnetic susceptibility data coupled with electronic suggest octahedral structure for the complexes. Conductance measurements suggest the non-electrolytic nature of the complexes. Stoichiometry of complexes has been suggested as [M(L)2] and [ML1Cl2]. The Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four human pathogenic bacteria. Ligands show moderately whereas some of metal chelates show highly antibacterial activity against them.
Metal Complexes, Schiff Bases, 2-Thiophenecarboxaldehyde, 2-Aminothiophenol, Propane-1, 2-Diamine, Antibacterial Activity
To cite this article
Mohammad Nasir Uddin,
Didarul Alam Chowdhury,
Md. Moniruzzman Rony,
Md. Ershad Halim,
Metal Complexes of Schiff Bases Derived from 2-Thiophenecarboxaldehyde and Mono/Diamine as the Antibacterial Agents, Modern Chemistry.
Vol. 2, No. 2,
2014, pp. 6-14.
M Vikotora; K Rudolfa; L Molbank. M354 Open Access Publication, 2004.
A Ahmed; MA El-Sherif; T Eldebss. Spectrochimica Acta Part A, 2011, 79, 1803-1814.
N Sari; P Gürkan. Z. Naturforsch. 2004, 59b, 692 – 698.
K Jamuna; BR Naik; B Sreenu; K Seshaiah. J. Chem. Pharm. Res., 2012, 4(9), 4275-4282.
M Montazerozohori; M Sedighipoor; S Joohari. Int. J. Electrochem. Sci., 2012, 7, 77– 88.
DA Chowdhury; MN Uddin; F Hoque. Chiang Mai J. Sci. 2010, 37(3), 443-450.
DA Chowdhury; MN Uddin; MAH Sarker; Chiang Mai J. Sci. 2008, 35(3), 483-494.
DA Chowdhury; MN Uddin; GK Chowdhury. The Chitt. Uni. J. of Sci. 2006, 30(1), 85-88.
MN Uddin; DA Chowdhury; K Hossain, J. Chinese Chem. Soc., 2012, 59(12), 1520-1527.
C SṕInu; M Pleniceanu; C Tigae. Turk J Chem, 2008, 32, 487– 493.
OB Ibrahim; MA Mohamed; MS Refat. Int. J. of Innovative Res. in Sci., Eng. and Tech. 2013, 2(11), 6355-6570.
C Spinu; A Kriza; Acta Chim. Slov. 2000, 47, 179-185.
MN Uddin; DA Chowdhury; MT Islam; F Hoque. Orbital Elec. J. Chem. 2012, 4(4), 273-287.
AP Mishra; A Tiwari; R Jain. Int. J. Res. Pharm. Sci. 2011, 3(2), 186-191.
J Bjerrum. “Metal Amine For-mation in Aqueous Solution, Haase, Copenhagen, 1941.