Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex
Modern Chemistry
Volume 3, Issue 2, April 2015, Pages: 18-30
Received: Apr. 1, 2015; Accepted: Apr. 7, 2015; Published: Apr. 27, 2015
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Tarek M. Ismail, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Mosad A. EL Ghamry, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Samy M. Abu-El-Wafa, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
Doaa F. Sallam, Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt
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Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu- Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.
Sulphaquinoxaline, Schiff Base, Metal Complexes, Spectral Studies, Antimicrobial, Anticancer Activity, Nano Complexes
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Tarek M. Ismail, Mosad A. EL Ghamry, Samy M. Abu-El-Wafa, Doaa F. Sallam, Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex, Modern Chemistry. Vol. 3, No. 2, 2015, pp. 18-30. doi: 10.11648/
S. Kumar, D. N. Dhar, P. N. Saxena, J. Scientific and Industrial Research. 68 (2009) 181-187.
M. M. H. Khalil, E. H. Ismail, G. G. Mohamed, E. M. Zayed and A. Badr, Open Journal of Inorganic chemistry, 2 (2012) 13-21.
Katarzyna BRODOWSKA, Elżbieta ŁODYGA-CHRUŚCIŃSKA, CHEMIK, 68 (2014) 129-134.
A. Iqbal, H. L. Siddiqui, C. M. Ashraf, M. H Bukhari C. M. Akram, Pharm. Bull. 55 (2007) 1070.
A. Lalehzari, J. Desper, C. J. Levy, Inorg. Chem. 47(2008) 1120.
S. Shit, S. Sen, S. Mitra, D. L. Hughes, Transition Met. Chem3. (2009) 269.
Xu, B.; Jiang, W.; Zhang, J.; Tang, Y.; Li, J. Transition Met. Chem. 34 (2009) 293.
G. B.. Bagihalli, P. G. Avaji, S. A. Patil, P. S. Badami, Eur. J. Med. Chem. 43 (2008) 2639-2649.
Z. H. Chohan, M. Arif, A. J. Rashid, J. Enzyme Inhib. Med. Chem. 23 (2008) 785.
K. Siddappa and Nabiya Sultana Mayana, Int J Pharm Bio Sci, 5(4) (2014) 162-174.
H. Mastubara, Botyk Kogaku, (1954) 15.
M. Forbes F. Zilliikan, G. Robert, P. Gyorgy, J. Am. Chem. Soc. 80 (1985) 385.
A. H.. Rahaman, E. M. Khendel, J. Indian. Chem. Soc. 58 (1981), 404.
R. A.. Scherrer, US Patent. 3 (1975), 927.
S. B. Kadin, J. Med. Chem. 15 (1972) 551.
J. W. Mason, N. J. Eng, Med. Chem. 31(1987) 455.
Y. Kawas, M. Nakayama, P. Tamatskuri, Bull. Chem. Soc. Japan. 35 (1962) 149.
C. M. da Silva, D. L. Da Silva, L. V. Modolo, R. B. Alves, M. A. De Resende, C. V. B. Martins, A. de Fatima, J. Adv. Res. 2 (2011) 1–8.
E. J. Threlfall, I. S. T. Fisher, L. Ward, H. Tschape, P. Gerner-Smidt, Microb. Drug Resist. 5 (1999) 195-199.
J. F. Prescott, J. D Baggot, R. D. Walker, In Antimicrobial Therapy in Veterinary Medicine, Iowa State University Press, Ames, Iowa, (2000).
J. Sambrook, E. F. Fritsch, T. Maniatis, Molecular Cloning, A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory, New York (1989).
W. J. Geary, Coord. Chem. Rev. 7 (1971) 81-122.
J. T. Hu, T. W. Odom, C. M. Lieber, Acc. Chem. Res. 32 (5) (1999) 435.
J. D. Holmes, K. P. Johnston, R. C. Doty, B. A. Korgel, Science. 287 (2000) 5457.
N. Agrait, N. J. Rodrigo, S. Vieria, Phys. Rev. B 47 (1993) 12345.
N. Duxin, O. Stephan, C. Petit, P. Bonville, C. Colliex, M. P. Pileni, Chem. Mater. 9(1997) 2096.
Nadia El-Wakiel, Yusif El-Sayed, Mohamed Gaber, Journal of Molecular Structure, 1001 (2011) 1-11.
R. M. Wang, N. P. He, P. F. Song, Yu-F. He, L. Ding, Z. Q. Lei, Polym. Adv. Technol. 20 (2009) 959.
A. I. Vogel, A Text Book of Quantitative Inorganic Analysis, 3rd ed., Longman ELBS, London. (1968).
S. P. Gubin, N. A. Kataeva, Coordination Chemistry of Nanoparticles, Russ. J. Coord. Chem. 32 (12) (2006) 849.
V. Safarifard, A. Morsali, Ultrason. Sonochem. 19 (2012) 823.
R. S Razavi, M. R. LoghmanEstarki, J. Clust. Sci . 23 (2012) 1097.
N. V. Suramwar, S. R Thakare, N. T. Khaty, Int. J. Nano Dimens. 3 (2012) 75.
A. A. Athawale, P. P Kater, M. Kumar, M. B. Majumdar, copper nanoparticles, Mater. Chem. Phys. 91 (2005) 507-512.
T. M. A. Ismail, A. A. Saleh, M. A. El Ghamry, Spectrochimica Acta Part A. 86 (2012) 276
K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th ed., JohnWiley, Nature. 68 (1964) 201.
A. W. Coats, J. P. Redfern Metal Chem. 26 ( 2001) 532-537
C. R. Vinodkumar, M. K. Muraleedharan Nair and P. K. Radhakrishnan, J. Therm. Anal. Cal. , 143, 61 (2000); A. A. Frost, R. G. Pearson, Kineticks, Mechanisms, Willey, New York (1961).
A. L Sharma, I. O, singh, H. R. singh, R. M Kadam, M. K Bhide, M. D. Snstry, Transit and Sons, New York, (1986).
O. fOzturk, A Cansiz, M. Koparir, Transit Metal Chem. 32( 2007) 224-227.
A. A. Saleh, J. Coord. Chem. 58 (3) (2005) 255–270.
M. Mashaly, T. M. Ismail, S. B. E. L. Maraghy, H. A. Habib, J. Coord. Chem. 57 (13) (2004) 1099–1123.
A. B. P. Lever, Inorganic Electronic Spectroscopy, Elsevier, New York, (1984).
T. M. A. Ismail, J. Coord. 58 (2) (2005) 141-151.
Y. Bodke, S. S. Sangapure, J. Indian Chem. Soc. 80 (2003) 187.
D. N. Satyanarayana, Electronic Absorption Spectroscopy and Related Techniques, Universities Press (India) Limited, New Delhi, (2001).
N. O. Obi-Egbedi, I. B. Obot, M. I. El-Khaiary, S. A. Umoren and E. E. Ebenso, Int. J. Electrochem. Sci. 6 (2011) 5649-5675.
D. Kivelson, R. Neiman, J. Chem. Phys. 35 (1961) 149.
N. Raman A. Sakthivel, K. Rajasekaran, J. Coord. Chem. 62 (2009) 1661.
S Belaid, A. Landreau, S. Djebbar, O. Benali-Baitich, G. Bouet, J. P. Bouchara, J. Inorg. Biochem. 55( 2008)102,
D. Kivelson, R. Neiman, J. Chem. Phys. 35 (1961) 149.
A. Kulkarni, S. A Patil, P. S. Badami, Eur. J. Med. Chem. 44 (2009) 2904-2912.
N. Raman, A. Sakthivel, K. Rajasekaran, J. Coord. Chem. 6 (2009) 1661.
S. Amer, N. El-Wakiel, H. El-Ghamry, Journal of Molecular Structure 1049 (2013) 326-335.
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