The Application of Lab Environment as the External Disturbance in the 3-Stage IR Method for the Facile Discrimination of Danggui Formula Granules
Modern Chemistry
Volume 6, Issue 2, June 2018, Pages: 15-19
Received: Jun. 13, 2018; Accepted: Jun. 28, 2018; Published: Jul. 23, 2018
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Authors
Bi Xiaodong, Department of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Traditional Chinese Medicine Formula Granule Engineering & Technology Research Center, Shijiazhuang, China; Traditional Chinese Medicine Formula Granule Research Center of Hebei Province University, Shijiazhuang, China
Ma Jingmei, Department of Laboratory Center, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Traditional Chinese Medicine Formula Granule Engineering & Technology Research Center, Shijiazhuang, China; Traditional Chinese Medicine Formula Granule Research Center of Hebei Province University, Shijiazhuang, China
Tian Wei, Department of Laboratory Center, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Traditional Chinese Medicine Formula Granule Engineering & Technology Research Center, Shijiazhuang, China; Traditional Chinese Medicine Formula Granule Research Center of Hebei Province University, Shijiazhuang, China
Peng Xinhua, Shineway Pharmaceutical Group Ltd, Shijiazhuang, China
Gao Han, Shineway Pharmaceutical Group Ltd, Shijiazhuang, China
Li Junshan, Shineway Pharmaceutical Group Ltd, Shijiazhuang, China
Niu Liying, Department of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China; Hebei Traditional Chinese Medicine Formula Granule Engineering & Technology Research Center, Shijiazhuang, China; Traditional Chinese Medicine Formula Granule Research Center of Hebei Province University, Shijiazhuang, China
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Abstract
Formula granule (FG), as an improved preparation form of traditional liquid dedoction, is of increasing interest and hence it is necessary to develop facile analytical or discrimination methods. Based on the established 3-Stage IR method, a new external disturbance of lab environment (LE) in which room temperature (RT) is 25-30°C and humidity is 25-30%, is introduced to test its applicability in discrimination of Danggui formula granules from different companies in which the LE is used to affect the prepared KBr pellet to produce enough variations for the 3S-IR method. Firstly, the 2D-spectra and pattern recognition algorithm of principal component analysis (PCA) and hierarchical cluster analysis (HCA) are used to select the analytical basis for 2D-COS IR. Secondly, LE-based 2D-COS IR is used for the discrimination. The newly-established LE-based IR can avoid the complex parts of programmed temperature and sampling in IR instrument, and achieve the discrimination of different Danggui Formula Granules.
Keywords
Formula Granule, Danggui, IR, Lab Environment, Discrimination
To cite this article
Bi Xiaodong, Ma Jingmei, Tian Wei, Peng Xinhua, Gao Han, Li Junshan, Niu Liying, The Application of Lab Environment as the External Disturbance in the 3-Stage IR Method for the Facile Discrimination of Danggui Formula Granules, Modern Chemistry. Vol. 6, No. 2, 2018, pp. 15-19. doi: 10.11648/j.mc.20180602.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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