The synthesis of myristicin ketone from myristicin has been achieved through conversion of allyl group to ketone. Myristicin was isolated from nutmeg oil. The reaction of myristicin with mercury acetate in aqueous tetrahydrofuran, followed by in situ reduction of the mercurial intermediate by alkaline solution sodium borohydride produced myristicin alcohol. Myristicin alcohol was oxidized with PCC at 40 0C for 90 minutes, followed by purified with saturated potassium disulphite yield myristicin ketone (3-methoxy-4,5-methylenedioxyphenyl)-2-propanone (68.32%).
| Published in | Science Journal of Chemistry (Volume 3, Issue 3) |
| DOI | 10.11648/j.sjc.20150303.15 |
| Page(s) | 62-66 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Myristicin Ketone, Myristicin, Nutmeg Oil
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APA Style
Hanoch Julianus Sohilait, Healthy Kainama. (2015). Synthesis of Myristicin Ketone (3,4-Methylenedioxy-5-Methoxyphenyl)-2-Propanone from Myristicin. Science Journal of Chemistry, 3(3), 62-66. https://doi.org/10.11648/j.sjc.20150303.15
ACS Style
Hanoch Julianus Sohilait; Healthy Kainama. Synthesis of Myristicin Ketone (3,4-Methylenedioxy-5-Methoxyphenyl)-2-Propanone from Myristicin. Sci. J. Chem. 2015, 3(3), 62-66. doi: 10.11648/j.sjc.20150303.15
AMA Style
Hanoch Julianus Sohilait, Healthy Kainama. Synthesis of Myristicin Ketone (3,4-Methylenedioxy-5-Methoxyphenyl)-2-Propanone from Myristicin. Sci J Chem. 2015;3(3):62-66. doi: 10.11648/j.sjc.20150303.15
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Download@article{10.11648/j.sjc.20150303.15,
author = {Hanoch Julianus Sohilait and Healthy Kainama},
title = {Synthesis of Myristicin Ketone (3,4-Methylenedioxy-5-Methoxyphenyl)-2-Propanone from Myristicin},
journal = {Science Journal of Chemistry},
volume = {3},
number = {3},
pages = {62-66},
doi = {10.11648/j.sjc.20150303.15},
url = {https://doi.org/10.11648/j.sjc.20150303.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20150303.15},
abstract = {The synthesis of myristicin ketone from myristicin has been achieved through conversion of allyl group to ketone. Myristicin was isolated from nutmeg oil. The reaction of myristicin with mercury acetate in aqueous tetrahydrofuran, followed by in situ reduction of the mercurial intermediate by alkaline solution sodium borohydride produced myristicin alcohol. Myristicin alcohol was oxidized with PCC at 40 0C for 90 minutes, followed by purified with saturated potassium disulphite yield myristicin ketone (3-methoxy-4,5-methylenedioxyphenyl)-2-propanone (68.32%).},
year = {2015}
}
TY - JOUR T1 - Synthesis of Myristicin Ketone (3,4-Methylenedioxy-5-Methoxyphenyl)-2-Propanone from Myristicin AU - Hanoch Julianus Sohilait AU - Healthy Kainama Y1 - 2015/06/11 PY - 2015 N1 - https://doi.org/10.11648/j.sjc.20150303.15 DO - 10.11648/j.sjc.20150303.15 T2 - Science Journal of Chemistry JF - Science Journal of Chemistry JO - Science Journal of Chemistry SP - 62 EP - 66 PB - Science Publishing Group SN - 2330-099X UR - https://doi.org/10.11648/j.sjc.20150303.15 AB - The synthesis of myristicin ketone from myristicin has been achieved through conversion of allyl group to ketone. Myristicin was isolated from nutmeg oil. The reaction of myristicin with mercury acetate in aqueous tetrahydrofuran, followed by in situ reduction of the mercurial intermediate by alkaline solution sodium borohydride produced myristicin alcohol. Myristicin alcohol was oxidized with PCC at 40 0C for 90 minutes, followed by purified with saturated potassium disulphite yield myristicin ketone (3-methoxy-4,5-methylenedioxyphenyl)-2-propanone (68.32%). VL - 3 IS - 3 ER -
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