Isoniazid Containing Metal Based Drugs as Potential Antimicrobial Agent: A Short Review
Science Journal of Chemistry
Volume 5, Issue 5, October 2017, Pages: 62-70
Received: Jul. 17, 2017; Accepted: Jul. 31, 2017; Published: Sep. 18, 2017
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Authors
Md. Saddam Hossain, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Abdul Mannan, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
F. K. Camellia, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
A. K. B. Zaman, Department of Dermatology, Barind Medical College and Hospital, Rajshahi, Bangladesh
C. M. Zakaria, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
Md. Kudrat-E-Zahan, Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh
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Abstract
Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review we have focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-tuberculosis, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of isoniazid containing synthetic metal complexes.
Keywords
Metal Based Drugs, Antibacterial, Antifungal, Anti-Tuberculosis, Anti-Cancer, DNA-Interaction and Anti-Tumor Activity
To cite this article
Md. Saddam Hossain, Md. Abdul Mannan, F. K. Camellia, A. K. B. Zaman, C. M. Zakaria, Md. Kudrat-E-Zahan, Isoniazid Containing Metal Based Drugs as Potential Antimicrobial Agent: A Short Review, Science Journal of Chemistry. Vol. 5, No. 5, 2017, pp. 62-70. doi: 10.11648/j.sjc.20170505.11
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Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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