Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin
Science Journal of Chemistry
Volume 7, Issue 3, June 2019, Pages: 67-71
Received: Jun. 12, 2019; Accepted: Jul. 23, 2019; Published: Sep. 17, 2019
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Olawale Folorunso Akinyele, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Oluwatola Akinnusi, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Temitope Adekunle Ajayeoba, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Ayowole Olaolu Ayeni, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
Lateefah Moyosore Durosinmi, Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Nigeria
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Co(II), Ni(II), and Cu(II) complexes of aroylhydrazone mixed with aspirin were synthesized and characterized by percentage metal analysis, infrared and electronic spectroscopy, melting point, solubility, molar conductance and room temperature magnetic moment measurements. Infrared spectra data revealed that the aspirin behaved as a bidentate ligand with coordination via carboxylate and carbonyl groups while the hydrazine coordinated via the azomethine nitrogen atom and carbonyl oxygen atom in the aroylhydrazone. The room temperature magnetic moment and electronic spectral data that the metal complexes possessed octahedral geometry. The molar conductance measurements of all the metal complexes in DMF indicated that they are non-electrolytes. The in vitro antimicrobial activities studies showed that the Cu(II) complex had the best activity against tested bacteria; Streptococcus spp, B. subtlis and vibro spp with inhibitory zones range of 2.0 - 6.0 mm, while the Ni(II) complex showed considerable activity against gram negative bacteria; Shigella spp with inhibitory zone of 10.0 mm suggesting its potential as an antimicrobial agent.
Antimicrobial, Aroylhydrazone (HL), Aspirin (HASA), Carboxylate, Azomethine
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Olawale Folorunso Akinyele, Temitope Oluwatola Akinnusi, Temitope Adekunle Ajayeoba, Ayowole Olaolu Ayeni, Lateefah Moyosore Durosinmi, Synthesis, Characterization and Antimicrobial Activities of Cobalt(II), Nickel(II) and Copper(II) Complexes of Aroylhydrazone Mixed with Aspirin, Science Journal of Chemistry. Vol. 7, No. 3, 2019, pp. 67-71. doi: 10.11648/j.sjc.20190703.13
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