Crystal Structure of Diisopropylammonium Hydrogen Maleate
Science Journal of Chemistry
Volume 7, Issue 6, December 2019, Pages: 110-113
Received: Jan. 7, 2020; Accepted: Jan. 29, 2020; Published: Feb. 11, 2020
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Authors
Dame Seye, Mineral and Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Assane Toure, Mineral and Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Momath Lo, Laboraory of Organic Physical Chemistry Instrumental Analysis, Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Cheikh Abdoul Khadir Diop, Mineral and Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
Libasse Diop, Mineral and Analytical Chemistry Laboratory, Department of Chemistry, Faculty of Science and Technology, Cheikh Anta Diop University, Dakar, Senegal
David Geiger, Department of Chemistry, Geneseo Faculty, State University of New York, Geneseo, New York, USA
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Abstract
Use of salts and co-crystals of active pharmaceutical ingredients (APIs) as a method for tuning their delivery and activity is an area of growing interest. Modifying API properties such as solubility by finding new salts that employ similar hydrogen-bonding have been successful. In an effort to further study the hydrogen-bonding patterns of the maleate ion with other diisopropylammonium we report here the synthesis and diisopropylammonium maleate. The salt was isolated from reaction between diisopropylamine and maleic acid in methanol. The results of elementary analyzes (CHN) showed the presence of the nitrogen atom of diisopropylamine, carbon atoms and hydrogen. The IR spectrum of diisopropylammonium hydrogen maleate, showed the presence of two intense bands due to the vibrations of symmetricand anti-symmetric valence of the carboxylate group and a wide absorption due to the NH2 groups of the cation. Those which has been confirmed by crystallography. The asymmetric unit contains one diisopropylammonium cation, iPr2NH2+ and one hydrogen maleate anion. In the structure, anions which present an inner O-H…O hydrogen bond are linked to cations through N-H…O hydrogen bonds leading to infinite chains. Chains are connected to their neighbours through weak C-H…O hydrogen bonds affording a layer. The study of the interactions of diisopropylammonium hydrogen menaleate, by the presence of hydrogen bonds leading to supramolecular architectures has shown the possibility of its use in Active Pharmaceutical Ingrédients (API).
Keywords
Crystal Structure, Diisopropylammonium, Maleate, Hydrogen Bonds, Sheet
To cite this article
Dame Seye, Assane Toure, Momath Lo, Cheikh Abdoul Khadir Diop, Libasse Diop, David Geiger, Crystal Structure of Diisopropylammonium Hydrogen Maleate, Science Journal of Chemistry. Vol. 7, No. 6, 2019, pp. 110-113. doi: 10.11648/j.sjc.2019070612
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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