Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids
Science Journal of Chemistry
Volume 8, Issue 1, February 2020, Pages: 1-6
Received: Jan. 23, 2020; Accepted: Feb. 13, 2020; Published: Mar. 2, 2020
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Authors
James Tembei Titah, Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Coulibaly Wacothon Karime, Department of Chemistry and Biochemistry, Peleforo Gon Coulibaly University, Korhogo, Ivory Coast
Kevin Chambers, Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Anita Balogh, Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Kevin Joannou, Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
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Abstract
Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.
Keywords
Amino Acids, Characterization, Schiff-Bases, Synthesis, Biological Activities, Imine Group
To cite this article
James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou, Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids, Science Journal of Chemistry. Vol. 8, No. 1, 2020, pp. 1-6. doi: 10.11648/j.sjc.20200801.11
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Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
A. M. Abu-Dief, and I. M. A. Mohamed, Beni-Suef University Journal of Basic and Applied Sciences, 2015, (4), pp 119-133.
[2]
a. H. L. Singh and J. Singh, Int. J. of Inorg. Chem., 2013, (vol 2013), pp 1-10, b. K. Ghosh et al., RSC Advances, 2018, (8), pp 28216-28237.
[3]
a. M. Alias, H. Kassum and C. Shakir, JAAUBAS, 2014, (vol. 15), pp 28-34, b. Mohamed Gaber et al., Journal of Iranian Chemical Society, 2019, (16), pp 169-182.
[4]
Kangah Niameke Jean-Baptiste et al., International Journal of Pharmaceutical Science Invention, 2019, (8), issue II, pp 48-54.
[5]
N. K. Chaudhary and P. Mishra, bioinorganic chemistry and applications, 2017, pp 1-13.
[6]
T. Mangamamba, M. C. Ganorkar, and G. Swarnabala, International Journal of Inorganic Chemistry, 2014, pp 1-22.
[7]
Emad Yousif et al., Arabian Journal of Chemistry, 2017, (10), pp S1639-S1644.
[8]
Majid Rezaeivala, Journal of Saudi Chemical Society, 2017, (21), pp 420-424.
[9]
ElieneLeandrodeAraújo et al., International Journal of Biological Macromolecules, 2017, (95), pp 168-176.
[10]
Rathore et al., Eur. J. Chem. 2010, pp. S566–S572 7 (S1).
[11]
E. Yousif et al., Arabian, J. Chem., 2013, pp 1-5.
[12]
Chohan Z. H., Arif M., Akhtar M. A., Supuran C. T., Bioinorganic Chemistry and Application, 2006, pp 1-13.
[13]
El-Sherif A. A., Aljahdali M. S., Journal of Coordination Chemistry, 2013, 66 (19): pp 3423-3468.
[14]
Rimbu C., Danac R., Pui A., Chem Pharm Bull., 2014, 62 (1), pp 12-15.
[15]
De Souza A. O., Galetti F. C. S., Silva C. L., Bicalho B., Parma M. M., Fonseca S. F., Marsaioli A. J., Trindade A. C. L. B., Gil R. P. F., Bezerra F. S., Quimica Nova, 2007, (30), pp 1563-1566.
[16]
Guo Z., Xing R., Liu S., Zhong Z., Ji X., Wang L., Li P. Carbohydr Res., 2007, (342), 1329-1332.
[17]
G. L. Miessler, P. J. Fisher, and D. A. Tarr, Inorganic Chemistry, 2013, 5th Edition.
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