Large Scale Process to Prepare Highly Pure Bosentan Monohydrate
Science Journal of Chemistry
Volume 2, Issue 6-1, December 2014, Pages: 9-15
Received: Aug. 28, 2014; Accepted: Sep. 15, 2014; Published: Sep. 23, 2014
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Authors
Amala Kompella, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
Srinivasu Kasa, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
Veera Swami Balina, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
Subhash Kusumba, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
Bhujanga Rao Kalisatya Adibhatla, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
Pulla Reddy Muddasani, Natco Research Centre, B-13, Industrial Estate, Sanath Nagar, Hyderabad, India
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Abstract
Described is an improved process for the preparation of highly pure Bosentan monohydrate (>99.8% HPLC purity) 1 with pyrimidinone 8 and the dimer 9 impurities to less than 0.10% of HPLC analysis. The present work also provides processes for the preparation of pyrimidinone 8 and dimer 9 impurities.
Keywords
Bosentan monohydrate, highly pure, Pulmonary artery hypertension
To cite this article
Amala Kompella, Srinivasu Kasa, Veera Swami Balina, Subhash Kusumba, Bhujanga Rao Kalisatya Adibhatla, Pulla Reddy Muddasani, Large Scale Process to Prepare Highly Pure Bosentan Monohydrate, Science Journal of Chemistry. Special Issue: Green Chemistry: Synthesis and Its Uses. Vol. 2, No. 6-1, 2014, pp. 9-15. doi: 10.11648/j.sjc.s.2014020601.12
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