Automation, Control and Intelligent Systems

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Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway

Received: 21 December 2014    Accepted: 25 December 2014    Published: 18 January 2015
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Abstract

Macrophages are mononuclear phagocytes generated from monocyte emigrated from blood circulation. Macrophages mediated the innate and adaptive immunity through different routes, and cytokine production is one of these routes. Signal transducer and activators of transcription (STATs) are cytoplasmic transcription factors that are key mediators of cytokine and growth factor signalling pathways. STAT-3 is implicated in macrophage cytokine signalling and production. It's well reported that the microbiota is very important as it primes the immune system for the antigens encountered later in life. Probiotics defined as ‘Live microorganisms which when administered in adequate amounts confer a health benefit on the host. Therefore, the aim of this project was to answer the question whether probiotics induced cytokine production via activation of STAT-3 signalling pathway.Results showed that probiotic Lactobacillus casie strain Shirota was successfully induced cytokine production via activation of STAT-3 by anti-inflammatory macrophages induced by TNF-α. The findings of this study will open new strategy to modulate the immune response by probiotic bacterialeading to treat the diseasesthat related with irregular cytokine production.

DOI 10.11648/j.acis.s.2015030201.11
Published in Automation, Control and Intelligent Systems (Volume 3, Issue 2-1, March 2015)

This article belongs to the Special Issue Artificial Nano Sensory System

Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Macrophages, Probiotics, Cytokines, STAT-3

References
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  • APA Style

    Neama Y, Habil. (2015). Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway. Automation, Control and Intelligent Systems, 3(2-1), 1-7. https://doi.org/10.11648/j.acis.s.2015030201.11

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    Neama Y; Habil. Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway. Autom. Control Intell. Syst. 2015, 3(2-1), 1-7. doi: 10.11648/j.acis.s.2015030201.11

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    AMA Style

    Neama Y, Habil. Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway. Autom Control Intell Syst. 2015;3(2-1):1-7. doi: 10.11648/j.acis.s.2015030201.11

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  • @article{10.11648/j.acis.s.2015030201.11,
      author = {Neama Y and Habil},
      title = {Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway},
      journal = {Automation, Control and Intelligent Systems},
      volume = {3},
      number = {2-1},
      pages = {1-7},
      doi = {10.11648/j.acis.s.2015030201.11},
      url = {https://doi.org/10.11648/j.acis.s.2015030201.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.acis.s.2015030201.11},
      abstract = {Macrophages are mononuclear phagocytes generated from monocyte emigrated from blood circulation. Macrophages mediated the innate and adaptive immunity through different routes, and cytokine production is one of these routes. Signal transducer and activators of transcription (STATs) are cytoplasmic transcription factors that are key mediators of cytokine and growth factor signalling pathways. STAT-3 is implicated in macrophage cytokine signalling and production. It's well reported that the microbiota is very important as it primes the immune system for the antigens encountered later in life. Probiotics defined as ‘Live microorganisms which when administered in adequate amounts confer a health benefit on the host. Therefore, the aim of this project was to answer the question whether probiotics induced cytokine production via activation of STAT-3 signalling pathway.Results showed that probiotic Lactobacillus casie strain Shirota was successfully induced cytokine production via activation of STAT-3 by anti-inflammatory macrophages induced by TNF-α. The findings of this study will open new strategy to modulate the immune response by probiotic bacterialeading to treat the diseasesthat related with irregular cytokine production.},
     year = {2015}
    }
    

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    T1  - Probiotic Induce Macrophage Cytokine Production Via Activation of STAT-3 Pathway
    AU  - Neama Y
    AU  - Habil
    Y1  - 2015/01/18
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    DO  - 10.11648/j.acis.s.2015030201.11
    T2  - Automation, Control and Intelligent Systems
    JF  - Automation, Control and Intelligent Systems
    JO  - Automation, Control and Intelligent Systems
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    PB  - Science Publishing Group
    SN  - 2328-5591
    UR  - https://doi.org/10.11648/j.acis.s.2015030201.11
    AB  - Macrophages are mononuclear phagocytes generated from monocyte emigrated from blood circulation. Macrophages mediated the innate and adaptive immunity through different routes, and cytokine production is one of these routes. Signal transducer and activators of transcription (STATs) are cytoplasmic transcription factors that are key mediators of cytokine and growth factor signalling pathways. STAT-3 is implicated in macrophage cytokine signalling and production. It's well reported that the microbiota is very important as it primes the immune system for the antigens encountered later in life. Probiotics defined as ‘Live microorganisms which when administered in adequate amounts confer a health benefit on the host. Therefore, the aim of this project was to answer the question whether probiotics induced cytokine production via activation of STAT-3 signalling pathway.Results showed that probiotic Lactobacillus casie strain Shirota was successfully induced cytokine production via activation of STAT-3 by anti-inflammatory macrophages induced by TNF-α. The findings of this study will open new strategy to modulate the immune response by probiotic bacterialeading to treat the diseasesthat related with irregular cytokine production.
    VL  - 3
    IS  - 2-1
    ER  - 

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