Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride
American Journal of Theoretical and Applied Statistics
Volume 2, Issue 3, May 2013, Pages: 81-86
Received: May 29, 2013; Published: Jun. 20, 2013
Views 3182      Downloads 172
Authors
Younes Abrouki, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Abdelkader Anouzla, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Hayat Loukili, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Rabiaâ Lotfi, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Ahmed Rayadh, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Abdellah Bahlaoui, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Saı̈d Sebti, Department of Chemistry, Faculty of Science Ben M'Sik, University Hassan II, Casablanca, Morocco
Driss Zakarya, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Mohamed Zahouily, Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco
Article Tools
PDF
Follow on us
Abstract
The optimization of the synthesis of anti-tuberculosis drug by thia-Michael addition between thiophenol and chalcone catalyzed using activated Fluorapatite supported potassium fluoride (KF/FAP) was studied using a 2 block central composite design including 4 factors (reaction time, solvent volume, catalyst weight and impregnation ratio). The high reactivity and regioelectivity of our catalyst coupled with their ease of use and reduced environmental problems makes them attractive alternatives to homogeneous basic reagents.
To cite this article
Younes Abrouki, Abdelkader Anouzla, Hayat Loukili, Rabiaâ Lotfi, Ahmed Rayadh, Abdellah Bahlaoui, Saı̈d Sebti, Driss Zakarya, Mohamed Zahouily, Process Optimization for Synthesis of Anti-Tuberculosis Drug Catalyzed by Fluor apatite Supported Potassium Fluoride, American Journal of Theoretical and Applied Statistics. Vol. 2, No. 3, 2013, pp. 81-86. doi: 10.11648/j.ajtas.20130203.16
References
[1]
J. Kozic, E. Novotná, M. Volková, J. Stolaríková, F. Trejtnar, and J. Vinsová, Synthesis and in vitro antimycobacterial activity of 2-methoxybenzanilides and their thioxo analogues, Euro. J. Med. Chem., 56, (2012), pp. 387-395.
[2]
WHO report, Global Tuberculosis Control (2011).http://www.who.int/tb/publications/global report/2011/gtbr11 full.pdf.
[3]
S.T. Cole, G. Riccardi, New tuberculosis drugs on the horizon, Curr. Opin. Microbiol. 14 (2011), pp. 570-576.
[4]
M. Chlupáčová, P. Kubanová, V. Opletalová, V. Buchta, The Importance of the Enone-moiety for Antimycobacterial and Antifungal Properties of Chalcones, Published in: Proceedings of the 3rd International Symposium on Natural Drugs, Naples, 2-4 October 2003. Borelli, F., Capasso, F., Milic, N., Russo, A. (Eds.). Universita degli Studi di Napoli Federico II, Naples - Indena, Milano 2003, pp. 133-135.
[5]
Y. Abrouki, M. Zahouily, A. Rayadh, B. Bahlaouan, S. Sebti, A natural phosphate and doped-catalyzed Michael addition of mercaptans to α,β-unsaturated carbonyl compounds, Tet. Lett., 43, (2002), pp. 8951-8953.
[6]
M. Ceylan, M. B. Gürdere, H. Gezegen, Y. Budak, Potassium-tertiary butoxide-assisted Addition of thioglycolic acid to chalcone derivatives under solvent-free conditions, Synt. Commun., 40 (2010), pp. 2598-2606.
[7]
J. T. Li, Y. Cui, G. F. Chen, Z. L. Cheng, T. S. Li, Michael Addition Catalyzed by Potassium Hydroxide Under Ultrasound, Synthetic Comm., 33, (2003), pp. 353-359.
[8]
H. Hiemstra, H. Wynberg, Addition of aromatic thiols to conjugated cycloalkenones, catalyzed by chiral β-hydroxy amines: A mechanistic study of homogeneous catalytic asymmetric synthesis, J. Am. Chem. Soc., 103 (1981), pp. 417-430.
[9]
T. C. Wabnitz, J. B. Spencer, A general Brønsted Acid-Catalyzed Hetero-Michael Addition of Nitrogen, Oxygen, and Sulfur Nucleophiles, Org. Lett., 12, (2003), pp. 2141-2144.
[10]
Y. Riadi, R. Mamouni, Y. Abrouki, M. El Haddad, N. Saffaj, S. El Antri, S. Routier, G. Guillaumet, S. Lazar, Animal Bone Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition, Tet. Lett., 51, (2010), pp. 6715-6717.
[11]
M. Zahouily, Y. Abrouki, A. Rayadh, S. Sebti, H. Dhimane, and M. David, Fluorapatite: efficient catalyst for the Michael addition, Tet. Lett. 44, (2003), pp. 2463-2465.
[12]
Smahi, A. Solhy, H. El Badaoui, A. Amoukal, A. Tikad, M. Maizi, and S. Sebti, Potassium fluoride doped fluorapatite and hydroxyapatite as new catalysts in organic synthesis Appl. Catal. A. Gen., 250, (2003), pp. 151-159.
[13]
Anouzla, Y. Abrouki, S. Souabi, M. Safi, H. Rhbal, Colour and COD removal of disperse Dye solution by a novel Coagulant: Application of statistical Design for the optimization and Regression analysis, J. Hazard. Mater., 166 (2009), pp. 1302-1306.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186