Survival Analysis of HIV/AIDS Patients Under ART Follow up in Attat Referral Hospital
Science Journal of Applied Mathematics and Statistics
Volume 8, Issue 3, June 2020, Pages: 42-46
Received: Jun. 27, 2020; Accepted: Jul. 24, 2020; Published: Aug. 10, 2020
Views 143      Downloads 64
Authors
Ayele Gebeyehu Chernet, Department of Statistics, College of Natural and Computational Sciences, Wolkite University, Wolkite, Ethiopia
Mohammed Derese Biru, Department of Statistics, College of Natural and Computational Sciences, Wolkite University, Wolkite, Ethiopia
Article Tools
Follow on us
Abstract
Background: The non-curable HIV/AIDS epidemic has become a serious health and development problem especially for developing country like Ethiopia despite using ART treatment. The antiretroviral treatment (ART) scale-up service has been a recent development in Ethiopia, but its impact on mortality has not been well investigated. This study aimed to analyze the survival time of HIV-positive patients under antiretroviral therapy (ART) and identifies associated risk factors in Attat Referral Hospital. Methods: A retrospective study was conducted to examine the survival of HIV/AIDS patients under ART at Attat Referral Hospitals. Total of 408 HIV/AIDS patients in ART from April 30, 2010 up to March 30, 2017 were included in the study. Cox proportional hazard model was employed to assess the survival of HIV/AIDS patients and the associated factors. Results: A total of 408 patients were followed for a survival mean time of 46 months. In the followed-up period, 121 (29.7%) patients dead and 287 (70.3%) patients were censored. Based on functional status of patients, higher mortality was significantly associated with bedridden (HR: 3.934) and Ambulatory (HR: 1.790). According to WHO stages the patients under ART follow up with stage- IV (HR: 7.277), stage-III (HR: 4.536) and stage-II (HR: 2.213) were high risk of dying than patients in stages-I and male patients are at high risk of death than females. Conclusions: This study found that the survival time of the HIV patient under ART follow-ups in Attat Referral Hospital of Guraghe zone was significantly associated with factors: functional status, Weight, Original Regimen, CD4 count and WHO stage.
Keywords
Survival, Cox Proportional Hazard Model, Antiretroviral Therapy
To cite this article
Ayele Gebeyehu Chernet, Mohammed Derese Biru, Survival Analysis of HIV/AIDS Patients Under ART Follow up in Attat Referral Hospital, Science Journal of Applied Mathematics and Statistics. Vol. 8, No. 3, 2020, pp. 42-46. doi: 10.11648/j.sjams.20200803.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Global HIV & AIDS statistics, 2020 fact sheet United Nations Political Declaration on HIV and AIDS. Geneva: UNAIDS, 2020.
[2]
World health organization. HIV drug resistance report. WHO, 2017.
[3]
Ethiopia Country/Regional Operational Plan (COP/ROP). Strategic Direction Summary. April 21, 2017.
[4]
Cox, D. R. Regression Models and Life Tables, Journal of Royal Statistical Society. 1st ed. Hoboken, J Wiley, 1972.
[5]
Cox, D. R. and Snell, E. J. the Analysis of Binary Data. 2nd ed. Hoboken, J Wiley, 1989.
[6]
Rania H, Asma A, Haidar M, Malaz E, Khalid K. Survival and Mortality Analysis for HIV Patients in Khartoum State. Sudan 2017. World Journal of Public Health. Vol. 3, No. 4, 2018; 118-124. doi: 10.11648/j.wjph.20180304.13.
[7]
Sieleunou I, Souleymanou M, Schonenberger AM, Menten J, Boelaert M. Determinants of survival in AIDS patients on antiretroviral therapy in a rural center in the Far-North Province, Cameroon. Trop Med Int Heal. 2009.
[8]
Bhatta L, Klouman E, Deuba K, Shrestha R, Karki DK, Ekstrom AM, et al. Survival on antiretroviral treatment among adult HIV-infected patients in Nepal: a retrospective cohort study in far-western Region, 2006–2011. BMC Infect Dis. 2013; 13 (1): 604.
[9]
Stringer JSA, Zulu I, Levy J, Stringer EM, Mwango A, Chi BH, et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: Feasibility and early outcomes. J Am Med Assoc. 2006.
[10]
Biadgilign S, Reda A, Digaffe T. Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: a retrospective cohort study. AIDS Res Ther. 2012 May 18; 9 (1): 15.
[11]
Alemu AW, Sebastian MS. Determinants of survival in adult HIV patients on antiretroviral therapy in Oromiyaa, Ethiopia. Glob Health Action. 2010.
[12]
Nurilign A, Kassahun A, Tadese A, Amanuel A, Survival status of HIV positive adults on antiretroviral treatment in Debre Markos Referral Hospital, Northwest Ethiopia: retrospective cohort study. panafrican-med journal. 2017.
[13]
Amuron B, Levin J, Birunghi J, Namara G, Coutinho A, Grosskurth H, et al. Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: A prospective cohort study. AIDS Res Ther. 2011.
[14]
Nahom Tesfaluul Negassi, et al Survival Pattern and Its Determinants among Adult HIV-Infected Patients after Initiation of HAART in Dilla Hospital Ethiopia: Department of Laboratory Medicine, 2016.
[15]
Tigiste A, Eshetu W. Survival analysis of patients under Chronic HIV-Care and Antiretroviral Treatment at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. Ethiop J Health Dev 2012; 26 (1): 22-29.
[16]
Tsehaineh B. Assessment of factors associated with high risk of mortality of hiv patients treated with highly active antiretroviral therapy in Jimma zone, south western Ethiopia: application of survival analysis methods (Thesis). 2010. Addis Ababa University. Addis Ababa, Ethiopia.
[17]
Kebebew K. Determining factors that affect the survival rate of HIV-infected patients on art: the case of Armed Forces General Teaching Hospital, Addis Ababa, Ethiopia (Thesis). June, 2011. Addis Ababa University. Addis Ababa, Ethiopia.
[18]
Bedru A, Worku A. Assessment of predictors of survival in patients living with HIV/AIDS after the advent of highly active antiretroviral therapy in Addis Ababa Ethiopia (Thesis). June 2009. Addis Ababa University. Addis Ababa, Ethiopia.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186