Neo-Revascularization as the Potential Treatment for Patient Suffering from Pulmonary Arterial Hypertension (Myth or Reality)
Clinical Medicine Research
Volume 2, Issue 3, May 2013, Pages: 32-36
Received: Apr. 28, 2013;
Published: May 30, 2013
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Aris Lacis, Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia
Inguna Lubaua, Riga Stradins University, Riga, Latvia
Valts Ozolins, Clinic of Pediatric Cardiology and Cardiac Surgery, University Children Hospital, Riga, Latvia
Eriks Jekabsons, Pauls Stradins Clinical University Hospital, Riga, Latvia
Andis Lacis, Riga Stradins University, Riga, Latvia
Mara Ratniece, Pauls Stradins Clinical University Hospital, Riga, Latvia
Andrejs Erglis, Latvian Institute of Cardiology, Riga, Latvia
Pulmonary arterial hypertension (APAH, IPAH) is a devastating, progressive disease with increasingly debilitating symptoms [1,2].Intrapulmonary delivery of autologous stem cells could be beneficial for pathogenetic treatment for patients with severe pulmonary arterial hypertension.Two patients with severe pulmonary artery hypertension received intrapulmonary autologous mesenchymal (mononuclear) stem cell transplantation and stem cell transplantation in pulmonary arteries. Patients were examined by scintigraphy of lungs during the periods 12, 14 and 27 months after stem cell transplantation. We find out that perfusion in all lung segments were improved after 14 and 27 months.
Neo-Revascularization as the Potential Treatment for Patient Suffering from Pulmonary Arterial Hypertension (Myth or Reality), Clinical Medicine Research.
Vol. 2, No. 3,
2013, pp. 32-36.
Rubin L. Primary pulmonary hypertension. N.Engl. J. Med., 1997; 336: 111-17.
Galie N., Rubin L., eds. Pulmonary arterial Hypertension. Epidemiology, pathology, assessment and therapy. J.Am.Coll.Cardiol., 2004; 43: 81-90.
Lammers A.F., Hislop A.A., Flynn Y. et al. Epoprostenol treatment in children with severe pulmonary hypertension. Heart, 2007; 93: 739-43.
Maiya S., Hislop A.A, Flynn Y., et al. Response to bosentan in children with pulmonary hypertension. Heart, 2006; 92:664-70.
Haworth S., Flynn Y., Hislop A.A. Survival and quality of life in children with severe pulmonary hypertension. Heart, 2006;92: (Suppl. II): A14.
Hislop A.A., Flynn Y., Haworth S.G. Summary of the experiences of the UK pulmonary hypertension service for children 2001 – 2005. Proceedings of the American Thoracic Society, 2006; 3: A57.
Suri C., Jones P., F., Patan S., et al. Requisite role of angiothensin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell, 1996; 87: 1171-80 (Pub.Med, 8980224).
Assmus B., Sch?chinger V., Teupe C., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation, 2002; 106: 3009-17 (Pub. Med.: 12473544).
Britten M.B., Abdolmeali N.D., Assmus B. et al. Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI) mechanistic insights from serial contrast – enhanced magnetic resonance imaging. Circulation, 2003; 108 -: 2012 – 8 (Pub. Med. 14557356).
Sch?chinger V., Assmus B., Britten M.B., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction – final one-year results of the TOPCARE-AMI trial. J.Am.Coll.Cardiol., 2004;44:1690-9
Yifn Zhou, Suna Wand Kerth A. Horvath. Direct injection of autologous mesenchymal stromal cells improves myocardial function. Biochem. Biophs, Rec. Sommun., 2009; 18: 390 (3) 902-907.
Strauer B.E. Brehm M., Zeus T et al. Regeneration of human infracted heart muscle by intracoronary mononuclear bone marrow cell transplantation in humans. Circulation, 2002; 106: 1913-18.
Perin E.C. Dahmann H.F.R. Borojevic R. et al. Transendocardial autologous bone marrow cell transplantation for severe chronic ischemic heart failure. Circulation, 2003; 107: 2294–302.
Fuchs S., Satler L.F. Koronovski R. et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease – a feasibility study. J. Am. Coll. Cardiol. 2003; 41:1721-4.
Lācis A., rglis A. Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy. Cardiology in the Young, 2011; 21: 110-112.
Christina L O'Neill , Michelle T O'Doherty , Sarah EJ Wilson , Amer A Rana , Claire E Hirst , Alan W Stitt and Reinhold J Medina. Therapeutic revascularisation of ischemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells. Stem Cell Research & Therapy 2012, 3:31.
Clabby ML., Canter CE., Moller JH., Bridges ND., Hemodynamic data and survival in children with pulmonary hypertension. J. Am. Coll. Cardiol. 1997; 30: 554-560.
Zhu JH., Wang XX., Zhang FR., Shang YP et al. Safety and efficacy of autologous endothelial progenitor cells transplantation in children with idiopathic pulmonary arterial hypertension: Open-Label pilot study. Pediatr. Transplantation 2008; 12: 650-655.
T. Kinnaird, E. Stabile, M.S. Burnett, C.W. Lee, S. Barr, S. Fuchs, S.E. Epstein. Marrow-Derived Stromal Cells Express Genes Encoding a Broad Spectrum of Arteriogenic Cytokines and Promote In Vitro and In Vivo Arteriogenesis Through Paracrine Mechanisms. Circulation Research. 2004; 94: 678-685.
T. Kinnaird, MBBCh; E. Stabile, MD; M.S. Burnett, PhD; M. Shou, MD; C.W. Lee, MD; S. Barr, MBBCh; S. Fuchs, MD; S.E. Epstein, MDLocal Delivery of Marrow-Derived Stromal Cells Augments Collateral Perfusion Through Paracrine Mechanisms. Circulation. 2004; 109: 1543-1549.
Gnecehi M, Mirotsu M, Dzun V.J. Stem cell therapy for heart repair. The paracrine paradigm in "Heart regeneration". Max Planck Institute for heart and lung research, Germany. World scientific Publishing, Co. Ptc. Ltd. Copyright@2012. pp 219-245
Takahashi M, Nakamura T, Toba T, Kajiwara N, Kato H, Shimizu Y. Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs. Tissue Eng. 2004 May-Jun; 10 (5-6): 771-9.