Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience

Sacit Nuri Gorgel; Osman Kose; Ozan Horsanalı; Evren Sahin; Ugur Balci; Kutan Ozer; Cengiz Girgin

doi:doi:10.11648/j.cmr.20140306.19

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Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience

Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, Kutan Ozer, Cengiz Girgin

Published in Clinical Medicine Research (Volume 3, Issue 6)

Received: 11 December 2014 Accepted: 24 December 2014 Published: 31 December 2014

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Abstract

Objectives: To investigate the relation between age and tumor characteristics and to evaluate oncologic results after radical cystectomy in elderly patients. Materials and Methods: We reviewed 501 patients retrospectively who underwent radical cystectomy because of bladder cancer. Patients were divided into two groups; greater than or equal to 70 (group 1) and less than 70-years-old (group 2). We compared tumor pathological characteristics and oncologic results in both groups. American Society of Anesthesiologists (ASA) score is less than three and there was no risk for major surgery for all patients. None of the patients did not receive neoadjuvant radiotherapy and/or chemotherapy. Results: There were 87 (17.4%) patients in group 1 and 414 (82.6%) patients in group 2. The mean age was 73.3±3.01 (70-85) in group 1, and 58.3±7.47 (34-69) in group 2. There were no significantly difference between gender (0.135), pathological T stage (p=0.483), lymph node involvement (p=0.462), grade (p=0.522), type of diversion (p=0.193), histological type (p=0.656) in both groups. Perioperative mortality were 3.9% in group 1 and 3.4% in group 2 (p=0.218). Perioperative complication rates were 16.6 % in group 1 and 17.4% in group 2 (p=0.469). Five years disease specific survival (DSS) rates were 61% in group 1 and 53% in group 2 (p=0.936). The mean DSS periods were 72.91 ± 5.35 months in group 1 and 76.25±7.45 months in group 2. Five years overall survival rates were 43.9% in group 1, 45.9% in group 2 (p=0.476). Mean overall survival periods were 54.02±8.47 in group 1 and 69.25±4.97 in group 2. In cox regression analyse; tumor stage (p=0.012) and lymph node involvement (p<0.001) were significant factors affected the survival in both groups. Conclusions: We found similar oncological results in patients who underwent radical cystectomy because of bladder cancer between young and elderly patients. We believe that age is not a contraindication factor for radical cystectomy operation. In addition preoperative performance statue of patients is important in terms of perioperative complications and mortality.

Published in	Clinical Medicine Research (Volume 3, Issue 6)
DOI	10.11648/j.cmr.20140306.19
Page(s)	206-210
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Bladder Cancer, Elderly, Radical Cystectomy

References

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[17]	Geriatric Assessment Methods for Clinical Decision making. NIH Consensus Statement Online 1987 Oct Online 19-21 [cited 2013 Feb, 6th];6(13):1-21
[18]	Soulié M, Straub M, Gamé X, Seguin P, De Petriconi R, Plante P, et al. A multicenter study of the morbidity of radical cystectomy in select elderly patients with bladder cancer. J Urol. 2002; 167(3): 1325–1328.
[19]	Clark PE, Stein JP, Groshen SG, Cai J, Miranda G, Lieskovsky G, et al. Radical cystectomy in the elderly: comparison of clincal outcomes between younger and older patients. Cancer. 2005; 104(1): 36–43.
[20]	Nielsen ME, Shariat SF, Karakiewicz PI, Lotan Y, Rogers CG, Amiel GE, et al. Advanced age is associated with poorer bladder cancer-specific survival in patients treated with radical cystectomy. Eur Urol. 2007; 51(3): 699–706.
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APA Style

Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. (2014). Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clinical Medicine Research, 3(6), 206-210. https://doi.org/10.11648/j.cmr.20140306.19

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ACS Style

Sacit Nuri Gorgel; Osman Kose; Ozan Horsanalı; Evren Sahin; Ugur Balci, et al. Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clin. Med. Res. 2014, 3(6), 206-210. doi: 10.11648/j.cmr.20140306.19

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AMA Style

Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clin Med Res. 2014;3(6):206-210. doi: 10.11648/j.cmr.20140306.19

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@article{10.11648/j.cmr.20140306.19,
  author = {Sacit Nuri Gorgel and Osman Kose and Ozan Horsanalı and Evren Sahin and Ugur Balci and Kutan Ozer and Cengiz Girgin},
  title = {Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {6},
  pages = {206-210},
  doi = {10.11648/j.cmr.20140306.19},
  url = {https://doi.org/10.11648/j.cmr.20140306.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140306.19},
  abstract = {Objectives: To investigate the relation between age and tumor characteristics and to evaluate oncologic results after radical cystectomy in elderly patients. Materials and Methods: We reviewed 501 patients retrospectively who underwent radical cystectomy because of bladder cancer. Patients were divided into two groups; greater than or equal to 70 (group 1) and less than 70-years-old (group 2). We compared tumor pathological characteristics and oncologic results in both groups. American Society of Anesthesiologists (ASA) score is less than three and there was no risk for major surgery for all patients. None of the patients did not receive neoadjuvant radiotherapy and/or chemotherapy. Results: There were 87 (17.4%) patients in group 1 and 414 (82.6%) patients in group 2. The mean age was 73.3±3.01 (70-85) in group 1, and 58.3±7.47 (34-69) in group 2. There were no significantly difference between gender (0.135), pathological T stage (p=0.483), lymph node involvement (p=0.462), grade (p=0.522), type of diversion (p=0.193), histological type (p=0.656) in both groups. Perioperative mortality were 3.9% in group 1 and 3.4% in group 2 (p=0.218). Perioperative complication rates were 16.6 % in group 1 and 17.4% in group 2 (p=0.469). Five years disease specific survival (DSS) rates were 61% in group 1 and 53% in group 2 (p=0.936). The mean DSS periods were 72.91 ± 5.35 months in group 1 and 76.25±7.45 months in group 2. Five years overall survival rates were 43.9% in group 1, 45.9% in group 2 (p=0.476). Mean overall survival periods were 54.02±8.47 in group 1 and 69.25±4.97 in group 2. In cox regression analyse; tumor stage (p=0.012) and lymph node involvement (p<0.001) were significant factors affected the survival in both groups. Conclusions: We found similar oncological results in patients who underwent radical cystectomy because of bladder cancer between young and elderly patients. We believe that age is not a contraindication factor for radical cystectomy operation. In addition preoperative performance statue of patients is important in terms of perioperative complications and mortality.},
 year = {2014}
}

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TY  - JOUR
T1  - Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience
AU  - Sacit Nuri Gorgel
AU  - Osman Kose
AU  - Ozan Horsanalı
AU  - Evren Sahin
AU  - Ugur Balci
AU  - Kutan Ozer
AU  - Cengiz Girgin
Y1  - 2014/12/31
PY  - 2014
N1  - https://doi.org/10.11648/j.cmr.20140306.19
DO  - 10.11648/j.cmr.20140306.19
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 206
EP  - 210
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20140306.19
AB  - Objectives: To investigate the relation between age and tumor characteristics and to evaluate oncologic results after radical cystectomy in elderly patients. Materials and Methods: We reviewed 501 patients retrospectively who underwent radical cystectomy because of bladder cancer. Patients were divided into two groups; greater than or equal to 70 (group 1) and less than 70-years-old (group 2). We compared tumor pathological characteristics and oncologic results in both groups. American Society of Anesthesiologists (ASA) score is less than three and there was no risk for major surgery for all patients. None of the patients did not receive neoadjuvant radiotherapy and/or chemotherapy. Results: There were 87 (17.4%) patients in group 1 and 414 (82.6%) patients in group 2. The mean age was 73.3±3.01 (70-85) in group 1, and 58.3±7.47 (34-69) in group 2. There were no significantly difference between gender (0.135), pathological T stage (p=0.483), lymph node involvement (p=0.462), grade (p=0.522), type of diversion (p=0.193), histological type (p=0.656) in both groups. Perioperative mortality were 3.9% in group 1 and 3.4% in group 2 (p=0.218). Perioperative complication rates were 16.6 % in group 1 and 17.4% in group 2 (p=0.469). Five years disease specific survival (DSS) rates were 61% in group 1 and 53% in group 2 (p=0.936). The mean DSS periods were 72.91 ± 5.35 months in group 1 and 76.25±7.45 months in group 2. Five years overall survival rates were 43.9% in group 1, 45.9% in group 2 (p=0.476). Mean overall survival periods were 54.02±8.47 in group 1 and 69.25±4.97 in group 2. In cox regression analyse; tumor stage (p=0.012) and lymph node involvement (p<0.001) were significant factors affected the survival in both groups. Conclusions: We found similar oncological results in patients who underwent radical cystectomy because of bladder cancer between young and elderly patients. We believe that age is not a contraindication factor for radical cystectomy operation. In addition preoperative performance statue of patients is important in terms of perioperative complications and mortality.
VL  - 3
IS  - 6
ER  -

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Author Information

Sacit Nuri Gorgel

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey
Osman Kose

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey
Ozan Horsanalı
Evren Sahin

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey
Ugur Balci

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey
Kutan Ozer

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey
Cengiz Girgin

Izmir Katip Celebi University, Ataturk Training and Reseacrh Hospital, Department of Urology, Izmir, Turkey

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Plain Text BibTeX RIS

APA Style

Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. (2014). Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clinical Medicine Research, 3(6), 206-210. https://doi.org/10.11648/j.cmr.20140306.19

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ACS Style

Sacit Nuri Gorgel; Osman Kose; Ozan Horsanalı; Evren Sahin; Ugur Balci, et al. Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clin. Med. Res. 2014, 3(6), 206-210. doi: 10.11648/j.cmr.20140306.19

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AMA Style

Sacit Nuri Gorgel, Osman Kose, Ozan Horsanalı, Evren Sahin, Ugur Balci, et al. Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience. Clin Med Res. 2014;3(6):206-210. doi: 10.11648/j.cmr.20140306.19

Copy | Download

@article{10.11648/j.cmr.20140306.19,
  author = {Sacit Nuri Gorgel and Osman Kose and Ozan Horsanalı and Evren Sahin and Ugur Balci and Kutan Ozer and Cengiz Girgin},
  title = {Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {6},
  pages = {206-210},
  doi = {10.11648/j.cmr.20140306.19},
  url = {https://doi.org/10.11648/j.cmr.20140306.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140306.19},
  abstract = {Objectives: To investigate the relation between age and tumor characteristics and to evaluate oncologic results after radical cystectomy in elderly patients. Materials and Methods: We reviewed 501 patients retrospectively who underwent radical cystectomy because of bladder cancer. Patients were divided into two groups; greater than or equal to 70 (group 1) and less than 70-years-old (group 2). We compared tumor pathological characteristics and oncologic results in both groups. American Society of Anesthesiologists (ASA) score is less than three and there was no risk for major surgery for all patients. None of the patients did not receive neoadjuvant radiotherapy and/or chemotherapy. Results: There were 87 (17.4%) patients in group 1 and 414 (82.6%) patients in group 2. The mean age was 73.3±3.01 (70-85) in group 1, and 58.3±7.47 (34-69) in group 2. There were no significantly difference between gender (0.135), pathological T stage (p=0.483), lymph node involvement (p=0.462), grade (p=0.522), type of diversion (p=0.193), histological type (p=0.656) in both groups. Perioperative mortality were 3.9% in group 1 and 3.4% in group 2 (p=0.218). Perioperative complication rates were 16.6 % in group 1 and 17.4% in group 2 (p=0.469). Five years disease specific survival (DSS) rates were 61% in group 1 and 53% in group 2 (p=0.936). The mean DSS periods were 72.91 ± 5.35 months in group 1 and 76.25±7.45 months in group 2. Five years overall survival rates were 43.9% in group 1, 45.9% in group 2 (p=0.476). Mean overall survival periods were 54.02±8.47 in group 1 and 69.25±4.97 in group 2. In cox regression analyse; tumor stage (p=0.012) and lymph node involvement (p<0.001) were significant factors affected the survival in both groups. Conclusions: We found similar oncological results in patients who underwent radical cystectomy because of bladder cancer between young and elderly patients. We believe that age is not a contraindication factor for radical cystectomy operation. In addition preoperative performance statue of patients is important in terms of perioperative complications and mortality.},
 year = {2014}
}

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TY  - JOUR
T1  - Radical Cystectomy in Elderly Patients, Single Center, 25 Years Experience
AU  - Sacit Nuri Gorgel
AU  - Osman Kose
AU  - Ozan Horsanalı
AU  - Evren Sahin
AU  - Ugur Balci
AU  - Kutan Ozer
AU  - Cengiz Girgin
Y1  - 2014/12/31
PY  - 2014
N1  - https://doi.org/10.11648/j.cmr.20140306.19
DO  - 10.11648/j.cmr.20140306.19
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 206
EP  - 210
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20140306.19
AB  - Objectives: To investigate the relation between age and tumor characteristics and to evaluate oncologic results after radical cystectomy in elderly patients. Materials and Methods: We reviewed 501 patients retrospectively who underwent radical cystectomy because of bladder cancer. Patients were divided into two groups; greater than or equal to 70 (group 1) and less than 70-years-old (group 2). We compared tumor pathological characteristics and oncologic results in both groups. American Society of Anesthesiologists (ASA) score is less than three and there was no risk for major surgery for all patients. None of the patients did not receive neoadjuvant radiotherapy and/or chemotherapy. Results: There were 87 (17.4%) patients in group 1 and 414 (82.6%) patients in group 2. The mean age was 73.3±3.01 (70-85) in group 1, and 58.3±7.47 (34-69) in group 2. There were no significantly difference between gender (0.135), pathological T stage (p=0.483), lymph node involvement (p=0.462), grade (p=0.522), type of diversion (p=0.193), histological type (p=0.656) in both groups. Perioperative mortality were 3.9% in group 1 and 3.4% in group 2 (p=0.218). Perioperative complication rates were 16.6 % in group 1 and 17.4% in group 2 (p=0.469). Five years disease specific survival (DSS) rates were 61% in group 1 and 53% in group 2 (p=0.936). The mean DSS periods were 72.91 ± 5.35 months in group 1 and 76.25±7.45 months in group 2. Five years overall survival rates were 43.9% in group 1, 45.9% in group 2 (p=0.476). Mean overall survival periods were 54.02±8.47 in group 1 and 69.25±4.97 in group 2. In cox regression analyse; tumor stage (p=0.012) and lymph node involvement (p<0.001) were significant factors affected the survival in both groups. Conclusions: We found similar oncological results in patients who underwent radical cystectomy because of bladder cancer between young and elderly patients. We believe that age is not a contraindication factor for radical cystectomy operation. In addition preoperative performance statue of patients is important in terms of perioperative complications and mortality.
VL  - 3
IS  - 6
ER  -

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