Clinical Medicine Research
Volume 4, Issue 3, May 2015, Pages: 87-91
Received: Apr. 22, 2015;
Accepted: May 6, 2015;
Published: May 19, 2015
Views 4417 Downloads 161
Hijrah Harmansyah, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Ema Alasiry, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Dasril Daud, Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC <1800/mm3, ANC 1800-5399/mm3 and ANC >5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p<0.001); OR 8.143; IK 95% 2.440-27.173. Cut off point of 10.710-10890/mm3 was found from ROC analyses in ANC >5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.
Absolute Neutrophil Count as Predictor of Early Onset Sepsis, Clinical Medicine Research.
Vol. 4, No. 3,
2015, pp. 87-91.
Sudarianto., Mursalim., Nur, M., Syahrir., Nurmiyati., Haruna, I., et al. Health profile of South Sulawesi 2008. Public Health Office of South Sulawesi. 2009; (1)
Alamsyah, Effek. Epidemiological analysis of neonatal maternal health efforts in Indonesia in achieving the target of millenium development goals (mdgs) 2015. Buletin Perinasia. 2010; (1)
Burgner, D., Strunk, T. Genetic Susceptibility to Neonatal Infection. Department of Neonatal Paediatrics. Australia. 2006; 19 (3): 259-63.
Schmutz, N., Henry, E., Jopling, J., Christensen, D. Expected ranges for blood neutrophil concentrations of neonates: The Manroe and Mouzinho charts revisited. J Perinatol. 2008; 28 (4): 275-81.
Bhandari, V., Wang, C., Rinder, C., Rinder, H. Hematologic profile of sepsis in neonates: neutrophil cd64 as a diagnostic marker. Pediatrics. 2008; 121: 129.
Bellig, L., Ohning, B. Neonatal sepsis. http://emedicine.medscape.com/article/978352-overview. 2014
Anwer, K., Mustafa, S. Rapid identification of neonatal sepsis. Journal of Pakistan Medical Association. 2000.
Health Ministry of Indonesia. Management of Sepsis Neonatorum. 2007.
Dzwonek AB., Neth OW., Thiebaut R., Gulczynska E., Chilton M., Hellwig T. The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatric Research. 2008; 63: 680-85.
Frakking, F.N.J., Brouwer, N., Eijkelenburg, N.K.A. Van, Merkus, M.P., Kuijpers, T.W., et al. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. British society for immunology, Clinical and Experimental Immunology. 2007; 150: 255-62.
Schlapbach L.J., Mattmann M., Thiel S., Boillat C., Otth M., Nelle M., et al. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. 2010; 1058-4838/2010/5102-0006.
Mohamed, W. A. Wahab., Saeed, M. A. Mannose-binding lectin serum levels in neonatal sepsis and septic shock. Journal of Maternal-Fetal and Neonatal Medicine. 2012; 25 (4): 411–414.